Results 141 to 150 of about 55,366 (304)
The FEBS Journal, EarlyView.Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal +8 more
wiley +1 more source
Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders
The FEBS Journal, EarlyView.Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo +6 more
wiley +1 more source
Bakalářská práce se zabývá vývojem erytrocytů a faktory ovlivňujícími erytropoézu. V úvodu práce jsou stručně popsány vývojové řady erytropoézy a embryonální vývoj erytropoézy.
Lorencová, Jana
core
Congenital disorders of erythropoiesis.
, 1976 Symposium on congenital disorders of erythropoiesis held at the Ciba Foundation, London, 12th-14th March, 1975.
core
A quantitative dissection of the DNA‐binding properties of pathogenic GATA1 mutants
The FEBS Journal, EarlyView.Transcription factor activity is influenced by cell context, accessibility of target sequences, and co‐factor recruitment. Quantitatively characterizing the consequences of individual mutations in the transcription factors or their target sequences remains technically challenging. Zambo et al. use mutant GATA1‐ATP2B4 binding to illustrate an innovation
Kaoru Takasaki
wiley +1 more source
Dialysis and Pregnancy: Optimizing Therapy for Best Maternal and Fetal Outcomes
Hemodialysis International, EarlyView.ABSTRACT Pregnancy in women with end‐stage kidney disease (ESKD) requiring dialysis remains high risk, with significant maternal and fetal complications. While fertility rates are markedly reduced in this population, advances in dialysis care and obstetric management have led to increasing reports of successful pregnancies.
Shreepriya Mangalgi, Silvi Shah
wiley +1 more source
Hemodialysis International, EarlyView.ABSTRACT Objective To conduct a meta‐analysis of clinical randomized controlled studies related to vitamin D supplements for the treatment of anemia in patients with chronic kidney disease (CKD), to evaluate the clinical efficacy of vitamin D supplements for CKD patients complicated with anemia.
Xiaodong Wanyan, Jiayun Xu
wiley +1 more source
, 2012 In erythropoiesis growth factors like stem cell factor (SCF) and erythropoietin (EPO) react with intrinsically expressed receptors, c-kit and EPO receptor (EPOR) [1] respectively to regulate cell survival, differentiation and proliferation.
Saraf, Pritha.
core
Hemodialysis International, EarlyView.ABSTRACT Background Iron overload in chronic kidney disease contributes to oxidative injury. The role of iron chelators, standard in transfusion‐related overload, remains unclear in chronic kidney disease. Aim To evaluate the efficacy and safety of iron chelators in adults with chronic kidney disease.
Humam Emad Rajha +6 more
wiley +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Aim Hypoxic preconditioning of cells holds promise for regenerative therapies, yet identifying effective and safe methods for clinical application remains challenging. We aimed to determine optimal hypoxia‐mimetic small molecules (SMs) that stabilize hypoxia‐inducible factor‐1α (HIF‐1α) and their dosages for hypoxic preconditioning in stem ...
Hong Wang +9 more
wiley +1 more source