Results 121 to 130 of about 62,107 (294)

TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis

open access: yesAutoimmunity, 2018
Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia.
Stephen L. Rego   +6 more
doaj   +1 more source

The Diagnosis and Prenatal Management of Non‐RHD Alloimmunizations

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Red blood cell (RBC) alloimmunization remains a relevant cause of hemolytic disease of the fetus and newborn (HDFN). Although RhD immunization has significantly decreased since the implementation of systematic prophylaxis, it is still the main cause of alloimmunization in pregnancy.
Mar Bennasar, Antoni Borrell
wiley   +1 more source

Biological Specificities of Fetal Anemia Induced by Parvovirus B19 Infection

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Objective To describe the biological fetal parameters in cases of severe anemia induced by parvovirus B19 (B19V) infection. Method A retrospective single center study was conducted including cases of fetal anemia due to B19V receiving in utero transfusion (IUT) from January 2011 to May 2024.
Anaïs Dugas   +9 more
wiley   +1 more source

HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency

open access: yes, 2018
Key Points Erythroid eIF2αP and ATF4 are essential for iron-restricted erythropoiesis, and HRI-eIF2αP is responsible for microcytic hypochromic anemia.
Alejandra Macias-Garcia   +5 more
core   +1 more source

The association between red blood cell distribution width‐to‐albumin ratio and risk of insomnia: A cross‐sectional analysis of National Health and Nutrition Examination Survey and Chinese clinical data

open access: yesSleep Research, EarlyView.
Abstract Background The red blood cell distribution width‐to‐albumin ratio (RAR) is a novel composite biomarker of inflammation and nutritional status, yet its association with insomnia and underlying mechanisms remain poorly understood. Objective To investigate the association between the RAR and insomnia in two independent cohorts, comprising a ...
Jingying Ma   +7 more
wiley   +1 more source

Expression of alpha-hemoglobin stabilizing protein gene during human erythropoiesis

open access: yes, 2015
alpha-Hemoglobin stabilizing protein (AHSP) is an abundant, erythroid-specific protein that forms a stable complex with free alpha-hemoglobin but not with beta-hemoglobin or hemoglobin A.
Duarte, ASS   +3 more
core   +1 more source

Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals

open access: yesIntegrative Zoology, EarlyView.
This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley   +1 more source

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

open access: yesIntegrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong   +5 more
wiley   +1 more source

Regulation of erythropoiesis

open access: yes
Bakalářská práce se zabývá vývojem erytrocytů a faktory ovlivňujícími erytropoézu. V úvodu práce jsou stručně popsány vývojové řady erytropoézy a embryonální vývoj erytropoézy.
Lorencová, Jana
core   +1 more source

Limited Clinical Impact of Androgen Receptor Repeat Length (CAG and GGC) in Klinefelter Syndrome: A Multivariable Analysis

open access: yesAndrology, EarlyView.
ABSTRACT Background Klinefelter syndrome (KS) is characterized by marked phenotypic heterogeneity that might be influenced by genetic modifiers, including androgen receptor (AR) repeat length (CAGn and GGCn). The clinical relevance of these repeat lengths in patients with KS before testosterone replacement therapy (TRT) remains unclear.
Andrea Graziani   +8 more
wiley   +1 more source

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