Results 61 to 70 of about 74,697 (278)
Research progress of neurovascular units involved in ischemic stroke
Ibrain, EarlyView.The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang +4 more
wiley +1 more source
Haematologica, 2016 Erythropoietin is essential for the production of mature erythroid cells, promoting both proliferation and survival. Whether erythropoietin and other cytokines can influence lineage commitment of hematopoietic stem and progenitor cells is of significant ...
Daniel Ward +4 more
doaj +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Two hundred fifty‐three adults were enrolled in a cross‐sectional study conducted in Northern Sudan. The RVs of hemoglobin 9.71–16.10 g/dL, red blood cells (RBC) 3.66–5.79 × 106/mm3, hematocrit (HCT) 28.02%–46.75%, mean corpuscular volume (MCV) 64.02–95.65 fL, mean corpuscular hemoglobin (MCH) 21.57–33.80 pg, mean corpuscular hemoglobin concentration ...
Mohamed F. Lutfi +2 more
wiley +1 more source
Anti-Erythropoietin Antibody Associated Pure Red Cell Aplasia Resolved after Liver Transplantation
Case Reports in Transplantation, 2015 Patients undergoing antiviral therapy for chronic hepatitis C often develop anemia secondary to ribavirin and interferon. Recombinant erythropoietin has been used to improve anemia associated with antiviral therapy and to minimize dose reductions, which ...
Annie K. Hung +3 more
doaj +1 more source
Molecular Nutrition &Food Research, EarlyView.(Poly)phenols constitute a source of natural therapeutic molecules capable of targeting angiogenesis in different scenarios. This review summarizes the current evidence of the role of (poly)phenols in modulating angiogenesis. The reader can find a compilation of preclinical and human investigations describing pro‐ and anti‐angiogenic effects of these ...
María Ángeles Ávila‐Gálvez +5 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre +5 more
wiley +1 more source
Tutorial for Modeling Delays in Biological Systems in the NONMEM Software
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Delays in biological systems are a common phenomenon. The models for delays require specialized mathematical and numerical techniques such as transit compartments, delay differential equations (DDEs), and distributed DDEs (DDDEs). Because of mathematical complexity, DDEs and particularly DDDEs are infrequently used for modeling.
Robert J. Bauer, Wojciech Krzyzanski
wiley +1 more source
Cryomicroneedle Arrays for Biotherapeutics Delivery
Small Science, EarlyView.CryoMNs for biotherapeutic delivery to treat various diseases. CryoMNs: cryomicroneedles. Biotherapy offers a promising approach for treating a variety of diseases. However, the lack of advanced delivery systems remains a significant barrier to improve the efficacy, safety, and cost‐effectiveness of biotherapeutics.
Chunli Yang +9 more
wiley +1 more source
The Discovery of Erythropoietin
ASAIO Journal, 1993 A personal vignette of life as a resident and fellow at the Yale New Haven Hospital in the early 1950s follows. John Peters and his associates created a superb renal center at Yale New Haven, and they instilled in me a respect for quantitative measurements and a love for simple physiologic concepts. The environment was ideal for clinical and laboratory
openaire +4 more sources
United European Gastroenterology Journal, EarlyView.ABSTRACT Background The association between delayed post‐polypectomy bleeding and chronic kidney disease remains unclear. Objective This study investigated whether patients with chronic kidney disease are at an increased risk of delayed post‐polypectomy bleeding.
Hye Kyung Hyun +12 more
wiley +1 more source