Results 11 to 20 of about 741,967 (304)

Distinct immune stimulatory effects of anti-human VISTA antibodies are determined by Fc-receptor interaction

Frontiers in Immunology, 2022
VISTA (PD-1H) is an immune regulatory molecule considered part of the next wave of immuno-oncology targets. VISTA is an immunoglobulin (Ig) superfamily cell surface molecule mainly expressed on myeloid cells, and to some extent on NK cells and T cells ...
Sven Mostböck, Helen Haixia Wu, Timothy Fenn, Bettina Riegler, Susanne Strahlhofer, Yining Huang, Gale Hansen, Rachel Kroe-Barrett, Iñigo Tirapu, Anne B. Vogt   +9 more
doaj   +1 more source

Opioid Receptors in Immune and Glial Cells-Implications for Pain Control [PDF]

, 2020
Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Celik, Melih Ö., Machelska, Halina
core   +1 more source

Immune Modulation in Xenotransplantation [PDF]

Archivum Immunologiae et Therapiae Experimentalis, 2014
The use of animals as donors of tissues and organs for xenotransplantations may help in meeting the increasing demand for organs for human transplantations. Clinical studies indicate that the domestic pig best satisfies the criteria of organ suitability for xenotransplantation.
Boksa, Magdalena, Zeyland, Joanna, Słomski, Ryszard, Lipiński, Daniel   +3 more
openaire   +2 more sources

Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis

Nature Communications, 2023
Microglial activation during neuroinflammation is crucial for coordinating the immune response against neuronal tissue, and the initial response of microglia determines the severity of neuro-inflammatory diseases.
Pia Sinner, Katrin Peckert-Maier, Hashem Mohammadian, Christine Kuhnt, Christina Draßner, Vasiliki Panagiotakopoulou, Simon Rauber, Mathias Linnerbauer, Zhana Haimon, Dmytro Royzman, Deborah Kronenberg-Versteeg, Andreas Ramming, Alexander Steinkasserer, Andreas B. Wild   +13 more
doaj   +1 more source

Mass Spectrometric Characterization of HSV-1 L-Particles From Human Dendritic Cells and BHK21 Cells and Analysis of Their Functional Role

Frontiers in Microbiology, 2020
Herpes simplex virus type 1 (HSV-1) is a very common human pathogenic virus among the world’s population. The lytic replication cycle of HSV-1 is, amongst others, characterized by a tripartite viral gene expression cascade, the assembly of nucleocapsids ...
Alexandra Birzer, Max Edmund Kraner, Christiane Silke Heilingloh, Petra Mühl-Zürbes, Jörg Hofmann, Alexander Steinkasserer, Linda Popella   +6 more
doaj   +1 more source

LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager

Frontiers in Immunology, 2022
Colorectal cancer (CRC) is one of the most common cancers worldwide and demands more effective treatments. We sought to identify tumor selective CRC antigens and their therapeutic potential for cytotoxic T-cell targeting by transcriptomic and ...
Leticia Corrales, Susanne Hipp, Susanne Hipp, Katharina Martin, Nicolas Sabarth, Iñigo Tirapu, Klaus Fuchs, Barbara Thaler, Christian Walterskirchen, Kathrin Bauer, Markus Fabits, Michael Bergmann, Carina Binder, Paolo ML. Chetta, Anne B. Vogt, Paul J. Adam   +15 more
doaj   +1 more source

Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics

iScience, 2023
Summary: Small molecule IAP antagonists - SMAC mimetics (SM) - are being developed as an anticancer therapy. SM therapy was demonstrated not only to sensitize tumor cells to TNFα-mediated cell death but also to exert immunostimulatory properties.
Catarina Pinto, Ksenija Slavic-Obradovic, Daniela Fürweger, Barbara Thaler, Abdallah Souabni, Sebastian Carotta, Martin Aichinger, Ulrich Reiser, Maria Antonietta Impagnatiello, Iñigo Tirapu   +9 more
doaj   +1 more source

Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells

Frontiers in Immunology, 2019
The CD83 is a type I membrane protein and part of the immunoglobulin superfamily of receptors. CD83 is involved in the regulation of antigen presentation and dendritic cell dependent allogeneic T cell proliferation.
Elisabeth Zinser, Ronald Naumann, Andreas B. Wild, Julia Michalski, Andrea Deinzer, Lena Stich, Christine Kuhnt, Alexander Steinkasserer, Ilka Knippertz   +8 more
doaj   +1 more source

Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

eLife, 2023
Cytotoxic CD8 +T lymphocytes (CTLs) are key players of adaptive anti-tumor immunity based on their ability to specifically recognize and destroy tumor cells. Many cancer immunotherapies rely on unleashing CTL function.
Ann-Kathrin Herzfeldt, Marta Puig Gamez, Eva Martin, Lukasz Miloslaw Boryn, Praveen Baskaran, Heinrich J Huber, Michael Schuler, John E Park, Lee Kim Swee   +8 more
doaj   +1 more source

The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis

Frontiers in Immunology, 2022
Here we show that soluble CD83 induces the resolution of inflammation in an antigen-induced arthritis (AIA) model. Joint swelling and the arthritis-related expression levels of IL-1β, IL-6, RANKL, MMP9, and OC-Stamp were strongly reduced, while Foxp3 was
Dmytro Royzman, Darja Andreev, Lena Stich, Katrin Peckert-Maier, Andreas B. Wild, Elisabeth Zinser, Petra Mühl-Zürbes, Evan Jones, Susanne Adam, Silke Frey, Maximilian Fuchs, Meik Kunz, Meik Kunz, Tobias Bäuerle, Lisa Nagel, Georg Schett, Aline Bozec, Alexander Steinkasserer   +17 more
doaj   +1 more source