Results 31 to 40 of about 804,660 (312)

Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

bioRxiv, 2020
Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed as therapeutics and make a major contribution to the neutralizing antibody response elicited by infection.
Allison J. Greaney, Tyler N. Starr, P. Gilchuk, Seth J. Zost, E. Binshtein, Andrea N. Loes, Sarah K. Hilton, J. Huddleston, Rachel T. Eguia, K. H. Crawford, A. Dingens, Rachel S. Nargi, Rachel E. Sutton, Naveenchandra Suryadevara, Paul W. Rothlauf, Zhuoming Liu, S. Whelan, R. Carnahan, J. Crowe, J. Bloom   +19 more
semanticscholar   +1 more source

The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron

Emerging Microbes and Infections, 2021
The emergence of Omicron/BA.1 has brought new challenges to fight against SARS-CoV-2. A large number of mutations in the Spike protein suggest that its susceptibility to immune protection elicited by the existing COVID-19 infection and vaccines may be ...
Li Zhang, Qian-qian Li, Zi-teng Liang, Taojing Li, Shuo Liu, Qianqian Cui, J. Nie, Qian Wu, X. Qu, Weijing Huang, Youchun Wang   +10 more
semanticscholar   +1 more source

Escaping a Polygon

CoRR, 2020
Suppose an escaping player ("human") moves continuously at maximum speed $1$ in the interior of a region, while a pursuing player ("zombie") moves continuously at maximum speed $r$ outside the region. For what $r$ can the first player escape the region, that is, reach the boundary a positive distance away from the pursuing player, assuming optimal play
Zachary Abel, Hugo A. Akitaya, Erik D. Demaine, Martin L. Demaine, Adam Hesterberg, Jason S. Ku, Jayson Lynch   +6 more
openaire   +2 more sources

SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection

medRxiv, 2021
The emergence of the Omicron variant (1) of SARS-CoV-2 in November 2021 in South Africa has raised concerns that, based on the large number of mutations in the spike protein and elsewhere on the virus (https://covdb.stanford.edu/page/mutation-viewer ...
S. Cele, Laurelle Jackson, K. Khan, D. Khoury, T. Moyo-Gwete, H. Tegally, C. Scheepers, D. Amoako, F. Karim, M. Bernstein, G. Lustig, Derseree Archary, Muneerah Smith, Y. Ganga, Z. Jule, K. Reedoy, D. Cromer, J. E. San, Shi-Hsia Hwa, J. Giandhari, J. Blackburn, B. Gosnell, S. Karim, W. Hanekom, A. von Gottberg, J. Bhiman, R. Lessells, M. S. Moosa, M. Davenport, Túlio de Oliveira, P. Moore, A. Sigal   +31 more
semanticscholar   +1 more source

Escaping the Shadow

Voices in Bioethics, 2022
Photo by Karl Raymund Catabas on Unsplash  “After Buddha was dead, they still showed his shadow in a cave for centuries – a tremendous, gruesome shadow. God is dead; but given the way people are, there may still for millennia be caves in which they show his shadow.
openaire   +3 more sources

Ways of escape [PDF]

The Lancet Psychiatry, 2016
This is the author accepted manuscript. The final version is available from Elsevier: Lancet via the DOI in this record.
McKay, K, Boyle, C
openaire   +3 more sources

Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

Nature, 2021
SARS-CoV-2 variants of concern (VOC) have arisen independently at multiple locations1,2 and may reduce the efficacy of current vaccines that target the spike glycoprotein of SARS-CoV-23.
S. Cele, I. Gazy, Laurelle Jackson, Shi-Hsia Hwa, H. Tegally, G. Lustig, J. Giandhari, S. Pillay, E. Wilkinson, Y. Naidoo, F. Karim, Y. Ganga, K. Khan, M. Bernstein, A. Balazs, B. Gosnell, W. Hanekom, M. Moosa, Shareef Luiz Carlos Junior Arghavan Mushal Jinal N. Mary-A Abrahams Alcantara Alisoltani-Dehkordi Allam Bhima, S. Abrahams, L. Alcântara, A. Alisoltani-Dehkordi, Mushal Allam, J. Bhiman, Mary-Ann Davies, D. Doolabh, S. Engelbrecht, V. Fonseca, M. Giovanetti, A. Glass, Adam Godzik, D. Goedhals, D. Hardie, M. Hsiao, A. Iranzadeh, A. Ismail, S. Korsman, S. L. K. Pond, O. Laguda-Akingba, José Lourenço, G. Marais, Darren P. Martin, C. Maslo, K. Mlisana, T. Mohale, N. Msomi, I. Mudau, Francesco Petruccione, W. Preiser, E. J. San, B. Sewell, L. Tyers, G. V. van Zyl, A. von Gottberg, S. Walaza, S. Weaver, C. K. Wibmer, C. Williamson, Denis York, Moherndran Kaylesh J. Philip Sashin Guy Rohen Kobus Prakash T Archary Dullabh Goulder Harilall Harling Harrichan, M. Archary, Kaylesh J Dullabh, P. Goulder, Sashin Harilall, G. Harling, Rohen Harrichandparsad, K. Herbst, P. Jeena, T. Khoza, N. Klein, H. Kløverpris, A. Leslie, R. Madansein, Mohlopheni J. Marakalala, M. Mazibuko, M. Moshabela, N. Mthabela, K. Naidoo, Z. Ndhlovu, T. Ndung’u, K. Nyamande, N. Padayatchi, Vinod B Patel, Dirhona Ramjit, H. Rodel, T. Smit, A. Steyn, E. Wong, R. Lessells, Túlio de Oliveira, A. Sigal   +90 more
semanticscholar   +1 more source

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

Science, 2021
Eluding detection Influenza viruses evade immunity initiated by previous infection, which explains recurrent influenza pandemics. Unlike the error-prone RNA-dependent RNA polymerase of influenza, severe acute respiratory syndrome coronavirus 2 (SARS-CoV ...
K. R. McCarthy, L. Rennick, Sham Nambulli, Lindsey R. Robinson-McCarthy, W. Bain, G. Haidar, W. Duprex   +6 more
semanticscholar   +1 more source

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

Molecular Cancer, 2019
Tumor immune escape is an important strategy of tumor survival. There are many mechanisms of tumor immune escape, including immunosuppression, which has become a research hotspot in recent years. The programmed death ligand-1/programmed death-1 (PD-L1/PD-
Xianjie Jiang, Jie Wang, Xiangying Deng, F. Xiong, Junshang Ge, Bo Xiang, Xu Wu, Jian Ma, Ming Zhou, Xiaoling Li, Yong Li, Gui-yuan Li, W. Xiong, Can Guo, Zhaoyang Zeng   +14 more
semanticscholar   +1 more source

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

bioRxiv, 2020
Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against SARS-CoV-2.
Y. Weisblum, F. Schmidt, Fengwen Zhang, Justin DaSilva, D. Poston, Julio C. C. Lorenzi, Frauke Muecksch, Magda Rutkowska, H. Hoffmann, E. Michailidis, C. Gaebler, Marianna Agudelo, A. Cho, Zijun Wang, A. Gazumyan, M. Cipolla, Larry L. Luchsinger, C. Hillyer, M. Caskey, D. Robbiani, C. Rice, M. Nussenzweig, T. Hatziioannou, P. Bieniasz   +23 more
semanticscholar   +1 more source