Results 41 to 50 of about 1,239,207 (305)

Variations on fibrinogen-erythrocyte interactions during cell aging. [PDF]

PLoS ONE, 2011
Erythrocyte hyperaggregation, a cardiovascular risk factor, is considered to be caused by an increase in plasma adhesion proteins, particularly fibrinogen.
Filomena A Carvalho, Sofia de Oliveira, Teresa Freitas, Sónia Gonçalves, Nuno C Santos   +4 more
doaj   +1 more source

Invasion pathways and malaria severity in Kenyan Plasmodium falciparum clinical isolates. [PDF]

, 2007
The invasion of erythrocytes by Plasmodium falciparum occurs through multiple pathways that can be studied in vitro by examining the invasion of erythrocytes treated with enzymes such as neuraminidase, trypsin, and chymotrypsin.
Kai, Oscar, Conway, David J, Deans, Anne-Marie, Marsh, K, Conway, DJ, Conway, David J., Kai, O, Rowe, J. Alexandra, Rowe, J Alexandra; id_orcid, Marsh, Kevin, Deans, AM, Rowe, J Alexandra, Nery, S, Nery, Susana, Rowe, JA   +14 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Multiscale simulation of erythrocyte membranes [PDF]

Physical Review E, 2010
To quantitatively predict the mechanical response and mechanically induced remodeling of red blood cells, we developed a multiscale method to correlate distributions of internal stress with overall cell deformation. This method consists of three models at different length scales: in the complete cell level the membrane is modeled as two distinct layers
Zhangli, Peng, Robert J, Asaro, Qiang, Zhu   +2 more
openaire   +2 more sources

Atomic force microscopy of erythrocytes of patients with different severity of pancreatitis

Сибирский научный медицинский журнал, 2023
Aim of the study was to prove the possibility of using red blood cell probe microscopy as a predictor of the development of pancreonecrosis.Material and methods. Atomic force microscopy was performed in 143 people (82 were male and 61 were female).
R. A. Pakhomova, L. V. Kochetova, G. N. Gulikian, A. P. Martseva, V. V. Kozlov   +4 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

The malaria secretome: from algorithms to essential function in blood stage infection [PDF]

, 2008
The malaria agent <i>Plasmodium falciparum</i> is predicted to export a "secretome" of several hundred proteins to remodel the host erythrocyte.
Kooij Taco, John Adams, Harrison Travis, uvik So Bhattacharjee, Andrew P. Waters, Andy Waters, Waters, A.P., Harrison, T., Travis Harrison, Balu, B., van Ooij Christiaan, Haldar Kasturi, Adamson, J., Liolios Konstantinos, Kooij, T.W.A., N Luisa Hiller, Konstantinos Liolios, Souvik Bhattacharjee, Chris J. Janse, Christiaan van Ooij, Haldar, K., Balu Bharath, Hiller N. Luisa, Christiaan van Ooij, N. Luisa Hiller, Janse, C.J., Pamela Tamez, Ramesar, J., Bharath Balu, Kasturi Haldar, Chris Janse, Waters Andy, Janse Chris, Tamez Pamela, van Ooij, C., Hiller, N.L., Chris J Janse, Jai Ramesar, Tamez, P., Bhattacharjee, S., Ramesar Jai, Liolios, K., Taco Kooij, Adams John, Bhattacharjee Souvik, Andrew P Waters   +45 more
core   +1 more source

Tuning of Differential Lipid Order Between Submicrometric Domains and Surrounding Membrane Upon Erythrocyte Reshaping

Cellular Physiology and Biochemistry, 2018
Background/Aims: Transient nanometric cholesterol- and sphingolipid-enriched domains, called rafts, are characterized by higher lipid order as compared to surrounding lipids.
Catherine Leonard, Hélène Pollet, Christiane Vermylen, Nir Gov, Donatienne Tyteca, Marie-Paule Mingeot-Leclercq   +5 more
doaj   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source