Determination of Nitrosamine Drug Substance-Related Impurities Derived from Nortriptyline and Sertraline Using LC-MS/MS: A Comparative Evaluation of Chromatographic Separation and Pharmaceutical Application [PDF]
PharmaceuticalsBackground/Objectives: Nitrosamine drug substance-related impurities (NDSRIs) are a class of potent genotoxic impurities that pose a critical risk to patient safety, thereby necessitating the stringent control of pharmaceutical products.
Minki Shim +5 more
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Health Technology AssessmentBackground There is insufficient evidence on the effectiveness of different antidepressants in Parkinson’s disease. This trial was commissioned to provide robust evidence regarding the effectiveness of a tricyclic and a selective serotonin reuptake ...
Anette Schrag +12 more
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Comparative cohort study of pregabalin nortriptyline and pregabalin duloxetine in the management of diabetic peripheral neuropathic pain [PDF]
Scientific ReportsDiabetic Peripheral Neuropathic Pain (DPNP) is a chronic complication affecting nearly half of individuals with diabetes. While monotherapies like pregabalin, duloxetine, and nortriptyline are frequently used, combination regimens may offer enhanced ...
Prathyusha Chowdary Dasari +8 more
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Short-term Effects of Nortriptyline on Sleep Parameters for Residual OSA after UPPP [PDF]
Iranian Journal of OtorhinolaryngologyIntroduction: Uvulopalatopharyngoplasty (UPPP) surgery, though helpful, may not always achieve optimal results for obstructive sleep apnea (OSA). This prospective, uncontrolled trial investigates the potential of nortriptyline in improving symptoms and ...
Reza Hosseini +4 more
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Effect of topical application of amitriptyline and nortriptyline on irreversible pulpitis pain in teeth with failed pulpal anesthesia after a successful inferior alveolar nerve block: A randomized clinical trial [PDF]
Dental Research JournalBackground: No consensus has been reached on the effect of topical application of amitriptyline and nortriptyline on irreversible pulpitis pain in teeth with failed pulpal anesthesia after a successful inferior alveolar nerve (IAN) block.
Armita Vali Sichani +4 more
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Nortriptyline overcomes corticosteroid resistance in NK and NKT-like cells from peripheral blood of patients with chronic obstructive pulmonary disease [PDF]
Research Results in Pharmacology, 2022 Introduction: An antidepressant nortriptyline potentiates glucocorticoid (GC) action with synergistic suppression of inflammatory mediator release, but the precise molecular mechanism is unknown.
Aliaksei G. Kadushkin +5 more
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Frontiers in Pharmacology, 2021 The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics.
Johannes Matthaei +10 more
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Pharmaceutics, 2022 The aims of this study were to evaluate the feasibility of a nortriptyline (NT) formulation for transdermal administration and to assess the usefulness of an estimated kinetic parameter (kout) using the in vitro infinite dose technique to predict in vivo
Iris Usach +4 more
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Nortriptyline blood levels and clinical outcome: meta-analysis of published studies [PDF]
Brazilian Journal of Psychiatry, 2000 INTRODUCTION: An optimum range has been suggested for nortriptyline blood levels, above or below which patients respond poorly or do not respond at all to treatment.
Mônica G Ribeiro +5 more
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Fullerene (C20) as a sensing material for electrochemical detection of Nortriptyline: A theoretical study [PDF]
Journal of Chemistry Letters, 2022 Quantification of nortriptyline (NTP) as an antidepressant medicine is of great importance. Therefore, in this research, (NTP) adsorption on the surface of fullerene C20 was studied by density functional theory computations.
Beheshteh Ajdari, Saeid Abrahi Vahed
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