Results 41 to 50 of about 20,291 (261)

Adverse Effects of Antidepressants for Chronic Pain: A Systematic Review and Meta-analysis

Frontiers in Neurology, 2017
BackgroundAntidepressants are widely used in the treatment of chronic pain. Applied doses are lower than those needed to unfold an antidepressive effect.
Carina Riediger, Carina Riediger, Tibor Schuster, Kristian Barlinn, Sarah Maier, Sarah Maier, Sarah Maier, Jürgen Weitz, Timo Siepmann, Timo Siepmann   +9 more
doaj   +1 more source

City-wide Analysis of Electronic Health Records Reveals Gender and Age Biases in the Administration of Known Drug-Drug Interactions

, 2020
The occurrence of drug-drug-interactions (DDI) from multiple drug dispensations is a serious problem, both for individuals and health-care systems, since patients with complications due to DDI are likely to reenter the system at a costlier level.
Correia, Rion Brattig, de Araújo, Luciana P., Mattos, Mauro M., Rocha, Luis M.   +3 more
core   +1 more source

Cytokine-associated drug toxicity in human hepatocytes is associated signaling network dysregulation [PDF]

, 2009
Refer to Web version on PubMed Central for supplementary material.Idiosyncratic drug hepatotoxicity is a major problem in pharmaceutical development due to poor prediction capability of standard preclinical toxicity assessments and limited knowledge of ...
Ballif, Bart S. Hendriks, Benjamin D. Cosgrove, Bylesjö, Chokki, Clayton, Cosgrove, Cosgrove, Deng, Deng, Deng, Douglas A. Lauffenburger, Fielden, Ganey, Gaudet, Geladi, Gunawan, Hatano, Hotamisligil, Janes, Janes, Janes, Janes, Kaplowitz, Kaplowitz, Kemp, Kim, Kolls, Kumar, Kumar, Le, Lee, Leonidas G. Alexopoulos, Linda G. Griffith, Malhi, McCubrey, Miller-Jensen, Ono, Peter K. Sorger, Saez-Rodriguez, Sarbassov, Schwabe, Shaw, Ta-chun Hang, Tacke, Tukov, Wajant, Wold, Xu, Xu, Yuan   +50 more
core   +1 more source

Cost-effectiveness and budget impact analysis of smoking cessation interventions in chronic obstructive pulmonary disease patients in Thailand

Tobacco Induced Diseases, 2018
Background To determine the cost-effectiveness of different smoking cessation interventions in Thailand compared with unassisted cessation in chronic obstructive pulmonary disease (COPD) patients.
Ronnachai Kongsakon
doaj   +1 more source

Different patterns of cortical excitability in major depression and vascular depression: a transcranial magnetic stimulation study [PDF]

, 2013
BACKGROUND: Clinical and functional studies consider major depression (MD) and vascular depression (VD) as different neurobiological processes. Hypoexcitability of the left frontal cortex to transcranial magnetic stimulation (TMS) is frequently reported ...
Carmen Concerto, Concetto Spampinato, Daniela Giordano, Eugenio Aguglia, Giovanni Pennisi, Giuseppe Lanza, Manuela Pennisi, Mariagiovanna Cantone, Riccardo Ricceri, Rita Bella   +9 more
core   +2 more sources

Electrochemical Hofmann Rearrangement for Modular Synthesis of Unsymmetrical Ureas and Late‐Stage Modification of Drugs

Advanced Science, EarlyView.
An electrochemical Hofmann rearrangement of amide involving amine or other amide nucleophiles has been developed. The use of NaI guarantees the feasibility and compatibility of the electrosynthesis protocol, which enables highly chemoselective synthesis of unsymmetrical N‐acylureas from two different amides, as well as the production of unsymmetrical ...
Xue‐Qing Mou, Xiao Zha, Yu‐Rui Jian, Shao‐Xing Zhong, Xin‐Yu Fu, Sheng‐Yang Xu, Wei Xiang, Bao‐Dong Cui, Yun Zhang, Yong‐Zheng Chen   +9 more
wiley   +1 more source

ACCOUNTING FOR MONOTONE ATTRITION IN A POSTPARTUM DEPRESSION CLINICAL TRIAL [PDF]

, 2006
Longitudinal studies in public health, medicine and the social sciences are often complicated by monotone attrition, where a participant drops out before the end of the study and all his/her subsequent measurements are missing.
Roumani, Yazan
core  

Comparing the efficacy of duloxetine and nortriptyline in alleviating the symptoms of functional dyspepsia – a randomized clinical trial

Frontiers in Psychiatry
AimTo compare the efficacy of Duloxetine and Nortriptyline in alleviating the symptoms of severity, anxiety, depression and quality of life in patients with functional dyspepsia (FD).Material and methodWe conducted a single-blinded 3-month trial of ...
Seyed Shahab Banihashem, Seyedeh Mahsa Mofatioshieh, Reyhaneh Rastegar, Amir Sadeghi   +3 more
doaj   +1 more source

Adverse drug events associated with nortriptyline compared with paroxetine and alternative medications in an older adult population: a retrospective cohort study in Southern California

BMJ Open, 2023
Objective Investigate risk for falls, fractures and syncope in older adult patients treated with nortriptyline compared with paroxetine and alternative medications.Design Retrospective cohort study.Setting The electronic medical record and prescription ...
Monique Margaret George, Robert Louis Deamer, Duy Do   +2 more
doaj   +1 more source

Nortriptyline protects testes against germ cell apoptosis and oxidative stress induced by testicular ischaemia/reperfusion

Andrologia, 2017
We designed this experiment to evaluate the effects of nortriptyline on testicular injury after torsion/detorsion (T/D). Ninety‐six adult Wistar rats were divided into six groups 16 each in control group (Group 1), sham operated (Group 2), T/D + saline ...
I. Yazdani, M. Ghazi-Khansari, Seyed Soheil Saeedi Saravi, Seyed Soheil Saeedi Saravi, M. Nobakht, R. Majdani, S. Rezayat, S. Mousavi, S. Mousavi, A. Yari, A. Dehpour   +10 more
semanticscholar   +1 more source