Results 61 to 70 of about 9,987 (185)

Spinal Cord Schistosomiasis: A Rare and Severe Presentation of a Common Disease—A Case Report and Review of Literature

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Spinal cord schistosomiasis (SCS) is a rare but potentially disabling manifestation of Schistosoma mansoni infection caused by ectopic deposition of parasite eggs within the spinal cord via Batson's vertebral venous plexus, resulting in granulomatous inflammation and neurological injury.
Elham Sany Shemsu, Thomas Asfaw Atnafu, Eskedar Ferdu Azerefegne, Ilili Amin Aliye   +3 more
wiley   +1 more source

From Parasite to Therapy: Immunomodulatory Effects of a Trichuris trichiura Derived Recombinant Protein in Allergic Airway Disease

Clinical &Experimental Allergy, EarlyView.
Jessica Cristiane da Conceição de Andrade, Eduardo Santos da Silva, Jennifer Emily Anunciação Sousa, Jade Liz Ferreira Mendes Souza, Carolina Melo Orrico‐Ferreira, Lorena Miranda Souza, Raphael Chagas Silva, Silvia Letícia Bispo dos Santos, Antônio Márcio Santana Fernandes, João Vitor Borges Rios, Paulo Emílio Oliveira Cruz, Vítor Lima Miranda Melo, Emília Maria Medeiros de Andrade Belitardo, Luís Gustavo Carvalho Pacheco, Carina Silva Pinheiro   +14 more
wiley   +1 more source

Safety and immunogenicity of an adjuvanted human onchocerciasis vaccine candidate, OvMANE1: preclinical evaluation in a mice model

Clinical &Translational Immunology, Volume 15, Issue 7, 2026.
OvMANE1 formulated with Freund's adjuvant was safe and elicited strong humoral and cellular immune responses, including significant IgG and leukocyte activation. These findings highlight OvMANE1 as a promising multi‐epitope vaccine candidate for advancing onchocerciasis prevention.
Derrick Neba Nebangwa, Mary Teke Efeti, Sonia M. E. Momnougui, Cabirou Mounchili Shintouo, Robert Adamu Shey, Rene Bilingwe Ayiseh, Fidele Ntie‐Kang, Stephen Mbigha Ghogomu   +7 more
wiley   +1 more source

The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection

Cell Reports, 2018
Summary: Inflammasomes promote immunity to microbial pathogens by regulating the function of IL-1-family cytokines such as IL-18 and IL-1β. However, the roles for inflammasomes during parasitic helminth infections remain unclear. We demonstrate that mice
Rafid Alhallaf, Zainab Agha, Catherine M. Miller, Avril A.B. Robertson, Javier Sotillo, John Croese, Matthew A. Cooper, Seth L. Masters, Andreas Kupz, Nicholas C. Smith, Alex Loukas, Paul R. Giacomin   +11 more
doaj   +1 more source

Complement Factor H‐Based Therapeutics: A Comprehensive Overview

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Complement factor H is a central regulator of the complement system and thus a target for therapeutic intervention. In this review, we provide an overview of past and current factor H‐based therapeutic concepts and modalities to treat complement‐mediated diseases.
Sebastiaan M. W. R. Hamers, Emmy J. Buter, Richard B. Pouw   +2 more
wiley   +1 more source

Caecal Epithelium‐Derived Thymic Stromal Lymphopoietin is not Required for Protective Immunity Against Whipworm

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Immunity to Trichuris muris infection is unimpacted by epithelial knockout of TSLP expression. Imaging of transcription in the caecum reveals Tslp transcription throughout infection in EpCAM‐, Foxl1‐, Ccl24‐ lamina propria‐resident cells, contributing during the expulsion phase of infection. ABSTRACT Recent research examining classical type two alarmin
Connor P. Lynch, Seona Thompson, Erin‐Claire Pallott, Laura Campbell, Sang Hun Lee, Richard K. Grencis   +5 more
wiley   +1 more source

Immuno-therapeutic and prophylactic potential of Trichinella spiralis antigens for inflammatory bowel diseases

Food and Waterborne Parasitology
Ulcerative colitis (UC), a severe chronic inflammatory disorder of the colon, is one of the inflammatory bowel diseases (IBD) that affects humans and several domestic animal species, including cats and dogs.
Majed H. Wakid, Walaa A. El Kholy, Muslimah N. Alsulami, Eman S. El-Wakil   +3 more
doaj   +1 more source

The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity

MedComm, Volume 7, Issue 7, July 2026.
Regulatory B cells maintain immune homeostasis via suppressive cytokines and surface molecules like PD‐L1. While beneficially suppressing autoimmunity and promoting transplant tolerance, these identical mechanisms detrimentally attenuate antipathogen and antitumor immune responses.
Anni Feng, Qilong Li, Ning Jiang, Qijun Chen   +3 more
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

The impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: Secondary analysis of a randomised controlled trial.

PLoS Neglected Tropical Diseases, 2017
BackgroundChronic parasitic infections are associated with active immunomodulation which may include by-stander effects on unrelated antigens. It has been suggested that pre-natal exposure to parasitic infections in the mother impacts immunological ...
Stephen Nash, Alexander J Mentzer, Swaib A Lule, Dennison Kizito, Gaby Smits, Fiona R M van der Klis, Alison M Elliott   +6 more
doaj   +1 more source