Major depression with ischemic heart disease: Effects of paroxetine and nortriptyline on long-term heart rate variability measures [PDF]
Background: Studies have linked depression to sudden death and serious cardiovascular events in patients with preexisting cardiac illness. Recent studies have shown decreased vagal function in cardiac patients with depression and depressed patients ...
Jayaraman, A. +3 more
core
Objective: Drug repurposing, the application of existing therapeutics to new indications, holds promise in achieving rapid clinical effects at a much lower cost than that of de novo drug development.
Xi Cheng +8 more
doaj +1 more source
Preparation and Evaluation of Microbial Resistance of Nortriptyline Mouthwash Based on Pharmaceutical Pharmacopoeia Standards with the Aim of Application in Oral Mucositis [PDF]
Background: Oral mucositis as a complication of chemotherapy has posed significant challenges to the quality of life in cancer patients. Tricyclic antidepressants, including nortriptyline can control the pain caused by mucositis by inhibiting sodium ...
Taher Sadeghian, Saeideh Allahyari
doaj
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen +7 more
wiley +1 more source
USING TRAJECTORIES FROM A BIVARIATEGROWTH CURVE OF COVARIATES IN A COXMODEL ANALYSIS [PDF]
In many maintenance treatment trials, patients are first enrolled into an open treatmentbefore they are randomized into treatment groups. During this period, patients are followedover time with their responses measured longitudinally. This design is very
Dang, Qianyu
core +1 more source
Does publication bias inflate the apparent efficacy of psychological treatment for major depressive disorder? A systematic review and meta-analysis of US national institutes of health-funded trials [PDF]
Background The efficacy of antidepressant medication has been shown empirically to be overestimated due to publication bias, but this has only been inferred statistically with regard to psychological treatment for depression.
A DiMascio +85 more
core +8 more sources
RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run +7 more
wiley +1 more source
Major depression with ischemic heart disease: Effects of paroxetine and nortriptyline on measures of nonlinearity and chaos of heart rate [PDF]
Depression is associated with increased cardiovascular mortality in patients with preexisting cardiac illness. A decrease in cardiac vagal function as suggested by a decrease in heart rate variability (HRV) or heart period variability has been linked to ...
Mallavarapu, M. +4 more
core
Background: The incidence of depression is 0.9% in preschoolers, 1.9% in school age children, and 4.7% in adolescents. Current antidepressant treatment of mood disorders in children and adolescents is still in the early phases of being validated with ...
A Attari +4 more
doaj
Objectives This study aims to quantitatively analyse nortriptyline’s analgesic potency, safety and tolerability.Design Systematic review and meta-analysis.Data sources The systematic search was conducted in Scopus, Web of Science and PubMed in February ...
Soroush Hashemzadeh +2 more
doaj +1 more source

