Results 1 to 10 of about 19,804 (171)

Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs [PDF]

eLife
Administration of selective serotonin reuptake inhibitors (SSRIs) is associated with a reduced cancer risk and shows significant anti-tumor effects across multiple tumor types, suggesting the potential for repurposing SSRIs in cancer therapy. Nonetheless,
Fangyuan Dong, Shan Zhang, Kaiyuan Song, Luju Jiang, Li-Peng Hu, Qing Li, Xue-Li Zhang, Jun Li, Mingxuan Feng, Zhi-Wei Cai, Hong-Fei Yao, Rong-Kun Li, Hui Li, Jie Chen, Xiaona Hu, Jiaofeng Wang, Chongyi Jiang, Helen He Zhu, Cun Wang, Lin-Tai Da, Zhi-Gang Zhang, Zhijun Bao, Xu Wang, Shu-Heng Jiang   +23 more
doaj   +2 more sources

In vitro assessment of the impact of 30 CYP2C19 variants on citalopram metabolism [PDF]

PeerJ
Background CYP2C19 polymorphisms are correlated with individual variability in response to citalopram treatment. The pharmacogenomic testing of CYP2C19 has been shown to optimize the safety and efficacy of citalopram medication. Exploration of the effect
Peng Wang, Xiao-xia Hu, Jun-wei Li
doaj   +3 more sources

Influence of CYP2C19 Metabolizer Status on Escitalopram/Citalopram Tolerability and Response in Youth With Anxiety and Depressive Disorders

Frontiers in Pharmacology, 2019
In pediatric patients, the selective serotonin reuptake inhibitors (SSRIs) escitalopram and citalopram (es/citalopram) are commonly prescribed for anxiety and depressive disorders. However, pharmacogenetic studies examining CYP2C19 metabolizer status and
Stacey L. Aldrich, Stacey L. Aldrich, Ethan A. Poweleit, Cynthia A. Prows, Cynthia A. Prows, Lisa J. Martin, Lisa J. Martin, Jeffrey R. Strawn, Jeffrey R. Strawn, Laura B. Ramsey, Laura B. Ramsey   +10 more
doaj   +3 more sources

Differential Metabolic Changes in Zebrafish Embryos Are Induced by Discontinued Citalopram Exposure [PDF]

Biomedicines
Background/Objectives: Citalopram is a selective serotonin reuptake inhibitor that is prescribed to relieve anxiety and depression. Widespread use has led to the contamination of freshwater systems downstream of wastewater treatment facilitates.
Gwendolyn Cooper, Ryan J. North, Dana Auganova, Christa S. Merzdorf, Brian Bothner   +4 more
doaj   +2 more sources

Citalopram and metacognitive therapy for depressive symptoms and cognitive emotion regulation in patients with major depressive disorder: A randomized controlled trial

Journal of Education and Health Promotion, 2020
BACKGROUND: Metacognitive therapy (MCT) is a new psychotherapy for depression. This study was conducted to compare the effectiveness of citalopram and MCT on major depressive disorders (MDDs).
Gholam Reza Kheirabadi, Zahra Yousefian, Fatemeh Zargar, Mahboobe Bahrami, Mohammad R Maracy   +4 more
doaj   +1 more source

Oxidation of Citalopram with Sodium Hypochlorite and Chlorine Dioxide: Influencing Factors and NDMA Formation Kinetics

Molecules, 2019
The highly prescribed antidepressant, citalopram, as one of newly emerging pollutants, has been frequently detected in the aquatic environment. Citalopram oxidation was examined during sodium hypochlorite (NaOCl) and chlorine dioxide (ClO2) chlorination ...
Juan Lv, Yan Wang, Na Li
doaj   +1 more source

Safer citalopram use in primary care: Can staff education and prescribing prompts improve adherence to national guidance? A closed loop clinical audit, service evaluation and quality improvement study

Journal of Family Medicine and Primary Care, 2022
Background: Citalopram is a drug with many important safety considerations in prescribing including dosage adjustments, pre-prescription testing and multiple interactions.
Mark Waller
doaj   +1 more source

The Pharmacology of Citalopram Enantiomers: The Antagonism by R‐Citalopram on the Effect of S‐Citalopram* [PDF]

Basic & Clinical Pharmacology & Toxicology, 2006
Abstract: Recent results on the in vivo and in vitro pharmacology of escitalopram are summarised. The exact molecular mechanism by which R‐citalopram inhibits the effect of S‐citalopram on the serotonin transporter remains to be elucidated. Preliminary evidence indicates an effect of R‐citalopram on the association of escitalopram with the high ...
openaire   +2 more sources

Tris (2-aminoethyl) Amine Functionalized Nanoporous Silica SBA-15 as a Potential Drug Carrier for Citalopram [PDF]

International Journal of Basic Science in Medicine, 2019
Introduction: Ordered nanoporous silica such as SBA-15 has a great potential for application in controlled drug release systems. Chemical modification of the silanol groups of SBA-15 allows better control over drug loading and release.
Fatemeh Dalayi, Leila Hajiaghababaei, Alireza Badiei, Elham Boorboor Azimi, Mohammad Reza Ganjali, Ghodsi Mohammadi Ziarani   +5 more
doaj   +1 more source

Combination of Citalopram and Nortriptyline in the Treatment of Obsessive-Compulsive Disorder: A Double – Blind, Placebo-Controlled Trial [PDF]

Iranian Journal of Psychiatry, 2006
Objective: The fact that some antidepressants with strong effects on serotonin reuptake blockade fail to relieve obsessive-compulsive symptoms has caused growing interest in investigating noradrenergic function in obsessive-compulsive disorder (OCD) . In
Firoozeh Raisi, Marzieh Tavakoli, Abbas Ali Nasehi   +2 more
doaj   +1 more source