Results 101 to 110 of about 7,974,235 (283)

Human T cell responses to peptides of the Mycobacterium leprae 45-kD serine-rich antigen. [PDF]

, 2002
In order to identify T cell epitopes within the Mycobacterium leprae 45-kD serine-rich antigen, we analysed responses to overlapping 17-mer peptides encompassing the whole antigen in non-exposed UK controls, Pakistani leprosy patients and tuberculosis ...
Zafar, S, Dawood, G, Drijfhout, JW, Smith, S, Lopez, FV, Bothamley, G, Brahmbhatt, S, Hussain, R, Dockrell, HM, Ottenhoff, THM   +9 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila [PDF]

, 2014
Development of effective malaria vaccines is hampered by the problem of producing correctly folded Plasmodium proteins for use as vaccine components.
David R. Cavanagh, Hartmann Marcus W. W., Eleni-Muus Janna, Graeme J M Cowan, Ingo Aldag, Hartmann, Marcus W W, Samuel, Kay, Aldag Ingo, Samuel Kay, Alison M Creasey, Bockau, Ulrike, Cavanagh, David R, Alison M. Creasey, Creasey Alison M., Eleni-Muus, Janna, Cavanagh David R., Graeme J. M. Cowan, Cowan, Graeme J M; id_orcid, Ulrike Bockau, David R Cavanagh, Creasey, Alison M, Kay Samuel, Cowan Graeme J. M., Aldag, Ingo, Janna Eleni-Muus, Marcus W. W. Hartmann, Marcus W W Hartmann, Bockau Ulrike   +27 more
core   +2 more sources

Late-phase expression of a murine cytomegalovirus immediate-early antigen recognized by cytolytic T lymphocytes [PDF]

, 1986
The cloned murine cytolytic T-lymphocyte line IE1-IL and several sublines detect a murine cytomegalovirus immediate-early (IE) membrane determinant in conjunction with Ld class I major histocompatibility glycoprotein.
Reddehase, Matthias J., Fibi, Mathias R., Koszinowski, Ulrich H., Keil, Günther M.   +3 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Regulation of dendritic cell immune function and maturation by the recombinant antigen p53 of Trichinella spiralis

Parasites & Vectors
Background The excretory–secretory (ES) antigen of Trichinella spiralis (T. spiralis) has garnered significant attention owing to its notable immunomodulatory activities, particularly its ability to regulate the maturation of dendritic cells (DCs).
Xuhong Yuan, Xuejiao Yang, Caixia Han
doaj   +1 more source

Field evaluation of ELISA using Wuchereria bancrofti mf ES antigen for bancroftian filariasis.

Bulletin of the World Health Organization, 1985
An enzyme-linked immunosorbent assay using Wuchereria bancrofti microfilarial excretory-secretory antigen was used in field studies to screen blood samples collected on filter-paper from persons residing in areas endemic for bancroftian filariasis. This assay system, when compared with examination of night wet blood smears for microfilariae, gave a ...
B C, Harinath, A, Malhotra, S N, Ghirnikar, S D, Annadate, V P, Isaacs, M S, Bharti   +5 more
openaire   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source