Results 1 to 10 of about 43,016 (203)

Citalopram inhibits platelet function independently of SERT-mediated 5-HT transport [PDF]

Scientific Reports, 2018
Citalopram prevents serotonin (5-HT) uptake into platelets by blocking the serotonin reuptake transporter (SERT). Although some clinical data suggest that selective serotonin reuptake inhibitors (SSRIs) may affect haemostasis and thrombosis, these poorly-
Harvey G. Roweth, Ruoling Yan, Nader H. Bedwani, Alisha Chauhan, Nicole Fowler, Alice H. Watson, Jean-Daniel Malcor, Stewart O. Sage, Gavin E. Jarvis   +8 more
doaj   +4 more sources

In vitro assessment of the impact of 30 CYP2C19 variants on citalopram metabolism [PDF]

PeerJ
Background CYP2C19 polymorphisms are correlated with individual variability in response to citalopram treatment. The pharmacogenomic testing of CYP2C19 has been shown to optimize the safety and efficacy of citalopram medication. Exploration of the effect
Peng Wang, Xiao-xia Hu, Jun-wei Li
doaj   +3 more sources

Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs [PDF]

eLife
Administration of selective serotonin reuptake inhibitors (SSRIs) is associated with a reduced cancer risk and shows significant anti-tumor effects across multiple tumor types, suggesting the potential for repurposing SSRIs in cancer therapy. Nonetheless,
Fangyuan Dong, Shan Zhang, Kaiyuan Song, Luju Jiang, Li-Peng Hu, Qing Li, Xue-Li Zhang, Jun Li, Mingxuan Feng, Zhi-Wei Cai, Hong-Fei Yao, Rong-Kun Li, Hui Li, Jie Chen, Xiaona Hu, Jiaofeng Wang, Chongyi Jiang, Helen He Zhu, Cun Wang, Lin-Tai Da, Zhi-Gang Zhang, Zhijun Bao, Xu Wang, Shu-Heng Jiang   +23 more
doaj   +2 more sources

Influence of CYP2C19 Metabolizer Status on Escitalopram/Citalopram Tolerability and Response in Youth With Anxiety and Depressive Disorders

Frontiers in Pharmacology, 2019
In pediatric patients, the selective serotonin reuptake inhibitors (SSRIs) escitalopram and citalopram (es/citalopram) are commonly prescribed for anxiety and depressive disorders. However, pharmacogenetic studies examining CYP2C19 metabolizer status and
Lisa J Martin, Jeffrey R Strawn, Laura B Ramsey   +2 more
exaly   +3 more sources

Investigation into the Effects of Tramadol, Citalopram, Tianeptine, and Their Combinations on Rat Brain Tissue [PDF]

Biomedicines
Background: Tramadol binds to opioid receptors and inhibits norepinephrine and serotonin reuptake, causing serotonin syndrome. Tianeptine stimulates serotonin reuptake and reduces serotonin levels.
Irem Ates, Bahar Isik, Fusun Gozen, Gulce Naz Yazici, Mine Gulaboglu, Renad Mammadov, Gulbeniz Huseynova, Durdu Altuner, Halis Suleyman   +8 more
doaj   +2 more sources

Protective role of alcoholic extract of Juglans regia pulp in reducing the adverse effects of citalopram in the liver of male rats [PDF]

Open Veterinary Journal
Background: Citalopram is a class of antidepressant drugs that works by increasing the amount of serotonin to maintain mental balance. However, the risk of liver damage associated with citalopram use remains an area of ongoing research, with several ...
Mutashar Jaddoa Jiheel, Ahmed Dhahir Latif, Alwan Al Qushawi, Hasanain A. J. Gharban   +3 more
doaj   +2 more sources

Differential Metabolic Changes in Zebrafish Embryos Are Induced by Discontinued Citalopram Exposure [PDF]

Biomedicines
Background/Objectives: Citalopram is a selective serotonin reuptake inhibitor that is prescribed to relieve anxiety and depression. Widespread use has led to the contamination of freshwater systems downstream of wastewater treatment facilitates.
Gwendolyn Cooper, Ryan J. North, Dana Auganova, Christa S. Merzdorf, Brian Bothner   +4 more
doaj   +2 more sources

Comparative assessment of antidepressant-related behaviors of citalopram, crocin, and their combination in non-acute restraint stress and acute restraint stress mice [PDF]

IBRO Neuroscience Reports
Many studies demonstrated the role of citalopram (the bromohydrate of citalopram, which inhibits 5-HT reuptake) and crocin (a carotenoid chemical compound, antioxidant, antidepressant) in the modulation of depression-related behaviors.
Maryam Parhizkari, Fatemeh Khakpai, Mohammad-Reza Zarrindast   +2 more
doaj   +2 more sources

Citalopram and metacognitive therapy for depressive symptoms and cognitive emotion regulation in patients with major depressive disorder: A randomized controlled trial

Journal of Education and Health Promotion, 2020
BACKGROUND: Metacognitive therapy (MCT) is a new psychotherapy for depression. This study was conducted to compare the effectiveness of citalopram and MCT on major depressive disorders (MDDs).
Gholam Reza Kheirabadi, Zahra Yousefian, Fatemeh Zargar, Mahboobe Bahrami, Mohammad R Maracy   +4 more
doaj   +1 more source

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]

, 2013
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
A McQuillin, A Scimemi, AA Boucher, AD Michel, AJ Law, AM Basso, AN Guerra, AV Gourine, B Sperlagh, B Sperlagh, B Sperlagh, Beáta Sperlágh, BP Guiard, C Csolle, C Delarasse, C Lavebratt, C Toro, C Verderio, Cecilia Csölle, CG Thomas, CM Anderson, DS Hasin, DT Balu, E Castren, E Fuchs, E Mundo, E Shimizu, E. Sylvester Vizi, Edit Papp, EJ Nestler, EK Green, F Frenois, F Karege, Flóra Gölöncsér, G Nagy, G Nowak, G Sanacora, G Sanacora, G Sanacora, Gabriella Zsilla, GE Hardingham, GE Wood, JE Malberg, JF Cryan, JF Cryan, JH Meador-Woodruff, JL Warner-Schmidt, JM Boyce-Rustay, JM Krueger, JO Groves, JS Barnholtz, K Hashimoto, K Hejjas, K Martinowich, K Viwatpinyo, K Wager-Smith, KR Tovar, L Backlund, L Bocchio-Chiavetto, L Papp, L Papp, L Patti, L Santarelli, L Stokes, L Zhang, LM Monteggia, M Baranyi, M Barbera-Cremades, M Diaz-Hernandez, M Grigoroiu-Serbanescu, M Koehl, M Masin, M Solle, ME Kozisek, ME Kozisek, ME Szapacs, ML Barbaccia, MT Miras-Portugal, MW Pfaffl, Mária Baranyi, N Barden, N Drigues, O Berton, OH Lowry, P Fossati, P Skolnick, P Soronen, P Vanhoutte, PA Lapchak, Peter Illes, R Dantzer, RC Hogg, RJ Griffiths, RJ Rodrigues, RS Duman, S Alloisio, S Duan, S Lucae, S Monleon, S Schnydrig, SN Williams, SP Banerjee, T Balazsa, T Deltheil, T Deltheil, T Zigova, Thierry Amédée, V Shukla, VF Labrousse, VM Brautigam, W Peng, Y Dwivedi, Y Shirayama, Z Hracskó, Ágnes Kittel   +114 more
core   +6 more sources