Results 61 to 70 of about 804,660 (312)
BCL-XL directly modulates RAS signalling to favour cancer cell stemness
Nature Communications, 2017 BCL-XL provides a survival advantage to cancer cells even in the absence of apoptotic pressures. In this study, the authors show that BCL-XL interacts with RAS in a BH4-dependent manner and regulates RAS-mediated activation of pathways involved in the ...
Sophie de Carné Trécesson +15 more
doaj +1 more source
RNA Viruses and RNAi: Quasispecies Implications for Viral Escape
Viruses, 2015 Due to high mutation rates, populations of RNA viruses exist as a collection of closely related mutants known as a quasispecies. A consequence of error-prone replication is the potential for rapid adaptation of RNA viruses when a selective pressure is ...
John B. Presloid, Isabel S. Novella
doaj +1 more source
Prospective mapping of viral mutations that escape antibodies used to treat COVID-19
Science, 2021 Mapping antibody escape in SARS-CoV-2 Several antibodies are in use or under development as therapies to treat COVID-19. As new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerge, it is important to predict whether they will ...
Tyler N. Starr +7 more
semanticscholar +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Variation in Predator Recognition Across Three Species of Jumping Spiders (Salticidae) [PDF]
Animal Behavior and CognitionThe ability to recognize threats and to respond in a timely and appropriate manner carries significant benefits. Depending on the recognition task, this can be cognitively demanding.
Janka Plate, Daniela C. Rößler
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
G2019S selective LRRK2 kinase inhibitor abrogates mitochondrial DNA damage
npj Parkinson's DiseasePathogenic mutations in LRRK2 cause Parkinson’s disease (PD). The G2019S variant is the most common, which results in abnormally high kinase activity. Compounds that target LRRK2 kinase activity are currently being developed and tested in clinical trials.
Nicholas Pena +8 more
doaj +1 more source
European Journal of Entomology, 2018 We investigated the effect of the feeding behaviour of young larvae of Pieris rapae crucivora Boisduval (Pieridae) on parasitism by the parasitoid wasp, Cotesia glomerata (L.) (Braconidae).
Aya NAKAYAMA, Keiji NAKAMURA, Jun TAGAWA
doaj +1 more source
Typographical Artifices in Nicola Barker’s H(A)PPY
Ars & Humanitas, 2022 In Nicola Barker’s novel H(A)PPY the individual’s struggle to resist and escape from a virtualized, monitored and uniform world is masterfully reflected typographically.
Mihaela Culea, Andreia Irina Suciu
doaj +1 more source