Results 11 to 20 of about 195,323 (225)

Necator americanus and helminth co-infections: further down-modulation of hookworm-specific type 1 immune responses. [PDF]

PLoS Neglected Tropical Diseases, 2011
BackgroundHelminth co-infection in humans is common in tropical regions of the world where transmission of soil-transmitted helminths such as Ascaris lumbricoides, Trichuris trichiura, and the hookworms Necator americanus and Ancylostoma duodenale as ...
Stefan Michael Geiger, Neal Douglas Edward Alexander, Ricardo Toshio Fujiwara, Simon Brooker, Bonnie Cundill, David Joseph Diemert, Rodrigo Correa-Oliveira, Jeffrey Michael Bethony   +7 more
doaj   +2 more sources

Impact of Anthelminthic Treatment in Pregnancy and Childhood on Immunisations, Infections and Eczema in Childhood : A Randomised Controlled Trial [PDF]

, 2012
Helminth infections may modulate immune responses to unrelated pathogens and allergens; these effects may commence prenatally. We addressed the hypothesis that anthelminthic treatment in pregnancy and early childhood would improve responses to ...
Mpairwe, Harriet, Rutebarika, Diana, Kizindo, Robert, Apule, Barbara, Akurut, Hellen, Oduru, Gloria, Webb, Emily L., Elliott, Alison M., Kizza, Moses, Muwanga, Moses, Muhangi, Lawrence, Kihembo, Macklyn, Nampijja, Margaret, Tweyongere, Robert, Lule, Swaib A., Alcock, Katherine J., Kizito, Dennison, Ndibazza, Juliet, Mawa, Patrice A., Akello, Florence, Naniima, Peter   +20 more
core   +5 more sources

Helminth species specific expansion and increased TNF-alpha production of non-classical monocytes during active tuberculosis.

PLoS Neglected Tropical Diseases, 2021
Both Mycobacterium tuberculosis infection and helminths may affect innate immune mechanisms such as differential effects on monocytes towards the non-classical and intermediate subsets that favor bacterial persistence.
Gezahegn Bewket, Amare Kiflie, Ebba Abate, Olle Stendahl, Thomas Schön, Robert Blomgran   +5 more
doaj   +1 more source

Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis [PDF]

, 2009
Helminth immunology is a field which has changed beyond recognition in the past 30 years, transformed not only by new technologies from cDNA cloning to flow cytometry, but also conceptually as our definition of host immune pathways has matured.
R. M. MAIZELS, Maizels, R M
core   +1 more source

Soil-Transmitted Helminth Vaccines: Are We Getting Closer?

Frontiers in Immunology, 2020
Parasitic helminths infect over one-fourth of the human population resulting in significant morbidity, and in some cases, death in endemic countries.
Ayat Zawawi, Kathryn J. Else
doaj   +1 more source

Pre-existing helminth infection impairs the efficacy of adjuvanted influenza vaccination in mice.

PLoS ONE, 2022
The world health organization estimates that more than a quarter of the human population is infected with parasitic worms that are called helminths. Many helminths suppress the immune system of their hosts to prolong their survival. This helminth-induced
Wiebke Hartmann, Marie-Luise Brunn, Nadine Stetter, Gülsah Gabriel, Minka Breloer   +4 more
doaj   +1 more source

Promising Technologies in the Field of Helminth Vaccines

Frontiers in Immunology, 2021
Helminths contribute a larger global burden of disease than both malaria and tuberculosis. These eukaryotes have caused human infections since before our earliest recorded history (i.e.: earlier than 1200 B.C. for Schistosoma spp.).
Dilhan J. Perera, Dilhan J. Perera, Momar Ndao, Momar Ndao, Momar Ndao, Momar Ndao   +5 more
doaj   +1 more source

Responses to Malarial Antigens Are Altered in Helminth‐Infected Children [PDF]

The Journal of Infectious Diseases, 2009
Malaria and helminth infections often coincide in the same tropical regions. Studies of the consequences of helminth and malaria coinfection in humans have been few and are mainly epidemiological, with little information on cellular immune responses. In this study, we investigated the antimalarial immune responses of Ghanaian children living in a rural
Hartgers, F.C., Obeng, B.B., Kruize, Y.C., Dijkhuis, A., McCall, M.B.B., Sauerwein, R.W., Luty, A.J.F., Boakye, D.A., Yazdanbakhsh, M.   +8 more
openaire   +4 more sources

Comparison of schistosoma mansoni soluble cercarial antigens and soluble egg antigens for serodiagnosing schistosome infections [PDF]

, 2011
A Schistosoma mansoni cercarial antigen preparation (cercarial transformation fluid – SmCTF) was evaluated for detection of anti-schistosome antibodies in human sera in 4 collaborating laboratories.
Dawson, E., Smith, H., Ji, Minjun, Mike Doenhoff, Emily Dawson, Claire Alexander, Gilis, Henk, van Gool, T., Cara Aitken (135264), Grant Spence, Aitken, Cara, Aitken, C., Bailey, W., Cara Aitken, Minjun Ji (135275), Spence, G., Spence, Grant, Henk Gilis, Tom van Gool, Doenhoff, M., Claire Alex, Wendi Bailey, Mike Doenhoff (135259), Gilis, H., Huw Smith, Doenhoff, Mike, van Gool, Tom, Dawson, Emily, Smith, Huw, Tom van Gool (135295), Henk Gilis (135283), Claire Alexander (20985), Minjun Ji, Bailey, Wendi, Grant Spence (135288), Alexander, C., Ji, M., Huw Smith (135256), Wendi Bailey (135270), Emily Dawson (135279), Alexander, Claire   +40 more
core   +2 more sources

How to train your myeloid cells: a way forward for helminth vaccines?

Frontiers in Immunology, 2023
Soil-transmitted helminths affect approximately 1.5 billion people worldwide. However, as no vaccine is currently available for humans, the current strategy for elimination as a public health problem relies on preventive chemotherapy.
Rory Doolan, Rory Doolan, Namitha Putananickal, Namitha Putananickal, Lucienne Tritten, Lucienne Tritten, Lucienne Tritten, Tiffany Bouchery, Tiffany Bouchery   +8 more
doaj   +1 more source