Results 41 to 50 of about 9,987 (185)

Helminth antigen-based strategy to ameliorate inflammation in an experimental model of colitis [PDF]

Clinical and Experimental Immunology, 2008
SummaryInflammatory bowel disease (IBD) is the most common and serious chronic inflammatory condition of the gut. Among the distinct T helper (Th) cell subsets, a Th1 type response is associated predominantly with Crohn's disease (CD) while helminth infections generate a strong Th2 type response. IBD is most prevalent in developed countries but rare in
Y, Motomura, H, Wang, Y, Deng, R T, El-Sharkawy, E F, Verdu, W I, Khan   +5 more
openaire   +2 more sources

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Plasmodium falciparum and Helminth Coinfections Increase IgE and Parasite-Specific IgG Responses

Microbiology Spectrum, 2021
Coinfection with Plasmodium falciparum and helminths may impact the immune response to these parasites because they induce different immune profiles. We studied the effects of coinfections on the antibody profile in a cohort of 715 Mozambican children ...
Rebeca Santano, Rocío Rubio, Berta Grau-Pujol, Valdemiro Escola, Osvaldo Muchisse, Inocência Cuamba, Marta Vidal, Pau Cisteró, Gemma Ruiz-Olalla, Ruth Aguilar, Maria Demontis, Jose Carlos Jamine, Anélsio Cossa, Charfudin Sacoor, Jorge Cano, Luis Izquierdo, Chetan E. Chitnis, Ross L. Coppel, Virander Chauhan, David Cavanagh, Sheetij Dutta, Evelina Angov, Deepak Gaur, Lisette van Lieshout, Bin Zhan, Jose Muñoz, Gemma Moncunill, Carlota Dobaño   +27 more
doaj   +1 more source

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

TLRs, Treg and B cells, an interplay of regulation during helminth infection

Frontiers in Immunology, 2012
Commonly described as masters of regulation parasitic helminth infections provide a fascinating insight into the complexity of our immune system. As with many other pathogens helminths have developed complex evasion strategies and the immune response of ...
Laura E Layland, Isis eLudwig-Portugall
doaj   +1 more source

IL-10- and TGFβ-mediated Th9 Responses in a Human Helminth Infection. [PDF]

PLoS Neglected Tropical Diseases, 2016
Th9 cells are a subset of CD4+ T cells that express the protoypical cytokine, IL-9. Th9 cells are known to effect protective immunity in animal models of intestinal helminth infections.
Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Jeeva Jagannathan, Chandrakumar Dolla, Paul Kumaran, Thomas B Nutman, Subash Babu   +7 more
doaj   +1 more source

An Enteric Helminth Infection Protects Against an Allergic Response to Dietary Antigen [PDF]

The Journal of Immunology, 2002
Abstract Although helminths induce a polarized Th2 response they have been shown, in clinical studies, to confer protection against allergies. To elucidate the basis for this paradox, we have examined the influence of an enteric helminth infection on a model of food allergy.
Mohamed Elfatih H, Bashir, Peter, Andersen, Ivan J, Fuss, Hai Ning, Shi, Cathryn, Nagler-Anderson   +4 more
openaire   +2 more sources

The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT CD4+ T cells orchestrate adaptive immunity against respiratory viruses through functionally distinct subsets, yet the qualitative differences between vaccine‐ and infection‐induced responses remain incompletely understood. This review summarizes current evidence on how CD4+ T cell subsets shape the magnitude, breadth, and durability of ...
Masato Kubo
wiley   +1 more source

Immunomodulatory Effects of Trichinella spiralis on Streptozotocin-Induced Diabetes in Mice: Prophylactic and Therapeutic Implications [PDF]

Delta Journal of Science
The growing burden of diabetes mellitus type 1 (T1-DM), stresses innovative therapeutic strategies. Helminth infections, such as Trichinella spiralis (T. spiralis), show powerful immunomodulatory effects that may mitigate autoimmune conditions.
Kareem Bakr, Nahla Radwan, Mohamed Mohamed, Mona Elwan   +3 more
doaj   +1 more source

Myeloid-Derived Suppressor Cells: The Expanding World of Helminth Modulation of the Immune System

Frontiers in Immunology, 2022
Infection with helminths or parasitic worms are highly prevalent worldwide especially in developing regions. Helminths cause chronic infections that are associated with suppression of immune responses to unrelated pathogens, vaccines, and by-stander ...
Mary M. Stevenson, Mary M. Stevenson, Rajesh M. Valanparambil, Mifong Tam   +3 more
doaj   +1 more source