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Leukemia Research, 1990
The remarkable capacity of the bone marrow to compensate for blood loss and for reduced atmospheric oxygen tension has been found to be mediated by a renal hormone, named erythropoietin. It is produced by peritubular interstitial cells in response to renal hypoxia, but molecular engineering has permitted large scale production of an identical ...
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The remarkable capacity of the bone marrow to compensate for blood loss and for reduced atmospheric oxygen tension has been found to be mediated by a renal hormone, named erythropoietin. It is produced by peritubular interstitial cells in response to renal hypoxia, but molecular engineering has permitted large scale production of an identical ...
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Archives of Internal Medicine, 1973
Erythropoietin (Epo), the first growth factor to be discovered, is an endocrine hormone produced by specialized renal cells. The rate of Epo production is determined primarily by the oxygen demands of these renal cells relative to their oxygen supply.
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Erythropoietin (Epo), the first growth factor to be discovered, is an endocrine hormone produced by specialized renal cells. The rate of Epo production is determined primarily by the oxygen demands of these renal cells relative to their oxygen supply.
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Erythropoietin and Erythropoietin Receptor in Colorectal Cancer
International Journal of Surgical Pathology, 2008Erythropoietin via erythropoietin receptor effectively prevents anemia, giving reasons for a clinical use of erythropoietin in patients with colorectal cancers. However, erythropoietin seems to promote survival of the neoplastic cells in hypoxic environment.
Mariusz Koda +5 more
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Blut, 1976
Abstract Epo was purified from the urine of anaemic patients(Miyake et al. 1977), and the amino acid sequence derived from the purified protein {Lai et al. 1986) led to the cloning of the human epo gene {Lin et al. 1985; Jacobs et al. 1985).
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Abstract Epo was purified from the urine of anaemic patients(Miyake et al. 1977), and the amino acid sequence derived from the purified protein {Lai et al. 1986) led to the cloning of the human epo gene {Lin et al. 1985; Jacobs et al. 1985).
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Pediatrics, 1959
ERYTHROPOIETINE is a protein, capable of stimulating erythrocyte production, which is found in the plasma of animals subjected to hypoxia or following the administration of cobalt. Sufficient data have been accumulated in the more common hematologic disorders to draw some tentative conclusions about its etiologic and therapeutic significance in ...
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ERYTHROPOIETINE is a protein, capable of stimulating erythrocyte production, which is found in the plasma of animals subjected to hypoxia or following the administration of cobalt. Sufficient data have been accumulated in the more common hematologic disorders to draw some tentative conclusions about its etiologic and therapeutic significance in ...
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Down with the Erythropoietin. Long Live the Erythropoietin !
Current Drug Targets, 2009In recent years the use of erythropoietin has exploded, and the anaemia of patients with chronic renal failure has been practically resolved with the administration of rHuEpo (recombinant human, Erythropoietin). However, as a result of an intense commercial campaign, strong therapies with this growth hormone, prescribed to achieve surprising sporting ...
BUEMI, Michele +8 more
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1969
Publisher Summary This chapter provides an overview of erythropoietin. Erythropoietin, also referred to as hemopoietin, erythropoietic stimulating factor (ESF) and erythropoietic factor, is a substance capable of stimulating erythropoiesis in the normal animal.
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Publisher Summary This chapter provides an overview of erythropoietin. Erythropoietin, also referred to as hemopoietin, erythropoietic stimulating factor (ESF) and erythropoietic factor, is a substance capable of stimulating erythropoiesis in the normal animal.
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Hematology/Oncology Clinics of North America, 1994
The physiology of maternal and fetal erythropoiesis in pregnancy shows that hematopoiesis, and the stimulation of hematopoiesis, take place separately in the two circulations. Erythropoietin appears the main regulator in both mother and fetus. The human placenta forms a manifest barrier to endogenous and recombinant erythropoietin, thus fulfilling the ...
Albert Huch, Renate Huch
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The physiology of maternal and fetal erythropoiesis in pregnancy shows that hematopoiesis, and the stimulation of hematopoiesis, take place separately in the two circulations. Erythropoietin appears the main regulator in both mother and fetus. The human placenta forms a manifest barrier to endogenous and recombinant erythropoietin, thus fulfilling the ...
Albert Huch, Renate Huch
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Erythropoietin and Erythropoiesis
Annals of Internal Medicine, 1966Excerpt Investigations of the mechanism of regulation of red cell production have received their impetus in recent years from the classical experiments of Reissman (1), which clearly established th...
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