Results 31 to 40 of about 82,538 (246)

Serum erythropoietin levels, breast cancer and breast cancer-initiating cells

Breast Cancer Research, 2019
Background Cancer is frequently associated with tumor-related anemia, and many chemotherapeutic agents impair hematopoiesis, leading to impaired quality of life for affected patients.
Kruttika Bhat, Kiri Sandler, Sara Duhachek-Muggy, Claudia Alli, Fei Cheng, Neda A. Moatamed, Clara E. Magyar, Lin Du, Gang Li, Susan McCloskey, Erina Vlashi, Frank Pajonk   +11 more
doaj   +1 more source

Predictors of hyporesponsiveness to erythropoietin in prevalent hemodialysis patients and its association with mortality [PDF]

Revista Portuguesa de Nefrologia e Hipertensão, 2022
Introduction: Erythropoietin-stimulating agents hyporesponsiveness is common among hemodialysis patients. The aim was to analyze factors predictive of Erythropoietin-stimulating agent resistance and its association with mortality.
Marisa Roldão, Rui Duarte, Rachele Escoli, Hernâni Gonçalves, Flora Sofia, Karina Lopes   +5 more
doaj   +1 more source

Haemoglobin mass and running time trial performance after recombinant human erythropoietin administration in trained men [PDF]

, 2013
<p>Recombinant human erythropoietin (rHuEpo) increases haemoglobin mass (Hbmass) and maximal oxygen uptake (v˙ O2 max).</p> <p>Purpose: This study defined the time course of changes in Hbmass, v˙ O2 max as well as running time trial ...
Wondimu, D.H., Chatterji Tushar, McClure, J.D., Padmanabhan Neal, Daskalaki Evangelia, Anderson Martin, Patel Rajan K., Wondimu, Diresibachew H., Jérôme Durussel, Anderson, Martin, Tushar Chatterji, John D McClure, Patel, Rajan K., Pitsiladis, Yannis P., Pitsiladis, Yannis; id_orcid, Chatterji, Tushar, Martin Anderson, Rajan K Patel, Evangelia Daskalaki, Yannis P Pitsiladis, Pitsiladis Yannis P., Neal Padmanabhan, McClure John D., Padmanabhan, Neal, Anderson, M., Pitsiladis, Y.P., Daskalaki, Evangelia, Durussel, Jérôme, Daskalaki, E., Chatterji, T., Padmanabhan, N., Durussel, J., Diresibachew H Wondimu, McClure, John D., Patel, R.K., Durussel Jérôme, Wondimu Diresibachew H.   +36 more
core   +2 more sources

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Erythropoietin in the general population: reference ranges and clinical, biochemical and genetic correlates.

PLoS ONE, 2015
BackgroundAlthough erythropoietin has been used for decades in the treatment of anemia, data regarding endogenous levels in the general population are scarce.
Niels Grote Beverborg, Niek Verweij, Ijsbrand T Klip, Haye H van der Wal, Adriaan A Voors, Dirk J van Veldhuisen, Ron T Gansevoort, Stephan J L Bakker, Pim van der Harst, Peter van der Meer   +9 more
doaj   +1 more source

Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice. [PDF]

PLoS ONE, 2017
Tmprss6-mutated mask mice display iron deficiency anemia and high expression of hepcidin. The aim of the study was to determine the effect of erythropoietin administration on proteins participating in the control of iron homeostasis in the liver and ...
Jana Frýdlová, Zuzana Rychtarčíková, Iuliia Gurieva, Martin Vokurka, Jaroslav Truksa, Jan Krijt   +5 more
doaj   +1 more source

Cardioprotective Effects of Erythropoietin on Postresuscitation Myocardial Dysfunction in Appropriate Therapeutic Windows

, 2011
Objective: Erythropoietin has been noted for its cardioprotective effects . The objective of the study is to investigate its effects on postresuscitation myocardial dysfunction and therapeutic windows. Design: Randomized animal study.
HUANG, CHIEN-HUA;HSU, CHIUNG-YUAN;TSAI, MIN-SHAN;WANG, TZUNG-DAU;CHANG, WEI-TIEN;CHEN, WEN-JONE, 黃建華;許瓊元;蔡旼珊;王宗道;張維典;陳文鍾   +1 more
core   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Neopterin-induced Suppression of Erythropoietin Production In Vitro

Pteridines, 1995
The production of neopterin increases in several diseases with activation of the ceIlular immune response. As previously shown serum concentrations of neopterin are inversely correlated with blood hemoglobin concentrations in the anemia of hematological ...
Schobersberger W., Jelkmann W., Fandrey J., Frede S., Wachter H., Fuchs D.   +5 more
doaj   +1 more source