Results 41 to 50 of about 80,709 (284)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Haemoglobin mass and running time trial performance after recombinant human erythropoietin administration in trained men [PDF]

, 2013
<p>Recombinant human erythropoietin (rHuEpo) increases haemoglobin mass (Hbmass) and maximal oxygen uptake (v˙ O2 max).</p> <p>Purpose: This study defined the time course of changes in Hbmass, v˙ O2 max as well as running time trial ...
Wondimu, D.H., Chatterji Tushar, McClure, J.D., Padmanabhan Neal, Daskalaki Evangelia, Anderson Martin, Patel Rajan K., Wondimu, Diresibachew H., Jérôme Durussel, Anderson, Martin, Tushar Chatterji, John D McClure, Patel, Rajan K., Pitsiladis, Yannis P., Pitsiladis, Yannis; id_orcid, Chatterji, Tushar, Martin Anderson, Rajan K Patel, Evangelia Daskalaki, Yannis P Pitsiladis, Pitsiladis Yannis P., Neal Padmanabhan, McClure John D., Padmanabhan, Neal, Anderson, M., Pitsiladis, Y.P., Daskalaki, Evangelia, Durussel, Jérôme, Daskalaki, E., Chatterji, T., Padmanabhan, N., Durussel, J., Diresibachew H Wondimu, McClure, John D., Patel, R.K., Durussel Jérôme, Wondimu Diresibachew H.   +36 more
core   +2 more sources

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]

, 2003
Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Eggen, BJL, Vellenga, E, Vellenga, Edo,, Vogelzang, Irma, Eggen, BJL; id_orcid, Vogelzang, Irma,, Wierenga, Albertus T.J., Wierenga, Albertus T.J.,, Eggen, Bart J.L.,   +8 more
core   +1 more source

Erythropoietin in the general population: reference ranges and clinical, biochemical and genetic correlates.

PLoS ONE, 2015
BackgroundAlthough erythropoietin has been used for decades in the treatment of anemia, data regarding endogenous levels in the general population are scarce.
Niels Grote Beverborg, Niek Verweij, Ijsbrand T Klip, Haye H van der Wal, Adriaan A Voors, Dirk J van Veldhuisen, Ron T Gansevoort, Stephan J L Bakker, Pim van der Harst, Peter van der Meer   +9 more
doaj   +1 more source

Serum erythropoietin levels, breast cancer and breast cancer-initiating cells

Breast Cancer Research, 2019
Background Cancer is frequently associated with tumor-related anemia, and many chemotherapeutic agents impair hematopoiesis, leading to impaired quality of life for affected patients.
Kruttika Bhat, Kiri Sandler, Sara Duhachek-Muggy, Claudia Alli, Fei Cheng, Neda A. Moatamed, Clara E. Magyar, Lin Du, Gang Li, Susan McCloskey, Erina Vlashi, Frank Pajonk   +11 more
doaj   +1 more source

Erythropoietin in the intensive care unit: beyond treatment of anemia [PDF]

, 2011
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Thiemermann, C, Massimo Collino, Muhammad M Yaqoob, Patel, NSA, Collino, M, Nimesh SA Patel, Christoph Thiemermann, Yaqoob, MM, Collino, Massimo   +8 more
core   +1 more source

Purification of Erythropoietin [PDF]

Proceedings of the National Academy of Sciences, 1971
Erythropoietin, the hormone that is the primary regulator of erythrocyte production, has been purified from anemic-sheep plasma, with a purification factor of more than 1 million. Gel electrophoresis shows that the major contaminant is desialated erythropoietin.
E, Goldwasser, C K, Kung
openaire   +2 more sources

Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice. [PDF]

PLoS ONE, 2017
Tmprss6-mutated mask mice display iron deficiency anemia and high expression of hepcidin. The aim of the study was to determine the effect of erythropoietin administration on proteins participating in the control of iron homeostasis in the liver and ...
Jana Frýdlová, Zuzana Rychtarčíková, Iuliia Gurieva, Martin Vokurka, Jaroslav Truksa, Jan Krijt   +5 more
doaj   +1 more source

Bench-to-bedside review: Erythropoietin and its derivatives as therapies in critical care [PDF]

, 2012
Author can archive publisher's pdf. Free via Creative Commons: CC-BENCHTOBEDSIDE-2.0.
Thiemermann, C, Patel, NSA, Nandra, KK
core   +1 more source

Use of Recombinant Human Erythropoietin in Renal Anemia in Children

Bangabandhu Sheikh Mujib Medical University Journal, 2009
Erythropoietin is a hormone highly effective as like as natural erythropoietin to maintain target hemoglobin and hematocrit level in renal anemia. Its advantage over blood transfusion has been proved by improving the quality of life and decreasing ...
Habibur Rahman, Salma Jahan, Afroza Begum, Golam Muinuddin, MM Hossain   +4 more
doaj   +1 more source