Results 51 to 60 of about 34,106 (197)

NTAQ1 Promotes Hepatocellular Carcinoma Growth by Facilitating the Protein Degradation of the Tumor Suppressor PRDM2

Cancer Science, EarlyView.
Copy number variation analysis in The Cancer Genome Atlas identified NTAQ1 as a potential driver of HCC progression. NTAQ1 accelerates tumor growth by promoting the degradation of the tumor suppressor protein PRDM2, thereby impairing DNA repair and suppressing apoptosis. These findings indicate that NTAQ1 could be a valuable target for the treatment of
Tomohiko Ikehara, Hajime Otsu, Taro Tobo, Kiyotaka Hosoda, Tadashi Abe, Masahiro Hashimoto, Yusuke Nakano, Katsushi Dairaku, Yuya Ono, Yuki Miyata, Chihiro Matsumoto, Takanari Tatsumi, Satoshi Higuchi, Takashi Ofuchi, Akinori Tsujimoto, Yuki Ando, Qingjiang Hu, Yusuke Yonemura, Akira Shimizu, Takaaki Masuda, Yuji Soejima, Koshi Mimori   +21 more
wiley   +1 more source

Isolation of ESBL-producing gram-negative bacteria and in silico inhibition of ESBLs by flavonoids

Journal of Taibah University Medical Sciences, 2016
AbstractObjectiveTo evaluate nosocomial accounts of 426 extended spectrum β-lactamase (ESBL)-producing strains from 705 isolates of 9 pathogenic gram-negative bacteria in vitro. We analysed the genetic divergence of ESBLs by constructing a phylogenetic tree and modelled flavonoid inhibition of ESBLs with in silico molecular docking to determine ...
Swain, Shasank S., Padhy, Rabindra N.
openaire   +1 more source

Risk Factors of Blood Culture Positivity and Mortality in Bloodstream Infections: A Population‐Based Study of Patients With B‐Cell Malignancies

European Journal of Haematology, EarlyView.
ABSTRACT Background Bloodstream infections remain a major cause of mortality among cancer patients. Pathogen surveillance and risk stratification tools are key to improved management. This study describes trends in causative pathogens and explores risk factors for positive blood cultures (PBCs) and post‐infection mortality in cancer patients.
Mathias Holmsgaard Eskesen, Alexander Djupnes Fuglkjær, Tarec Christoffer El‐Galaly, Paw Jensen, Izabela Ewa Nielsen, Laurids Østergaard Poulsen, Mikkel Runason Simonsen, Kirstine Kobberøe Søgaard   +7 more
wiley   +1 more source

Can Artificial Intelligence Be Utilised to Develop Point‐of‐Care Endodontic Microbiological Technologies?

International Endodontic Journal, EarlyView.
ABSTRACT Background Primary or persistent endodontic disease is caused by microbial biofilms that irritate the pulp and periapical tissues. Extensive microbiological analyses of these biofilms and their constituent pathogens have revealed their diversity and complexity.
Ashraf F. Fouad
wiley   +1 more source

Multi-Drug Resistance Profile, Prevalence of Extended-Spectrum Beta-Lactamase and Carbapenemase-Producing Gram Negative Bacilli Among Admitted Patients After Surgery with Suspected of Surgical Site Nosocomial Infection North East Ethiopia

Infection and Drug Resistance, 2022
Mihret Tilahun Department of Medical Laboratory Sciences, College of Medicine and Health Science, Wollo University, Dessie, EthiopiaCorrespondence: Mihret Tilahun, Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wollo ...
Tilahun M
doaj  

ESBL-Positive Enterobacteria Isolates in Drinking Water

Emerging Infectious Diseases, 2012
To the Editor: Extended-spectrum β-lactamase (ESBL)–producing members of the family Enterobacteriaceae (enterobacteria) are a worldwide problem (1), but little data are available from central Africa (2). In recent years, ESBL-producing Enterobacteriaceae isolates have shifted from the hospital to the community and the environment (1).
De Boeck, H., Miwanda, B., Lunguya Metila, O., Muyembe Tamfum, J. J., Stobberingh, E.E., Glupczynski, Y., Jacobs, J.A.   +6 more
openaire   +4 more sources

The effects of far‐UVC irradiation on the presence and concentration of ESKAPEE pathogens on hospital surfaces: Study protocol for a multi‐site, double‐blinded randomized controlled trial in La Paz, Bolivia

Photochemistry and Photobiology, EarlyView.
The protocol of a multi‐site, double‐blinded, clustered randomized controlled trial (cRCT) with a binary outcome of the presence of viable presumptive ESKAPEE pathogens on surfaces in and around hospital sinks is to be implemented in two Bolivian hospitals.
Lindsay B. Saber, Melani Rojas, Darcy M. Anderson, Deverick J. Anderson, Holger Claus, Ryan Cronk, Karl G. Linden, Megan E. J. Lott, Lewis J. Radonovich Jr., Bobby G. Warren, Richard D. Williamson, Richard L. Vincent, Sergio Gutiérrez‐Cortez, Carla Calderón Toledo, Joe Brown   +14 more
wiley   +1 more source

Early Onset Bacteremia in Kidney Transplant Recipients in the Current Era

Transplant Infectious Disease, EarlyView.
ABSTRACT Background Bloodstream infection (BSI) after kidney transplantation increases the risk of graft loss and mortality. We aimed to identify contemporary risk factors and outcomes of early BSI (eBSI) at our transplant center. Methods We conducted a retrospective chart review of adult kidney transplant recipients (KTRs) from 2019 to 2023.
Lana Hasan, Nabin K. Shrestha, Mathew Duck, Joshua Augustine, Richard Fatica, Alvin Wee, Christine E. Koval   +6 more
wiley   +1 more source

Perbandingan kecepatan pertumbuhan Escherichia coli non ESBL dengan Escherichia coli ESBL

Jurnal Kedokteran Syiah Kuala, 2020
Abstrak. Penelitian ini bertujuan untuk mengidentifikasi perbedaan kecepatan pertumbuhan antara kelompok bakteri Escherichia coli NON ESBL dengan kelompok Escherichia coli ESBL. Jenis dan rancangan penelitian ini adalah penelitian eksperimental. Besar sampel sebanyak 13 isolat bakteri Escherihcia coli. Teknik sampling yang digunakan non random sampling.
Branandito Putra, Linda Dewanti, Eddy Bagus Wasito   +2 more
openaire   +2 more sources

Donor Dilemma: A National Simulation‐Based Case Curriculum for Teaching Donor Call Decision‐Making in Infectious Diseases Trainees

Transplant Infectious Disease, EarlyView.
An asynchronous donor‐call case‐based progressive disclosure curriculum was feasible and valued across diverse ID and TID training programs. ID and TID trainees reported improved confidence in their clinical reasoning and ability to evaluate donor‐suitability, supporting this educational approach to address a training gap.
Robert Sean Tyler, Rachel B. Colven, Alexandra G. Mills, Drew W. Charles, Ruth O. Adekunle, Divisha Sharma, Yosra Alkabab, Scott R. Curry, Ricardo M. La Hoz, Courtney E. Harris   +9 more
wiley   +1 more source