Results 111 to 120 of about 63,832 (257)

An immune basis for malaria protection by the sickle cell trait. [PDF]

, 2005
BACKGROUND: Malaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for over half a century. Nevertheless, the mechanism of this resistance remains the subject of considerable debate.
Alexander, ND, Kortok, M, Wambua, S, Kevin Marsh, David J Weatherall, Snow, Robert, Roberts, DJ, Moses Kortok, Wambua, Sammy, Mwangi, TW, Thomas N Williams, Williams, TN, Mwangi, Tabitha W., Mwangi Tabitha W, Snow, Robert W, Weatherall, David J., Weatherall David J, Williams, Thomas N., Marsh Kevin, Snow, RW, Alexander, Neal D, Robert W Snow, Marsh, K, Weatherall, David J, Snow, Robert W., Wambua Sammy, Snow Robert W, Williams Thomas N, Roberts, David J, Weatherall, DJ, David J Roberts, Alexander Neal D, Williams, Thomas N, Tabitha W Mwangi, Mwangi, Tabitha W, Roberts, David J., Kortok Moses, Neal D Alexander, Williams, Thomas, Kortok, Moses, Marsh, Kevin, Alexander, Neal D., Sammy Wambua, Roberts David J   +43 more
core   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Influence of Morus alba Leaves Extract on Human Erythrocytes

Biology
Morus alba L. (MA) is a member of the Moraceae family, known as “white mulberry”. Due to the high levels of bioactive compounds, mulberry plants can be considered a good source of nutrients and antioxidant compounds.
Stefano Putaggio, Annamaria Russo, Giuseppe Tancredi Patanè, Antonella Calderaro, Santa Cirmi, Ivana Verboso, Giuseppina Laganà, Silvana Ficarra, Davide Barreca, Françisco Raymo, Ester Tellone   +10 more
doaj   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Piezo1 Channel Activators Yoda1 and Yoda2 in the Context of Red Blood Cells

Biomolecules
Piezo1 is a mechanosensitive non-selective cation channel. Genetic alterations of the channel result in a hematologic phenotype named Hereditary Xerocytosis.
Min Qiao, Reetta Penttinen, Ariel Coli, Nicoletta Murciano, Felix M. Maurer, Christian Wagner, Maria Giustina Rotordam, Lars Kaestner   +7 more
doaj   +1 more source

Nitrite+erythrocytes inhibited platelet aggregation.

, 2013
(A) ADP induced platelet aggregation in PRP+erythrocytes (20% hematocrit) in the concentration dependent manner. (B) Erythrocytes at 0, 1, 10 and 20% hematocrit did not have effect on ADP-induced platelet aggregation in the absence of nitrite.
Supeenun Unchern (334727), Egarit Noulsri (334730), Dusadee Kittikool (334728), Nathawut Sibmooh (99549), Kovit Pattanapanyasat (258129), Sirada Srihirun (334725), Alan N. Schechter (99551), Thanaporn Sriwantana (334726), Barbora Piknova (99548), Suthat Fucharoen (164423)   +9 more
core   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Comparing Nanomechanical Properties and Membrane Roughness Along the Aging of Human Erythrocytes

Methods and Protocols
Erythrocyte (RBC) aging involves significant structural and nanomechanical alterations crucial to their function. This study aims to bridge the gap between analyses based on statistical morphometric parameters, e.g., membrane roughness, and those based ...
Giovanni Longo, Simone Dinarelli, Federica Collacchi, Marco Girasole   +3 more
doaj   +1 more source

Peculiarities in Changes of Peroxide Haemolysis of Erythrocytes in Patients with Generalized Periodontitis Combined with Iron Deficiency Anemia

, 2015
Introduction. Changes of peroxide resistance of erythrocytes as a reflection of the metabolic displacements, relating to the development of inflammation in the periodontal tissues can serve as an informative test for the assessment of the nature of ...
Slaba O.
core   +1 more source

From Fiber Bundles to Architected Membranes: Triply Periodic Minimal Surface Architectures for Biohybrid Artificial Lungs

Advanced Materials, EarlyView.
Additively manufactured triply periodic minimal surface (TPMS) membranes offer an architecture‐driven alternative to hollow fiber bundles in artificial lungs. Multiphysics simulations and endothelialized prototypes show that the 3D‐printable membrane architecture improves gas exchange, blood flow distribution, and hemocompatibility, enabling ...
Michael Pflaum, Kai P. Barbian, Florian Neuhaus, Gerrit Sitarz, Carolin Nölke, Sebastian V. Jansen, John Linkhorst, Lukas T. Hirschwald, Sebastian Brosch, Christian Certa, Ulrich Steinseifer, Matthias Wessling, Jutta Arens, Arjang Ruhparwar, Bettina Wiegmann   +14 more
wiley   +1 more source