Results 61 to 70 of about 195,323 (225)

Down regulation of the TCR complex CD3 ζ-chain on CD3+ T cells: a potential mechanism for helminth mediated immune modulation

Frontiers in Immunology, 2015
The CD3ζ forms part of the T cell receptor (TCR) where it plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways leading to T cell effector functions.
Laura Jane Appleby, Norman eNausch, Claire Deirdre Bourke, Francisca eMutapi, Nicholas eMidzi, Takafira eMduluza, Judith eAllen, Francesca eHeard, Louise eErskine   +8 more
doaj   +1 more source

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

TLRs, Treg and B cells, an interplay of regulation during helminth infection

Frontiers in Immunology, 2012
Commonly described as masters of regulation parasitic helminth infections provide a fascinating insight into the complexity of our immune system. As with many other pathogens helminths have developed complex evasion strategies and the immune response of ...
Laura E Layland, Isis eLudwig-Portugall
doaj   +1 more source

IL-10- and TGFβ-mediated Th9 Responses in a Human Helminth Infection. [PDF]

PLoS Neglected Tropical Diseases, 2016
Th9 cells are a subset of CD4+ T cells that express the protoypical cytokine, IL-9. Th9 cells are known to effect protective immunity in animal models of intestinal helminth infections.
Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Jeeva Jagannathan, Chandrakumar Dolla, Paul Kumaran, Thomas B Nutman, Subash Babu   +7 more
doaj   +1 more source

Plasmodium falciparum and Helminth Coinfections Increase IgE and Parasite-Specific IgG Responses

Microbiology Spectrum, 2021
Coinfection with Plasmodium falciparum and helminths may impact the immune response to these parasites because they induce different immune profiles. We studied the effects of coinfections on the antibody profile in a cohort of 715 Mozambican children ...
Rebeca Santano, Rocío Rubio, Berta Grau-Pujol, Valdemiro Escola, Osvaldo Muchisse, Inocência Cuamba, Marta Vidal, Pau Cisteró, Gemma Ruiz-Olalla, Ruth Aguilar, Maria Demontis, Jose Carlos Jamine, Anélsio Cossa, Charfudin Sacoor, Jorge Cano, Luis Izquierdo, Chetan E. Chitnis, Ross L. Coppel, Virander Chauhan, David Cavanagh, Sheetij Dutta, Evelina Angov, Deepak Gaur, Lisette van Lieshout, Bin Zhan, Jose Muñoz, Gemma Moncunill, Carlota Dobaño   +27 more
doaj   +1 more source

An Enteric Helminth Infection Protects Against an Allergic Response to Dietary Antigen [PDF]

The Journal of Immunology, 2002
Abstract Although helminths induce a polarized Th2 response they have been shown, in clinical studies, to confer protection against allergies. To elucidate the basis for this paradox, we have examined the influence of an enteric helminth infection on a model of food allergy.
Mohamed Elfatih H, Bashir, Peter, Andersen, Ivan J, Fuss, Hai Ning, Shi, Cathryn, Nagler-Anderson   +4 more
openaire   +2 more sources

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Plasmodium and soil-transmitted helminth co-infection : epidemiological interaction and impact among children living in endemic areas of Bagamoya, coastal region of Tanzania [PDF]

, 2015
Background: Parasitic infectious agents rarely occur in isolation and multiparasitism is a norm among population living in poor resource settings of developing countries.
Masoud, Nahya Salim
core   +1 more source

The effects of Ostertagia occidentalis somatic antigens on ovine TLR2 and TLR4 expression

Iranian Journal of Parasitology, 2015
Background: Recognition of helminth-derived pathogen associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs), including toll like recep­tors (TLRs) is the first step towards initiating anti–helminth immune re­sponses.
Hassan BORJI, Alireza HAGHPARAST, Nooshinmehr SOLEIMANI, Mohammad AZIZZADEH, Mohammad Hossein NAZEMSHIRAZI   +4 more
doaj  

Immunomodulatory Effects of Trichinella spiralis on Streptozotocin-Induced Diabetes in Mice: Prophylactic and Therapeutic Implications [PDF]

Delta Journal of Science
The growing burden of diabetes mellitus type 1 (T1-DM), stresses innovative therapeutic strategies. Helminth infections, such as Trichinella spiralis (T. spiralis), show powerful immunomodulatory effects that may mitigate autoimmune conditions.
Kareem Bakr, Nahla Radwan, Mohamed Mohamed, Mona Elwan   +3 more
doaj   +1 more source