Abstract Background Acute pain transfusion reaction (APTR) is a rare, under‐recognized condition of unknown etiology. It can cause significant distress in recipients, necessitating symptomatic management and, occasionally, hospitalization. Study Design and Methods Here, we present an APTR event in an adult subject with transfusion‐dependent thalassemia
Georgia Tzafa +20 more
wiley +1 more source
Imperfect Maturation of Erythroid Progenitors in Patients with Cirrhosis-Associated Anemia. [PDF]
Lal D +4 more
europepmc +1 more source
Safety and tolerability of amustaline/glutathione pathogen‐reduced red blood cells in neonatal rats
Abstract Background Amustaline (S‐303)/glutathione (GSH) pathogen‐reduced red blood cells (PR‐RBCs) are in development for all adult and pediatric RBC transfusion indications, including neonates and infants. A neonatal rat model evaluated the safety and tolerability of PR‐RBCs during growth and maturation. Study Design and Methods Repeated transfusions
Anne North +3 more
wiley +1 more source
Uncoupling Erythropoiesis from Cardiorenal Effects: SGLT2 Inhibition in Non-Diabetic Heart Failure. [PDF]
Măgureanu DC +5 more
europepmc +1 more source
Rare antigen‐negative red blood cells from pluripotent stem cells for precision transfusion medicine
Abstract Background Blood bank identification of antibodies against high‐prevalence antigens remains a challenge due to the scarcity of antigen‐negative reagent red cells sourced from blood donors. The MAM antigen, encoded by EMP3, is one such antigen associated with red cell alloimmunization and hemolytic disease of the fetus and newborn. Study Design
Naomi Gunawardena +9 more
wiley +1 more source
The Lung-Kidney Axis: A Coordinated Regulation of Oxygen Sensing and Erythropoiesis. [PDF]
Al Rajeh AM.
europepmc +1 more source
A ferritin prediction model to determine individual blood donation frequencies
Abstract Background Ferritin‐guided donation intervals are effective in reducing iron deficiency and low hemoglobin rates. However, many donors still present with low ferritin levels after multiple donations, which results in less donor availability. Model predictions of ferritin levels can help in setting donation frequencies that, proactively, keep ...
Mart Pothast +3 more
wiley +1 more source
Elevated hemoglobin levels associated with severe sleep-disordered breathing in hemodialysis patients not receiving erythropoiesis-stimulating agents: a case series. [PDF]
Matsumoto H, Murai S.
europepmc +1 more source
Histiocytes: Multifaceted Regulators of Health and Disease
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley +1 more source
A cell-nonautonomous heme acquisition pathway enables erythroid hemoglobinization under stress. [PDF]
Belot A +8 more
europepmc +1 more source

