Results 1 to 10 of about 741,967 (304)

The spleen: a hub connecting nervous and immune systems in cardiovascular and metabolic diseases [PDF]

, 2017
Metabolic disorders have been identified as major health problems affecting a large portion of the world population. In addition, obesity and insulin resistance are principal risk factors for the development of cardiovascular diseases.
Carnevale, Daniela, Lembo, Giuseppe, Lori, Andrea, Perrotta, Marialuisa   +3 more
core   +11 more sources

CD83 expressed by macrophages is an important immune checkpoint molecule for the resolution of inflammation

Frontiers in Immunology, 2023
Excessive macrophage (Mφ) activation results in chronic inflammatory responses or autoimmune diseases. Therefore, identification of novel immune checkpoints on Mφ, which contribute to resolution of inflammation, is crucial for the development of new ...
Katrin Peckert-Maier, Pia Langguth, Astrid Strack, Lena Stich, Petra Mühl-Zürbes, Christine Kuhnt, Christina Drassner, Elisabeth Zinser, Marius Wrage, Jochen Mattner, Alexander Steinkasserer, Dmytro Royzman, Andreas B. Wild   +12 more
doaj   +1 more source

Immune Priming: Mothering Males Modulate Immunity [PDF]

Current Biology, 2013
The transfer of immunity from mother to offspring is widespread in animals. The father's contribution to this is usually negligible. However, in a sex-role reversed pipefish where fathers do the mothering, fathers make an important immune priming contribution, too.
Keightley, M. Cristina, Wong, Bob B.M., Lieschke, Graham J.   +2 more
openaire   +2 more sources

Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages’ Function but Does Not Trigger the Adaptive T Cell Immune Response

Journal of Immunology Research, 2022
C-Type lectin receptor 5A (CLEC5A) is a spleen tyrosine kinase- (Syk-) coupled pattern recognition receptor expressed on myeloid cells and involved in the innate immune response to viral and bacterial infections.
Milena J. Tosiek, Kerstin Groesser, Anton Pekcec, Monika Zwirek, Gavuthami Murugesan, Eric Borges   +5 more
doaj   +1 more source

Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism

Frontiers in Immunology, 2023
Alterations in macrophage (Mφ) polarization, function, and metabolic signature can foster development of chronic diseases, such as autoimmunity or fibrotic tissue remodeling. Thus, identification of novel therapeutic agents that modulate human Mφ biology
Katrin Peckert-Maier, Andreas B. Wild, Laura Sprißler, Maximilian Fuchs, Philipp Beck, Jean-Philippe Auger, Pia Sinner, Astrid Strack, Petra Mühl-Zürbes, Ntilek Ramadan, Meik Kunz, Meik Kunz, Gerhard Krönke, Lena Stich, Alexander Steinkasserer, Dmytro Royzman   +15 more
doaj   +1 more source

How mucosal epithelia deal with stress: Role of NKG2D/NKG2D ligands during inflammation [PDF]

, 2017
Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions.
Alessandra Soriani, Angela Santoni, Angela Santoni, Cristina Cerboni, Fabrizio Antonangeli, Giuseppe Sciumè   +5 more
core   +10 more sources

HSV-1 Modulates IL-6 Receptor Expression on Human Dendritic Cells

Frontiers in Immunology, 2020
Dendritic cells (DCs) are the guardians of the immune system since they are located in the majority of peripheral tissues. In addition, they are crucial for the induction of an effective immune response based on their unique capacity to stimulate naive T
Alexandra Birzer, Adalbert Krawczyk, Adalbert Krawczyk, Christina Draßner, Christine Kuhnt, Petra Mühl-Zürbes, Christiane Silke Heilingloh, Christiane Silke Heilingloh, Alexander Steinkasserer, Linda Popella   +9 more
doaj   +1 more source

Microalgae—Sustainable Source for Alternative Proteins and Functional Ingredients Promoting Gut and Liver Health

Global Challenges, 2023
Dietary proteins derived from animal sources, although containing well‐balanced profiles of essential amino acids, have considerable environmental and adverse health effects associated with the intake of some animal protein‐based products.
Yahav Eilam, Hamdan Khattib, Noam Pintel, Dorit Avni   +3 more
doaj   +1 more source

The CD83 Molecule – An Important Immune Checkpoint

Frontiers in Immunology, 2020
The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils.
Linda Grosche, Ilka Knippertz, Christina König, Dmytro Royzman, Andreas B. Wild, Elisabeth Zinser, Heinrich Sticht, Yves A. Muller, Alexander Steinkasserer, Matthias Lechmann   +9 more
doaj   +1 more source

Herpes Simplex Virus Type-2 Paralyzes the Function of Monocyte-Derived Dendritic Cells

Viruses, 2020
Herpes simplex viruses not only infect a variety of different cell types, including dendritic cells (DCs), but also modulate important cellular functions in benefit of the virus. Given the relevance of directed immune cell migration during the initiation
Linda Grosche, Petra Mühl-Zürbes, Barbara Ciblis, Adalbert Krawczyk, Christine Kuhnt, Lisa Kamm, Alexander Steinkasserer, Christiane Silke Heilingloh   +7 more
doaj   +1 more source