Results 81 to 90 of about 804,660 (312)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Wheels of Escape: Seeking Nature, Well-Being and Gratitude on the Road [PDF]

Journal of Tourism, Sustainability and Well-being
This study examines individuals’ motivations for escaping and seeking in the context of nature-oriented sightseeing travel, with a specific focus on bus travel as the primary mode of transportation.
Özgür Koyun, Gökçe Yüksek
doaj   +1 more source

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Nature, 2019
Chimeric antigen receptors (CARs) are synthetic antigen receptors that reprogram T cell specificity, function and persistence1. Patient-derived CAR T cells have demonstrated remarkable efficacy against a range of B-cell malignancies1–3, and the results ...
Mohamad Hamieh, Anton Dobrin, Annalisa Cabriolu, Sjoukje J. C. van der Stegen, Theodoros Giavridis, J. Mansilla-Soto, Justin Eyquem, Zeguo Zhao, Benjamin Whitlock, Matthew M. Miele, Zhuoning Li, K. Cunanan, M. Huse, R. Hendrickson, Xiuyan Wang, I. Rivière, M. Sadelain   +16 more
semanticscholar   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Phlebotomine sand flies (Diptera, Psychodidae) of the world

Parasites & Vectors
Background Checklists of zoological groups are useful to document species names in a specific area or even worldwide. They serve for various purposes, including ecological studies, conservation reports, policy and decision-making, and species ...
Eunice Aparecida Bianchi Galati, Andrey José de Andrade, Farzana Perveen, Mathieu Loyer, Khamsing Vongphayloth, Fano José Randrianambinintsoa, Jorian Prudhomme, Nil Rahola, Mohammad Akhoundi, Paloma Helena Fernandes Shimabukuro, Jérôme Depaquit   +10 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

β-catenin activation promotes immune escape and resistance to anti-PD-1 therapy in hepatocellular carcinoma

Cancer Discovery, 2019
PD-1 immune checkpoint inhibitors have produced encouraging results in hepatocellular carcinoma (HCC) patients. However, what determines resistance to anti-PD-1 therapies is unclear.
M. Ruiz de Galarreta, Erin R. Bresnahan, Pedro Molina-Sánchez, K. Lindblad, B. Maier, D. Sia, M. Puigvehí, Verónica Miguela, M. Casanova-Acebes, Maxime Dhainaut, C. Villacorta-Martin, A. Singhi, A. Moghe, J. von Felden, Lauren Tal Grinspan, Shuang Wang, A. Kamphorst, S. Monga, Brian D. Brown, A. Villanueva, J. Llovet, M. Merad, A. Lujambio   +22 more
semanticscholar   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Tumor Antigen Escape from CAR T-cell Therapy.

Cancer Discovery, 2018
Emerging data from chimeric antigen receptor (CAR) T-cell trials in B-cell malignancies demonstrate that a common mechanism of resistance to this novel class of therapeutics is the emergence of tumors with loss or downregulation of the target antigen ...
R. Majzner, C. Mackall
semanticscholar   +1 more source