Results 31 to 40 of about 195,323 (225)

Antigens of parasitic helminths in diagnosis, protection and pathology

Parasitology, 1989
SUMMARYA thorough study of parasitic helminth antigens is a pre-requisite for control programmes based on accurate immunochemical diagnosis, protection by vaccination and perhaps immune modulation to diminish pathological sequelae. Studies should be directed at the identification of those stage- or age-specific surface, secreted and somatic antigens ...
R M, Parkhouse, L J, Harrison
openaire   +2 more sources

Impact of co-infections and BCG immunisation on immune responses among household contacts of tuberculosis patients in a Ugandan cohort. [PDF]

, 2014
BACKGROUND: Tuberculosis incidence in resource poor countries remains high. We hypothesized that immune modulating co-infections such as helminths, malaria, and HIV increase susceptibility to latent tuberculosis infection (LTBI), thereby contributing to ...
Katamba, Achilles, Moses Egesa, Levin, Jonathan, Jonathan Levin, Biraro, Irene A, Moses Joloba, Stephen Cose, Alison M Elliott, Irene A Biraro, Achilles Katamba, Egesa, Moses, Hazel M Dockrell, Cose, Stephen, Frederic Toulza, Joloba, Moses, Elliott, Alison M, Toulza, Frederic, Dockrell, Hazel M, Steven Smith, Smith, Steven   +19 more
core   +1 more source

Does helminth activation of Toll-Like Receptors modulate immune response in Multiple Sclerosis patients?

Frontiers in Cellular and Infection Microbiology, 2012
Multiple sclerosis (MS) is an inflammatory autoimmune demyelinating disease affecting the Central Nervous System, in which Th1 and Th17 cells appear to recognize and react against certain myelin sheath components.Epidemiological evidence has accumulated ...
Jorge eCorreale, Mauricio Franco Farez
doaj   +1 more source

Impact of Helminth Infections during Pregnancy on Vaccine Immunogenicity in Gabonese Infants

Vaccines, 2020
Helminth infections are common in sub-Saharan Africa. Besides direct clinical effects, a bias towards a T helper type 2 (Th2) cell immune response is observed.
Judith Flügge, Ayôla Akim Adegnika, Yabo Josiane Honkpehedji, Thaisa L. Sandri, Esther Askani, Gédéon Prince Manouana, Marguerite Massinga Loembe, Sina Brückner, Mohamed Duali, Johannes Strunk, Benjamin Mordmüller, Selidji Todagbe Agnandji, Bertrand Lell, Peter G. Kremsner, Meral Esen   +14 more
doaj   +1 more source

Helminth infections coincident with active pulmonary tuberculosis inhibit mono- and multifunctional CD4+ and CD8+ T cell responses in a process dependent on IL-10. [PDF]

PLoS Pathogens, 2014
Tissue invasive helminth infections and tuberculosis (TB) are co-endemic in many parts of the world and can trigger immune responses that might antagonize each other.
Parakkal Jovvian George, Rajamanickam Anuradha, Nathella Pavan Kumar, Rathinam Sridhar, Vaithilingam V Banurekha, Thomas B Nutman, Subash Babu   +6 more
doaj   +1 more source

A Comparative Analysis of the Protein Cargo of Extracellular Vesicles from Helminth Parasites

Life, 2023
Helminth parasites cause debilitating—sometimes fatal—diseases in humans and animals. Despite their impact on global health, mechanisms underlying host–parasite interactions are still poorly understood.
María Eugenia Ancarola, Lucas L. Maldonado, Lucía C. A. García, Gisela R. Franchini, Gustavo Mourglia-Ettlin, Laura Kamenetzky, Marcela A. Cucher   +6 more
doaj   +1 more source

The immunomodulatory properties of helminth-derived products on dendritic cell maturation and function [PDF]

, 2009
Parasitic worms and molecules derived from them drive Th2/Treg immune responses in mammalian hosts and have powerful anti-inflammatory properties which are shown to have therapeutic effects on inflammatory diseases.
Dowling, David J.
core   +2 more sources

Priming dendritic cells for Th2 polarization: lessons learned from helminths and implications for metabolic disorders

Frontiers in Immunology, 2014
Nearly one quarter of the world’s population is infected with helminth parasites. A common feature of helminth infections is the manifestation of a type 2 immune response, characterized by T helper 2 (Th2) cells that mediate anti-helminth immunity.
Leonie eHussaarts, Maria eYazdanbakhsh, Bruno eGuigas, Bruno eGuigas   +3 more
doaj   +1 more source

Exploratory analysis of the effect of helminth infection on the immunogenicity and efficacy of the asexual blood-stage malaria vaccine candidate GMZ2.

PLoS Neglected Tropical Diseases, 2021
BackgroundHelminths can modulate the host immune response to Plasmodium falciparum and can therefore affect the risk of clinical malaria. We assessed here the effect of helminth infections on both the immunogenicity and efficacy of the GMZ2 malaria ...
Odilon Nouatin, Juliana Boex Mengue, Jean Claude Dejon-Agobé, Rolf Fendel, Javier Ibáñez, Ulysse Ateba Ngoa, Jean Ronald Edoa, Bayodé Roméo Adégbité, Yabo Josiane Honkpéhédji, Jeannot Fréjus Zinsou, Aurore Bouyoukou Hounkpatin, Kabirou Moutairou, Andreas Homoet, Meral Esen, Andrea Kreidenweiss, Stephen L Hoffman, Michael Theisen, Adrian J F Luty, Bertrand Lell, Selidji Todagbe Agnandji, Ghyslain Mombo-Ngoma, Michael Ramharter, Peter Kremsner, Benjamin Mordmüller, Ayôla Akim Adegnika   +24 more
doaj   +1 more source

Helminth allergens, parasite-specific IgE and its protective role in human immunity

Frontiers in Immunology, 2014
The Th2 immune response, culminating in eosinophilia and IgE production, is not only characteristic of allergy but also of infection by parasitic worms (helminths).
Colin Matthew Fitzsimmons, Franco Harald Falcone, David W Dunne   +2 more
doaj   +1 more source