Treatment of neuropathic pain in diabetic rats with synergistic combinations of nortriptyline + tramadol and nortriptyline + ibuprofen [PDF]
Frontiers in PharmacologyIntroductionNeuropathic pain in diabetic patients is very difficult to treat and does not respond to conventional analgesic treatments. It has been observed that tricyclic antidepressants are able to reduce this type of pain.
M. Gicela Pérez-Hernández +7 more
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Testing peripheral and central therapies for provoked vestibulodynia: results from the UPDATe trial [PDF]
Annals of MedicineIntroduction Vestibulodynia (VBD) is a common chronic pelvic pain condition with heterogeneous clinical presentation, including subtypes distinguished by the presence (VBD-central; VBD-c) or absence (VBD-peripheral; VBD-p) of comorbid pain conditions ...
Chloe Shudt +13 more
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Determination of Nitrosamine Drug Substance-Related Impurities Derived from Nortriptyline and Sertraline Using LC-MS/MS: A Comparative Evaluation of Chromatographic Separation and Pharmaceutical Application [PDF]
PharmaceuticalsBackground/Objectives: Nitrosamine drug substance-related impurities (NDSRIs) are a class of potent genotoxic impurities that pose a critical risk to patient safety, thereby necessitating the stringent control of pharmaceutical products.
Minki Shim +5 more
doaj +2 more sources
Comparative cohort study of pregabalin nortriptyline and pregabalin duloxetine in the management of diabetic peripheral neuropathic pain [PDF]
Scientific ReportsDiabetic Peripheral Neuropathic Pain (DPNP) is a chronic complication affecting nearly half of individuals with diabetes. While monotherapies like pregabalin, duloxetine, and nortriptyline are frequently used, combination regimens may offer enhanced ...
Prathyusha Chowdary Dasari +8 more
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Health Technology AssessmentBackground There is insufficient evidence on the effectiveness of different antidepressants in Parkinson’s disease. This trial was commissioned to provide robust evidence regarding the effectiveness of a tricyclic and a selective serotonin reuptake ...
Anette Schrag +12 more
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Nortriptyline overcomes corticosteroid resistance in NK and NKT-like cells from peripheral blood of patients with chronic obstructive pulmonary disease [PDF]
Research Results in Pharmacology, 2022 Introduction: An antidepressant nortriptyline potentiates glucocorticoid (GC) action with synergistic suppression of inflammatory mediator release, but the precise molecular mechanism is unknown.
Aliaksei G. Kadushkin +5 more
doaj +3 more sources
Frontiers in Pharmacology, 2021 The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics.
Johannes Matthaei +10 more
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Fullerene (C20) as a sensing material for electrochemical detection of Nortriptyline: A theoretical study [PDF]
Journal of Chemistry Letters, 2022 Quantification of nortriptyline (NTP) as an antidepressant medicine is of great importance. Therefore, in this research, (NTP) adsorption on the surface of fullerene C20 was studied by density functional theory computations.
Beheshteh Ajdari, Saeid Abrahi Vahed
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Journal of Mid-Life Health, 2019 Aims and Objectives: The aim of this study is to compare the effect of clonazepam and nortriptyline on rate, frequency, and severity of restless leg syndrome (RLS) in above 40 years women suffering from RLS.
Roshi +4 more
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Nortriptyline blood levels and clinical outcome: meta-analysis of published studies [PDF]
Brazilian Journal of Psychiatry, 2000 INTRODUCTION: An optimum range has been suggested for nortriptyline blood levels, above or below which patients respond poorly or do not respond at all to treatment.
Mônica G Ribeiro +5 more
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