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BMC Geriatrics, 2011 Background Escitalopram has shown efficacy and tolerability in the prevention of relapse in elderly patients with major depressive disorder (MDD). This post-hoc analysis compared time to relapse for young-old patients (n = 197) to that for old-old ...
Katona Cornelius +3 more
doaj +5 more sources
A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. [PDF]
, 2020 Predicting antidepressant response has been a clinical challenge for mood disorder. Although several genome-wide association studies have suggested a number of genetic variants to be associated with antidepressant response, the sample sizes are small and
Aitchison, Katherine J +14 more
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BMC Psychiatry, 2020 Background Previous studies have shown escitalopram is related to sleep quality. However, effects of escitalopram on dynamics of electroencephalogram (EEG) features especially during different sleep stages have not been reported.
Li Wu +6 more
doaj +1 more source
A survey of Top 200 Drugs—Inconsistent Practice of Drug Strength Expression for Drugs Containing Salt Forms [PDF]
, 2012 Many ionizable drugs are developed and marketed as salt forms. However, there are no clear US regulatory guidelines on drug strength labeling for salts. The strengths of some drugs are expressed as salts and some as free acids/bases.
Prohotsky, Daniel, Zhao, Fang
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Antidepressants versus placebo for depression in primary care [PDF]
, 2009 Background Concern has been expressed about the relevance of secondary care studies to primary care patients specifically about the effectiveness of antidepressant medication.
Arroll, Bruce +7 more
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PCN Reports, 2023 Background Jitteriness/anxiety syndrome is a recognized adverse effect observed during the initiation or change of dose in antidepressant treatment. Managing patients who develop this syndrome remains a challenge.
Kaoru Arai +3 more
doaj +1 more source
A meta-analysis of pharmacotherapy for social anxiety disorder: an examination of efficacy, moderators, and mediators [PDF]
, 2017 INTRODUCTION: Social anxiety disorder (SAD) is among the most prevalent mental disorders, associated with impaired functioning and poor quality of life. Pharmacotherapy is the most widely utilized treatment option.
Borenstein M +8 more
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Efficacy of new-generation antidepressants assessed with the Montgomery-Asberg depression rating scale, the gold standard clinician rating scale : a meta-analysis of randomised placebo-controlled trials [PDF]
, 2020 It has been claimed that efficacy estimates based on the Hamilton Depression Rating-Scale (HDRS) underestimate antidepressants true treatment effects due to the instrument's poor psychometric properties.
Hengartner, Michael Pascal +3 more
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Frontiers in Psychiatry, 2022 IntroductionA titration within a certain therapeutic reference range presupposes a relationship between the blood concentration and the therapeutic effect of a drug. However, this has not been systematically investigated for escitalopram.
Luzie Eichentopf +30 more
doaj +1 more source
REM sleep in acutely traumatized individuals and interventions for the secondary prevention of post-traumatic stress disorder [PDF]
, 2020 Increasing evidence supports a close link between REM sleep and the consolidation of emotionally toned memories such as traumatic experiences. In order to investigate the role of sleep for the development of symptoms related to traumatic experiences ...
Bublitz, Jan Christoph +6 more
core +1 more source