Results 21 to 30 of about 20,135 (182)

Necator americanus and helminth co-infections: further down-modulation of hookworm-specific type 1 immune responses.

PLoS Neglected Tropical Diseases, 2011
BackgroundHelminth co-infection in humans is common in tropical regions of the world where transmission of soil-transmitted helminths such as Ascaris lumbricoides, Trichuris trichiura, and the hookworms Necator americanus and Ancylostoma duodenale as ...
Stefan Michael Geiger, Neal Douglas Edward Alexander, Ricardo Toshio Fujiwara, Simon Brooker, Bonnie Cundill, David Joseph Diemert, Rodrigo Correa-Oliveira, Jeffrey Michael Bethony   +7 more
doaj   +1 more source

A Comparative Analysis of the Protein Cargo of Extracellular Vesicles from Helminth Parasites

Life, 2023
Helminth parasites cause debilitating—sometimes fatal—diseases in humans and animals. Despite their impact on global health, mechanisms underlying host–parasite interactions are still poorly understood.
María Eugenia Ancarola, Lucas L. Maldonado, Lucía C. A. García, Gisela R. Franchini, Gustavo Mourglia-Ettlin, Laura Kamenetzky, Marcela A. Cucher   +6 more
doaj   +1 more source

Human Schistosome Infection and Allergic Sensitisation [PDF]

, 2012
Several field studies have reported an inverse relationship between the prevalence of helminth infections and that of allergic sensitisation/atopy. Recent studies show that immune responses induced by helminth parasites are, to an extent, comparable to ...
Mutapi, Francisca, Rujeni, Nadine, Taylor, David W.   +2 more
core   +3 more sources

Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study)

BMC Infectious Diseases, 2010
Background Given that helminth infections are thought to have strong immunomodulatory activity, the question whether helminth infections might affect responses to malaria antigens needs to be addressed.
Sutanto Inge, Wahyuni Sitti, Djuardi Yenny, Wibowo Heri, Uh Hae, Ariawan Iwan, Lell Bertrand, Wammes Linda J, Hamid Firdaus, Prasetyani Margaretta A, Wiria Aprilianto E, May Linda, Luty Adrian JF, Verweij Jaco J, Sartono Erliyani, Yazdanbakhsh Maria, Supali Taniawati   +16 more
doaj   +1 more source

Impact of Helminth Infections during Pregnancy on Vaccine Immunogenicity in Gabonese Infants

Vaccines, 2020
Helminth infections are common in sub-Saharan Africa. Besides direct clinical effects, a bias towards a T helper type 2 (Th2) cell immune response is observed.
Judith Flügge, Ayôla Akim Adegnika, Yabo Josiane Honkpehedji, Thaisa L. Sandri, Esther Askani, Gédéon Prince Manouana, Marguerite Massinga Loembe, Sina Brückner, Mohamed Duali, Johannes Strunk, Benjamin Mordmüller, Selidji Todagbe Agnandji, Bertrand Lell, Peter G. Kremsner, Meral Esen   +14 more
doaj   +1 more source

Helminth infections coincident with active pulmonary tuberculosis inhibit mono- and multifunctional CD4+ and CD8+ T cell responses in a process dependent on IL-10. [PDF]

PLoS Pathogens, 2014
Tissue invasive helminth infections and tuberculosis (TB) are co-endemic in many parts of the world and can trigger immune responses that might antagonize each other.
Parakkal Jovvian George, Rajamanickam Anuradha, Nathella Pavan Kumar, Rathinam Sridhar, Vaithilingam V Banurekha, Thomas B Nutman, Subash Babu   +6 more
doaj   +1 more source

Helminth parasites and immune regulation [version 1; referees: 2 approved]

F1000Research, 2018
Helminth parasites are complex metazoans that belong to different taxonomic families but that collectively share the capacity to downregulate the host immune response directed toward themselves (parasite-specific immunoregulation).
Pedro H. Gazzinelli-Guimaraes, Thomas B. Nutman   +1 more
doaj   +1 more source

Exploratory analysis of the effect of helminth infection on the immunogenicity and efficacy of the asexual blood-stage malaria vaccine candidate GMZ2.

PLoS Neglected Tropical Diseases, 2021
BackgroundHelminths can modulate the host immune response to Plasmodium falciparum and can therefore affect the risk of clinical malaria. We assessed here the effect of helminth infections on both the immunogenicity and efficacy of the GMZ2 malaria ...
Odilon Nouatin, Juliana Boex Mengue, Jean Claude Dejon-Agobé, Rolf Fendel, Javier Ibáñez, Ulysse Ateba Ngoa, Jean Ronald Edoa, Bayodé Roméo Adégbité, Yabo Josiane Honkpéhédji, Jeannot Fréjus Zinsou, Aurore Bouyoukou Hounkpatin, Kabirou Moutairou, Andreas Homoet, Meral Esen, Andrea Kreidenweiss, Stephen L Hoffman, Michael Theisen, Adrian J F Luty, Bertrand Lell, Selidji Todagbe Agnandji, Ghyslain Mombo-Ngoma, Michael Ramharter, Peter Kremsner, Benjamin Mordmüller, Ayôla Akim Adegnika   +24 more
doaj   +1 more source

A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1-polarizing activity [PDF]

, 2017
Fasciolosis is a trematode zoonosis of interest in public health and cattle production. We report here the immunostimulatory effect of a 66 mer mucin-like peptide from Fasciola hepatica (Fhmuc), which synergizes with lipopolysaccharide (LPS) to promote ...
Brossard, Natalie, Carmona, Carlos, Dergan Dylon, Leonardo Sebastian, Freire, Teresa, Noya, Verónica, Rabinovich, Gabriel Adrián, Rodríguez, Ernesto   +6 more
core   +1 more source

Does helminth activation of Toll-Like Receptors modulate immune response in Multiple Sclerosis patients?

Frontiers in Cellular and Infection Microbiology, 2012
Multiple sclerosis (MS) is an inflammatory autoimmune demyelinating disease affecting the Central Nervous System, in which Th1 and Th17 cells appear to recognize and react against certain myelin sheath components.Epidemiological evidence has accumulated ...
Jorge eCorreale, Mauricio Franco Farez
doaj   +1 more source