Results 131 to 140 of about 680,017 (354)

Vimentin downregulation is an inherent feature of murine erythropoiesis and occurs independently of lineage [PDF]

, 1990
In mammalian erythropoiesis, the mature cells of the primitive lineage remain nucleated while those of the definitive lineage are anuclear. One of the molecular and structural changes that precedes enucleation in cells of the definitive lineage is the ...
Lazarides, Elias, Sangiorgi, Frank, Woods, Catherine M.   +2 more
core  

Optimization of the Nonclinical Biological Evaluation of Medical Devices Using Toxicologic Pathology Best Practices

Advanced Healthcare Materials, EarlyView.
Nonclinical evaluation of biological responses to implanted medical devices and combination products in animals is required to predict possible outcomes and risks in patients. This paper describes globally accepted pathology “best practices” that 1) effectively address ISO standards and current regulatory guidance for medical device development and 2 ...
Kathleen A. Funk, JoAnn C. L. Schuh, Brad Bolon, Valerie S. Thomas, Jeffrey I. Everitt, Abraham Nyska, Jaime Paulin   +6 more
wiley   +1 more source

Hyposplenism in gastro-intestinal disease [PDF]

, 1994
The hazards of living without a spleen were recognised by the paediatricians in the early 1960’s when they focussed attention on the syndrome of fulminant sepsis, often due to pneumococcal infection, occurring in young children within the first two years
Muller, Andre F., Toghill, P. J.
core   +1 more source

Myeloperoxidase Luminol Reaction – A Novel Faecal Assay for Predicting Colonoscopy Findings in Patients with Ulcerative Colitis: A Pilot Cross‐Sectional Clinical Study

Advanced Healthcare Materials, EarlyView.
Can luminol detect faecal inflammation? This study explores the development and optimisation of a rapid novel assay ‐ Myeloperoxidase Luminol Reaction (MPOLR) for the detection of faecal myeloperoxidase activity. This simple and rapid luminol‐based approach competes with clinically validated faecal biomarkers in predicting endoscopic findings in ...
Viraj Kariyawasam, Taylor Davis, Mark Ghali, David Tejcek, Thomas R O'Neil, Ella Verley, Matthew Griffiths, Miguel Campos, Ingrid Bonney, Andrew C. Bulmer, Yogambha Ramaswamy, Nikola Mitrev, Crispin Corte, Paul K. Witting, Belal Chami   +14 more
wiley   +1 more source

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Two-dimensional iodopeptide mapping demonstrates that erythrocyte Rh D, c, and E polypeptides are structurally homologous but nonidentical [PDF]

, 1988
Dominique Blanchard, C Bloy, Patricia Hermand, JP Cartron, AM Saboori, BL Smith, Peter Agre   +6 more
openalex   +1 more source

Synthetic Hydrogels Incorporating Hydrolytic/Nonhydrolytic Macromer Ratios Exhibit Improved Tunability of In Vivo Degradation and Immune Responses

Advanced Healthcare Materials, EarlyView.
A synthetic 4‐arm maleimide‐terminated poly(ethylene glycol) (PEG‐4MAL) hydrogel system that combines hydrolytic ester‐linked macromer (PEG‐4eMAL) with nondegradable amide‐linked macromer (PEG‐4aMAL) in various stoichiometric ratios to tune the degradability rate. The macromers are crosslinked with dithiothreitol via thiol‐maleimide click reaction. The
Michael D. Hunckler, Sophia Kioulaphides, Karen E. Martin, Angelica L. Torres, Graham F. Barber, Stephen W. Linderman, Rebecca S. Schneider, Andrés J. García   +7 more
wiley   +1 more source

Confirmation of a Structural Abnormity in the Stroma of Erythrocytes from Paroxysmal Nocturnal Hemoglobinuria (PNH) After Hemolysis in Distilled Water [PDF]

, 1956
H Braunsteiner, E Gisinger, F. Pakesch
openalex   +1 more source

A Modular Perfusion Bioreactor Platform for Simulating Bone Regeneration and Fracture Healing: Integrating Mechanical Loading and Dual Perfusion for Advanced In Vitro Models

Advanced Healthcare Materials, EarlyView.
A modular bioreactor platform was developed in order to replicate bone homeostasis and pathology, thereby integrating mechanical loading, dynamic perfusion, and a 3D‐printed microfluidic chamber. With precise control of environmental parameters and dual perfusion for composite tissue models, the system enhances physiological relevance for studying bone
Moritz Pfeiffenberger, Alexandra Damerau, Johannes Plank, Adel Ahmed, Mario Thiele, Jan Saam, Paula Hoff, Timo Gaber, Frank Buttgereit   +8 more
wiley   +1 more source

Current Challenges in Hemostasis and Advances in Particle‐Assisted Styptic Devices

Advanced Healthcare Materials, EarlyView.
Here persistent limitations in hemostatic technologies are highlighted and cutting‐edge biomimetic, microparticle‐assisted, and nanoengineered systems with integrated drug delivery are showcased. Moreover, the article identifies fresh directions toward the next‐generation of multifunctional hemostatic devices with superior efficacy and accessibility ...
Daniele Baiocco, Zhibing Zhang, Neil M. Eisenstein, Nigel Tai, Liam M. Grover   +4 more
wiley   +1 more source