Results 11 to 20 of about 9,987 (185)

Helminth species specific expansion and increased TNF-alpha production of non-classical monocytes during active tuberculosis.

PLoS Neglected Tropical Diseases, 2021
Both Mycobacterium tuberculosis infection and helminths may affect innate immune mechanisms such as differential effects on monocytes towards the non-classical and intermediate subsets that favor bacterial persistence.
Gezahegn Bewket, Amare Kiflie, Ebba Abate, Olle Stendahl, Thomas Schön, Robert Blomgran   +5 more
doaj   +1 more source

Pre-existing helminth infection impairs the efficacy of adjuvanted influenza vaccination in mice.

PLoS ONE, 2022
The world health organization estimates that more than a quarter of the human population is infected with parasitic worms that are called helminths. Many helminths suppress the immune system of their hosts to prolong their survival. This helminth-induced
Wiebke Hartmann, Marie-Luise Brunn, Nadine Stetter, Gülsah Gabriel, Minka Breloer   +4 more
doaj   +1 more source

Promising Technologies in the Field of Helminth Vaccines

Frontiers in Immunology, 2021
Helminths contribute a larger global burden of disease than both malaria and tuberculosis. These eukaryotes have caused human infections since before our earliest recorded history (i.e.: earlier than 1200 B.C. for Schistosoma spp.).
Dilhan J. Perera, Dilhan J. Perera, Momar Ndao, Momar Ndao, Momar Ndao, Momar Ndao   +5 more
doaj   +1 more source

How to train your myeloid cells: a way forward for helminth vaccines?

Frontiers in Immunology, 2023
Soil-transmitted helminths affect approximately 1.5 billion people worldwide. However, as no vaccine is currently available for humans, the current strategy for elimination as a public health problem relies on preventive chemotherapy.
Rory Doolan, Rory Doolan, Namitha Putananickal, Namitha Putananickal, Lucienne Tritten, Lucienne Tritten, Lucienne Tritten, Tiffany Bouchery, Tiffany Bouchery   +8 more
doaj   +1 more source

Responses to Malarial Antigens Are Altered in Helminth‐Infected Children [PDF]

The Journal of Infectious Diseases, 2009
Malaria and helminth infections often coincide in the same tropical regions. Studies of the consequences of helminth and malaria coinfection in humans have been few and are mainly epidemiological, with little information on cellular immune responses. In this study, we investigated the antimalarial immune responses of Ghanaian children living in a rural
Hartgers, F.C., Obeng, B.B., Kruize, Y.C., Dijkhuis, A., McCall, M.B.B., Sauerwein, R.W., Luty, A.J.F., Boakye, D.A., Yazdanbakhsh, M.   +8 more
openaire   +4 more sources

Effect of treating Schistosoma haematobium infection on Plasmodium falciparum-specific antibody responses

BMC Infectious Diseases, 2008
Background The overlapping geographical and socio-economic distribution of malaria and helminth infection has led to several studies investigating the immunological and pathological interactions of these parasites.
Mduluza T, Cavanagh DR, Magkrioti C, Reilly L, Mutapi F   +4 more
doaj   +1 more source

Helminth species-specific effects on IFN-γ producing T cells during active and latent tuberculosis.

PLoS Neglected Tropical Diseases, 2023
BackgroundInterferon-γ (IFN-γ) is a key cytokine inducing protective immune responses during tuberculosis (TB) infection. Helminth-induced immune responses may affect IFN-γ production by T cells, although its connection with disease severity and immune ...
Amare Kiflie, Gezahegn Bewket, Fitsumbrhan Tajebe, Ebba Abate, Thomas Schӧn, Robert Blomgran   +5 more
doaj   +1 more source

Immunoblotting Identification of Diagnostic Antigens of Paragonimus westermani Type 1 for the Detection of Human Pulmonary Paragonimiasis in North East India

Tropical Medicine and Infectious Disease, 2023
Human pulmonary paragonimiasis, an emerging concern in North East India, frequently masquerades as pulmonary tuberculosis due to clinical and radiological similarities, leading to diagnostic challenges.
Kangjam Rekha Devi, Archana Deka, Debdutta Mukherjee, Harpreet Kaur, Kanwar Narain   +4 more
doaj   +1 more source

Necator americanus and helminth co-infections: further down-modulation of hookworm-specific type 1 immune responses.

PLoS Neglected Tropical Diseases, 2011
BackgroundHelminth co-infection in humans is common in tropical regions of the world where transmission of soil-transmitted helminths such as Ascaris lumbricoides, Trichuris trichiura, and the hookworms Necator americanus and Ancylostoma duodenale as ...
Stefan Michael Geiger, Neal Douglas Edward Alexander, Ricardo Toshio Fujiwara, Simon Brooker, Bonnie Cundill, David Joseph Diemert, Rodrigo Correa-Oliveira, Jeffrey Michael Bethony   +7 more
doaj   +1 more source

Antigens of parasitic helminths in diagnosis, protection and pathology

Parasitology, 1989
SUMMARYA thorough study of parasitic helminth antigens is a pre-requisite for control programmes based on accurate immunochemical diagnosis, protection by vaccination and perhaps immune modulation to diminish pathological sequelae. Studies should be directed at the identification of those stage- or age-specific surface, secreted and somatic antigens ...
R M, Parkhouse, L J, Harrison
openaire   +2 more sources