Results 1 to 10 of about 20,135 (182)

Helminth Antigens Modulate Virus-Induced Activation of CD154 (CD40L) Expression on T Cells in Onchocerca volvulus-Infected Individuals [PDF]

Pathogens
Background: The interaction between helminth and viral infections has important implications for understanding viral disease outcomes and vaccine efficacy in helminth-endemic regions.
Brice Armel Nembot Fogang, Kathrin Arndts, Tomabu Adjobimey, Michael Owusu, Vera Serwaa Opoku, Derrick Adu Mensah, John Boateng, Jubin Osei-Mensah, Julia Meyer, Ute Klarmann-Schulz, Sacha Horn, Inge Kroidl, Alexander Y. Debrah, Achim Hoerauf, Manuel Ritter, Linda B. Debrah   +15 more
doaj   +2 more sources

Ascaris lumbricoides antigen exposure modulates T cell activation via regulation of IL-15Rα expression, STAT5 phosphorylation, and promotes differentiation of BCL6low B cells [PDF]

Frontiers in Immunology
BackgroundMycobacterium tuberculosis (Mtb) causes active tuberculosis (TB) in approximately 10 million people annually, resulting in 1.6 million deaths.
Giggil Pushpamithran, Daniel Appelgren, Robert H. Gilman, Robert H. Gilman, Robert Blomgran   +4 more
doaj   +2 more sources

Mixed Signals: T Cells as Architects of IgE Immunity. [PDF]

Immunol Rev
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Tierney AL, Bezerra WP, Eisenbarth SC, Williams A.   +3 more
europepmc   +2 more sources

Species dependent impact of helminth-derived antigens on human macrophages infected with Mycobacterium tuberculosis: Direct effect on the innate anti-mycobacterial response. [PDF]

PLoS Neglected Tropical Diseases, 2017
BACKGROUND:In countries with a high prevalence of tuberculosis there is high coincident of helminth infections that might worsen disease outcome. While Mycobacterium tuberculosis (Mtb) gives rise to a pro-inflammatory Th1 response, a Th2 response is ...
Naomi Aira, Anna-Maria Andersson, Susmita K Singh, Derek M McKay, Robert Blomgran   +4 more
doaj   +1 more source

House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins.

PLoS Pathogens, 2021
The establishment of type 2 responses driven by allergic sensitization prior to exposure to helminth parasites has demonstrated how tissue-specific responses can protect against migrating larval stages, but, as a consequence, allow for immune-mediated ...
Pedro Henrique Gazzinelli-Guimaraes, Sasisekhar Bennuru, Rafael de Queiroz Prado, Alessandra Ricciardi, Joshua Sciurba, Jonah Kupritz, Matthew Moser, Olena Kamenyeva, Thomas B Nutman   +8 more
doaj   +1 more source

Helminth antigens differentially modulate the activation of CD4+ and CD8+ T lymphocytes of convalescent COVID-19 patients in vitro

BMC Medicine, 2022
Background The coronavirus disease 2019 (COVID-19) is a respiratory disease caused by SARS-CoV-2, a recently discovered strain of coronavirus. The virus has spread rapidly, causing millions of death worldwide.
Tomabu Adjobimey, Julia Meyer, Vedrana Terkeš, Marijo Parcina, Achim Hoerauf   +4 more
doaj   +1 more source

Risk Factors for Soil-Transmitted Helminth Infections during the First 3 Years of Life in the Tropics; Findings from a Birth Cohort. [PDF]

, 2014
Background: Soil-transmitted helminths (STH) infect more than 2 billion humans worldwide, causing significant morbidity in children. There are few data on the epidemiology and risk factors for infection in pre-school children. To investigate risk factors
A Amberbir, A Moncayo, Alejandro Rodriguez, C Figueiredo, C Steel, Carlos Sandoval, E Roy, F Bieri, I Guadalupe, I Malhotra, Irene Guadalupe, J Bukusuba, K Tanaka, M Albonico, M-E Sackey, Maria Elena Bottazzi, Martha Chico, N De Silva, Nely Broncano, P Cooper, P Cooper, P Hotez, P Lammie, P Muniz, Philip J. Cooper, R Mehta, R Oberhalman, S Kounnavong, S Williams-Blangero, S Williams-Blangero, Stefanie K. Menzies, T Cupedo, T Rajan, X Wang, Y Belyhun   +34 more
core   +21 more sources

Helminth Antigen Exposure Enhances Early Immune Control of Mycobacterium tuberculosis in Monocytes and Macrophages

Journal of Innate Immunity, 2020
Helminth and Mycobacterium tuberculosis (Mtb) coinfection is common and suggested to influence the risk of developing active tuberculosis (TB). It is known that helminths in contrast to TB induce a strong Th2 response in the host.
Shambhuprasad Kotresh Togarsimalemath, Giggil Pushpamithran, Thomas Schön, Olle Stendahl, Robert Blomgran   +4 more
doaj   +1 more source

Defined Intestinal Regions Are Drained by Specific Lymph Nodes That Mount Distinct Th1 and Th2 Responses Against Schistosoma mansoni Eggs

Frontiers in Immunology, 2020
The balance of type 1 and type 2 immune responses plays a crucial role in anti-helminth immunity and can either support chronic infection or drive type 2 mediated expulsion of the parasite. Helminth antigens and secreted molecules directly influence this
Johannes U. Mayer, Johannes U. Mayer, Sheila L. Brown, Andrew S. MacDonald, Simon W. Milling   +4 more
doaj   +1 more source

How to train your myeloid cells: a way forward for helminth vaccines?

Frontiers in Immunology, 2023
Soil-transmitted helminths affect approximately 1.5 billion people worldwide. However, as no vaccine is currently available for humans, the current strategy for elimination as a public health problem relies on preventive chemotherapy.
Rory Doolan, Rory Doolan, Namitha Putananickal, Namitha Putananickal, Lucienne Tritten, Lucienne Tritten, Lucienne Tritten, Tiffany Bouchery, Tiffany Bouchery   +8 more
doaj   +1 more source