Results 1 to 10 of about 9,987 (185)

Helminth Antigens Modulate Virus-Induced Activation of CD154 (CD40L) Expression on T Cells in Onchocerca volvulus-Infected Individuals [PDF]

Pathogens
Background: The interaction between helminth and viral infections has important implications for understanding viral disease outcomes and vaccine efficacy in helminth-endemic regions.
Brice Armel Nembot Fogang, Kathrin Arndts, Tomabu Adjobimey, Michael Owusu, Vera Serwaa Opoku, Derrick Adu Mensah, John Boateng, Jubin Osei-Mensah, Julia Meyer, Ute Klarmann-Schulz, Sacha Horn, Inge Kroidl, Alexander Y. Debrah, Achim Hoerauf, Manuel Ritter, Linda B. Debrah   +15 more
doaj   +2 more sources

Ascaris lumbricoides antigen exposure modulates T cell activation via regulation of IL-15Rα expression, STAT5 phosphorylation, and promotes differentiation of BCL6low B cells [PDF]

Frontiers in Immunology
BackgroundMycobacterium tuberculosis (Mtb) causes active tuberculosis (TB) in approximately 10 million people annually, resulting in 1.6 million deaths.
Giggil Pushpamithran, Daniel Appelgren, Robert H. Gilman, Robert H. Gilman, Robert Blomgran   +4 more
doaj   +2 more sources

Identification of a persistent Ascaris-derived Kalirin epitope associated with chronic T cell activation in the lung. [PDF]

PLoS Neglected Tropical Diseases
Ascariasis remains a dominant global health burden due to its vast prevalence and associated morbidity. The obligatory migration of Ascaris larvae through pulmonary tissue triggers intense type-2 inflammation which typically presents as acute allergic ...
Yifan Wu, Leroy Versteeg, Meng-Chih Wu, Jill E Weatherhead   +3 more
doaj   +2 more sources

Species dependent impact of helminth-derived antigens on human macrophages infected with Mycobacterium tuberculosis: Direct effect on the innate anti-mycobacterial response. [PDF]

PLoS Neglected Tropical Diseases, 2017
BACKGROUND:In countries with a high prevalence of tuberculosis there is high coincident of helminth infections that might worsen disease outcome. While Mycobacterium tuberculosis (Mtb) gives rise to a pro-inflammatory Th1 response, a Th2 response is ...
Naomi Aira, Anna-Maria Andersson, Susmita K Singh, Derek M McKay, Robert Blomgran   +4 more
doaj   +1 more source

House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins.

PLoS Pathogens, 2021
The establishment of type 2 responses driven by allergic sensitization prior to exposure to helminth parasites has demonstrated how tissue-specific responses can protect against migrating larval stages, but, as a consequence, allow for immune-mediated ...
Pedro Henrique Gazzinelli-Guimaraes, Sasisekhar Bennuru, Rafael de Queiroz Prado, Alessandra Ricciardi, Joshua Sciurba, Jonah Kupritz, Matthew Moser, Olena Kamenyeva, Thomas B Nutman   +8 more
doaj   +1 more source

Diffusion Chambers for the Collection of Helminth Antigens [PDF]

Nature, 1963
IN comparing the immunological responsiveness, in relation to a particular nematode, of old-established hosts on one hand and newly established hosts on the other1, it was necessary to obtain an antigen which could be presumed to have been immunologically active over evolutionary time, that is, a natural product of normal infection.
J F, SPRENT, R S, SCOTT, H, TIMOURIAN
openaire   +2 more sources

Helminth antigens differentially modulate the activation of CD4+ and CD8+ T lymphocytes of convalescent COVID-19 patients in vitro

BMC Medicine, 2022
Background The coronavirus disease 2019 (COVID-19) is a respiratory disease caused by SARS-CoV-2, a recently discovered strain of coronavirus. The virus has spread rapidly, causing millions of death worldwide.
Tomabu Adjobimey, Julia Meyer, Vedrana Terkeš, Marijo Parcina, Achim Hoerauf   +4 more
doaj   +1 more source

Helminth Antigen Exposure Enhances Early Immune Control of Mycobacterium tuberculosis in Monocytes and Macrophages

Journal of Innate Immunity, 2020
Helminth and Mycobacterium tuberculosis (Mtb) coinfection is common and suggested to influence the risk of developing active tuberculosis (TB). It is known that helminths in contrast to TB induce a strong Th2 response in the host.
Shambhuprasad Kotresh Togarsimalemath, Giggil Pushpamithran, Thomas Schön, Olle Stendahl, Robert Blomgran   +4 more
doaj   +1 more source

Defined Intestinal Regions Are Drained by Specific Lymph Nodes That Mount Distinct Th1 and Th2 Responses Against Schistosoma mansoni Eggs

Frontiers in Immunology, 2020
The balance of type 1 and type 2 immune responses plays a crucial role in anti-helminth immunity and can either support chronic infection or drive type 2 mediated expulsion of the parasite. Helminth antigens and secreted molecules directly influence this
Johannes U. Mayer, Johannes U. Mayer, Sheila L. Brown, Andrew S. MacDonald, Simon W. Milling   +4 more
doaj   +1 more source

Soil-Transmitted Helminth Vaccines: Are We Getting Closer?

Frontiers in Immunology, 2020
Parasitic helminths infect over one-fourth of the human population resulting in significant morbidity, and in some cases, death in endemic countries.
Ayat Zawawi, Kathryn J. Else
doaj   +1 more source