Results 11 to 20 of about 9,052 (130)

A Re-Appraisal of Three Network Meta-Analyses to Explain the Discrepancy in Findings for the Efficacy of Fluoxetine for the Treatment of Depression in Children and Adolescents. [PDF]

Cochrane Evid Synth Methods
ABSTRACT Objective To explain discrepant findings for fluoxetine's efficacy in three influential network meta‐analyses (NMAs) of treatments for pediatric depression, which led to conflicting clinical recommendations. Design Critical appraisal and re‐analysis of three published NMAs.
Lyus R, Naudet F, van Valkenhoef G, Plöderl M.   +3 more
europepmc   +2 more sources

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Analgesic Effects of Repetitive Transcranial Magnetic Stimulation at Different Stimulus Parameters for Neuropathic Pain: A Randomized Study

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives The aim of the present study was to investigate the analgesic effects of repetitive transcranial magnetic stimulation over the primary motor cortex (M1‐rTMS) using different stimulation parameters to explore the optimal stimulus condition for treating neuropathic pain.
Nobuhiko Mori, Koichi Hosomi, Asaya Nishi, Satoru Oshino, Haruhiko Kishima, Youichi Saitoh   +5 more
wiley   +1 more source

The Role of the Antidepressants in Managing Chemotherapy-Induced Neuropathic Pain: A Systematic Review. [PDF]

Pharmacol Res Perspect
From symptom relief to multimodal care: duloxetine and amitriptyline may reduce established CIPN‐related pain and provide a therapeutic foundation for future combination strategies. ABSTRACT Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and debilitating complication of cancer treatment, characterized by neuropathic pain, sensory ...
Caminiti R, Mazza V, Nucera S, Oppedisano F, Passacatini LC, Maiuolo J, Malafoglia V, Giorgio A, Soluri A, Pileggi C, Tomino C, Mollace V, Ilari S, Muscoli C.   +13 more
europepmc   +2 more sources

Comparison of Melatonin versus Nortriptyline in Reducing Pain Severity in Patients with Painful Diabetic Polyneuropathy: A Randomized Double-Blind Clinical Trial [PDF]

Studies in Multidisciplinary Medical Research
Painful diabetic polyneuropathy (PDPN) is a common and debilitating complication of diabetes mellitus, often challenging to treat effectively. Nortriptyline, a tricyclic antidepressant, is a first-line treatment but is associated with significant side ...
Mohammad Rahimi, Mohammadali Bayani, Neda Meftah, Atena Rahimi, Payam Saadat, Hemmat Gholinia Ahangar   +5 more
doaj   +1 more source

The Usefulness of In Vitro Percutaneous Absorption Experiments Applying the Infinite Dose Technique to Predict In Vivo Plasma Levels: Comparison of Model-Predicted and Observed Plasma Concentrations of Nortriptyline in Rats

Pharmaceutics, 2022
The aims of this study were to evaluate the feasibility of a nortriptyline (NT) formulation for transdermal administration and to assess the usefulness of an estimated kinetic parameter (kout) using the in vitro infinite dose technique to predict in vivo
Iris Usach, Sara Di Marco, Octavio Díez, Manuel Alós, José-Esteban Peris   +4 more
doaj   +1 more source

Known Antimicrobials Versus Nortriptyline in Candida albicans: Repositioning an Old Drug for New Targets

Microorganisms, 2020
Candida albicans has the capacity to develop resistance to commonly used antimicrobials, and to solve this problem, drug repositioning and new drug combinations are being studied.
Marina Caldara, Nelson Marmiroli
doaj   +1 more source

Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation

Cell Communication and Signaling, 2023
Background Idiosyncratic drug-induced liver injury (IDILI) is common in hepatology practices and, in some cases, lethal. Increasing evidence show that tricyclic antidepressants (TCAs) can induce IDILI in clinical applications but the underlying ...
Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Wenzhang Dai, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao   +12 more
doaj   +1 more source

Simultaneous determination of nortriptyline hydrochloride and fluphenazine hydrochloride in microgram quantities from low dosage forms by liquid chromatography–UV detection

Journal of Pharmaceutical Analysis, 2012
A novel method for the simultaneous high-performance liquid chromatographic determination of nortriptyline hydrochloride and fluphenazine hydrochloride was developed and validated. Fluvastatin sodium was used as internal standard.
Safwan Ashour, Nuha Kattan
doaj   +1 more source

SPECTROPHOTOMETRIC AND SPECTROFLUORIMETRIC DETERMINATION OF AMINEPTINE AND NORTRIPTYLINE THROUGH TERNARY COMPLEX FORMATION WITH EOSIN AND Cu (II)

Zagazig Journal of Pharmaceutical Sciences, 1999
Two sensitive, spectrophotometric and spectrofluorimetric procedures are developed for the determination of two tricyclic antidepressant (amineptine hydrochloride and nortriptyline hydrochloride).
Magda Ayad , Hisham Abdellatef , Elham Taha , Suzan Soliman   +3 more
doaj   +1 more source