Results 51 to 60 of about 804,660 (312)
, 2023 In Sinai trafficking Eritreans made up the majority of victims. But what makes them so vulnerable to human trafficking for ransom? The interviews for this chapter found a number of reasons, including the fact that Eritrea is a ‘black hole’ in the digital landscape – which means that Eritreans are uninformed and dependent on smugglers and traffickers ...
Smits, Klara, Wirtz, Morgane
openaire +2 more sources
Endosomal escape: A bottleneck for LNP-mediated therapeutics
Proceedings of the National Academy of Sciences of the United States of AmericaLipid nanoparticles (LNPs) have recently emerged as a powerful and versatile clinically approved platform for nucleic acid delivery, specifically for mRNA vaccines.
Sushmita Chatterjee +3 more
semanticscholar +1 more source
SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape
Cell Host and Microbe, 2022 Summary Characterizing SARS-CoV-2 evolution in specific geographies may help predict properties of the variants that come from these regions. We mapped neutralization of a SARS-CoV-2 strain that evolved over 6 months from ancestral virus in a person with
S. Cele +27 more
semanticscholar +1 more source
Cases and Efforts to Escape from the Soviet Union by Lithuanians
Genocidas ir Rezistencija, 2001 The work depicts the efforts of Lithuanians to escape from the Soviet Union during the 1970s. Just in 1970 there were three attempts to run away from the USSR. That year the father and the son Brazinskai hijacked a plane and managed to escape to Turkey.
Agnė Fabijonavičiūtė
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Within-Epitope Interactions Can Bias CTL Escape Estimation in Early HIV Infection
Frontiers in Immunology, 2017 As human immunodeficiency virus (HIV) begins to replicate within hosts, immune responses are elicited against it. Escape mutations in viral epitopes—immunogenic peptide parts presented on the surface of infected cells—allow HIV to partially evade these ...
Victor Garcia, Marcus W. Feldman
doaj +1 more source
Digital Escape Rooms as Innovative Pedagogical Tools in Education: A Systematic Literature Review
Sustainability, 2021 This paper aims to present a systematic literature review on state-of-the-art Educational Escape Rooms (EERs) with the use of digital technologies. More specifically, the focus of the study is to present the current developments and trends concerning ...
A. Makri, D. Vlachopoulos, R. Martina
semanticscholar +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Wellcome Open ResearchBackground Efforts to estimate the global burden of antimicrobial resistance (AMR) have highlighted gaps in existing surveillance systems. Data gathered from hospital networks globally by pharmaceutical industries to monitor antibiotic efficacy in ...
Aleksandra Kovacevic +3 more
doaj +1 more source