Results 41 to 50 of about 4,578 (289)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Dynamic Current Routing in Conductive Liquid Crystal Elastomers for Complex Deformation Actuators

open access: yesAdvanced Materials Technologies, EarlyView.
This work introduces a novel actuation control strategy in which electrical stimulation generates localized Joule heating in conductive liquid crystal elastomer (LCE) surfaces, enabling complex 3D deformations from a single homogeneous surface without preprogramming.
Gloria PouWai Lei   +2 more
wiley   +1 more source

Giant african snail, Achatina fulica (Férussac, 1821): an environmental and public health problem in the northwestern of Paraná State, Brazil

open access: yesActa Scientiarum: Biological Sciences, 2017
  Achatina fulica, known as Giant African Snail (GAS), was introduced in Brazil as a substitute for the European escargot, Helix aspersa maxima. However, its cultivation was abandoned and the mollusk became an invasive species, found throughout Brazil ...
Márcia Aparecida Andreazzi   +5 more
doaj   +1 more source

Strong‐Magnetic Flexible Composites for Magnetically Responsive Soft Robots

open access: yesAdvanced Robotics Research, EarlyView.
This perspective provides an overview of the performance mechanisms, preparation methods, and applications of strong magnetic flexible composite materials in soft actuators (such as gripping, movement, and sensing), and further explores current opportunities and challenges.
Wenwen Li   +4 more
wiley   +1 more source

Metabologenomic Hallmark‐Based Discovery of Bacterial Thioamides as a New Lead against Drug‐Resistant Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du   +18 more
wiley   +1 more source

Escargot Restricts Niche Cell to Stem Cell Conversion in the Drosophila Testis

open access: yesCell Reports, 2014
Stem cells reside within specialized microenvironments, or niches, that control many aspects of stem cell behavior. Somatic hub cells in the Drosophila testis regulate the behavior of cyst stem cells (CySCs) and germline stem cells (GSCs) and are a ...
Justin Voog   +9 more
doaj   +1 more source

Spartan Daily, August 28, 1985 [PDF]

open access: yes, 1985
Volume 85, Issue 2https://scholarworks.sjsu.edu/spartandaily/7323/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

open access: yesAdvanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu   +18 more
wiley   +1 more source

Transcription Factor Antagonism Controls Enteroendocrine Cell Specification from Intestinal Stem Cells

open access: yesScientific Reports, 2017
The balanced maintenance and differentiation of local stem cells is required for Homeostatic renewal of tissues. In the Drosophila midgut, the transcription factor Escargot (Esg) maintains undifferentiated states in intestinal stem cells, whereas the ...
Yumei Li   +5 more
doaj   +1 more source

BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila. [PDF]

open access: yesPLoS ONE, 2015
During tumorigenesis, pathways that promote the epithelial-to-mesenchymal transition (EMT) can both facilitate metastasis and endow tumor cells with cancer stem cell properties.
Karen Doggett   +6 more
doaj   +1 more source

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