Results 1 to 10 of about 8,701 (163)

Determination of Nitrosamine Drug Substance-Related Impurities Derived from Nortriptyline and Sertraline Using LC-MS/MS: A Comparative Evaluation of Chromatographic Separation and Pharmaceutical Application [PDF]

Pharmaceuticals
Background/Objectives: Nitrosamine drug substance-related impurities (NDSRIs) are a class of potent genotoxic impurities that pose a critical risk to patient safety, thereby necessitating the stringent control of pharmaceutical products.
Minki Shim, Ji Yeon Kim, Seungjin Jung, Minkyeong Hong, Sang Beom Han, Dong-Kyu Lee   +5 more
doaj   +2 more sources

Effectiveness of Escitalopram and Nortriptyline on Depressive Symptoms in Parkinson’s disease: the ADepT-PD RCT pilot

Health Technology Assessment
Background There is insufficient evidence on the effectiveness of different antidepressants in Parkinson’s disease. This trial was commissioned to provide robust evidence regarding the effectiveness of a tricyclic and a selective serotonin reuptake ...
Anette Schrag, Camille Carroll, Glyn Lewis, Marc Serfaty, Gordon Duncan, Sophie Molloy, John Whipps, Blair McLennan, Jing Yi (Jessica) Weng, Rachael M Hunter, Caroline S Clarke, Nicholas Freemantle, Andrew Embleton-Thirsk   +12 more
doaj   +2 more sources

Comparative cohort study of pregabalin nortriptyline and pregabalin duloxetine in the management of diabetic peripheral neuropathic pain [PDF]

Scientific Reports
Diabetic Peripheral Neuropathic Pain (DPNP) is a chronic complication affecting nearly half of individuals with diabetes. While monotherapies like pregabalin, duloxetine, and nortriptyline are frequently used, combination regimens may offer enhanced ...
Prathyusha Chowdary Dasari, Anusha Chandu, Monisha Bodala, Sree Poojitha Bandaru, Umesh Chandra Chundu, Pavan Sai Nelluri, Sreeram Thiriveedhi, Chetanya Bhatti, Suman Maharjan   +8 more
doaj   +2 more sources

Short-term Effects of Nortriptyline on Sleep Parameters for Residual OSA after UPPP [PDF]

Iranian Journal of Otorhinolaryngology
Introduction: Uvulopalatopharyngoplasty (UPPP) surgery, though helpful, may not always achieve optimal results for obstructive sleep apnea (OSA). This prospective, uncontrolled trial investigates the potential of nortriptyline in improving symptoms and ...
Reza Hosseini, Pedram Borghei, Amin Amali, Reihaneh Heidari, Reza Erfanian   +4 more
doaj   +2 more sources

Nortriptyline overcomes corticosteroid resistance in NK and NKT-like cells from peripheral blood of patients with chronic obstructive pulmonary disease [PDF]

Research Results in Pharmacology, 2022
Introduction: An antidepressant nortriptyline potentiates glucocorticoid (GC) action with synergistic suppression of inflammatory mediator release, but the precise molecular mechanism is unknown.
Aliaksei G. Kadushkin, Anatoli D. Tahanovich, Lyudmila V. Movchan, Volha V. Dziadzichkina, Olga V. Levandovskaya, Tatsiana V. Shman   +5 more
doaj   +3 more sources

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients

Frontiers in Pharmacology, 2021
The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics.
Johannes Matthaei, Jürgen Brockmöller, Werner Steimer, Konstanze Pischa, Stefan Leucht, Maria Kullmann, Ole Jensen, Typhaine Ouethy, Mladen Vassilev Tzvetkov, Mladen Vassilev Tzvetkov, Muhammad Rafehi   +10 more
doaj   +1 more source

Analgesic Effects of Repetitive Transcranial Magnetic Stimulation at Different Stimulus Parameters for Neuropathic Pain: A Randomized Study

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives The aim of the present study was to investigate the analgesic effects of repetitive transcranial magnetic stimulation over the primary motor cortex (M1‐rTMS) using different stimulation parameters to explore the optimal stimulus condition for treating neuropathic pain.
Nobuhiko Mori, Koichi Hosomi, Asaya Nishi, Satoru Oshino, Haruhiko Kishima, Youichi Saitoh   +5 more
wiley   +1 more source

The Usefulness of In Vitro Percutaneous Absorption Experiments Applying the Infinite Dose Technique to Predict In Vivo Plasma Levels: Comparison of Model-Predicted and Observed Plasma Concentrations of Nortriptyline in Rats

Pharmaceutics, 2022
The aims of this study were to evaluate the feasibility of a nortriptyline (NT) formulation for transdermal administration and to assess the usefulness of an estimated kinetic parameter (kout) using the in vitro infinite dose technique to predict in vivo
Iris Usach, Sara Di Marco, Octavio Díez, Manuel Alós, José-Esteban Peris   +4 more
doaj   +1 more source

Fullerene (C20) as a sensing material for electrochemical detection of Nortriptyline: A theoretical study [PDF]

Journal of Chemistry Letters, 2022
Quantification of nortriptyline (NTP) as an antidepressant medicine is of great importance. Therefore, in this research, (NTP) adsorption on the surface of fullerene C20 was studied by density functional theory computations.
Beheshteh Ajdari, Saeid Abrahi Vahed
doaj   +1 more source