Results 51 to 60 of about 20,291 (261)

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

Arthritis &Rheumatology, EarlyView.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun, Lingfang Xu, Haibing Chen, Mingshu Sun, Zhiqiang Li, Rui Li, Lidan Ma, Hui Zhang, Aichang Ji, Yuwei He, Na Wu, Le Yan, Robert Terkeltaub, Changgui Li   +13 more
wiley   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Analgesic Effect of Duloxetine Compared to Nortryptiline in Patients with painful Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Trial

Caspian Journal of Internal Medicine, 2021
Background:  Diabetic neuropathic pain (DNP) is a common complication of diabetes and has a profound effect on patients quality of life. Therefore. The purpose of the present study was to compare the analgesic effects of duloxetine and nortryptiline in ...
Mohammadali Bayani, Babak Moazammi, Farshad Fadaee-Jouybari, Mansour Babaei, Alijan Ahmadi-Ahangar, Payam Saadat   +5 more
doaj  

Nortriptyline, a tricyclic antidepressant, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells

Korean Journal of Physiology and Pharmacology, 2017
We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique.
S. Shin, Hongliang Li, Han Sol Kim, Hye Won Kim, M. Seo, K. Ha, E. Han, Seok-Ho Hong, A. Firth, I. Choi, Y. Bae, W. Park   +11 more
semanticscholar   +1 more source

Antidepressants and the risk of hyponatremia: A multi‐institutional cohort study using observational medical outcomes partnership—Common Data Model

British Journal of Clinical Pharmacology, EarlyView.
Aim Hyponatremia is a common yet potentially serious adverse event associated with antidepressants. Identifying the antidepressant class with the least risk of hyponatremia would improve patient safety. Methods Using electronic medical records from 15 hospitals standardized into Observational Medical Outcomes Partnership Common Data Model (2003–2023 ...
Kyungyeon Jung, Ju Hwan Kim, Da Eun Hyeon, Jeongmoon Ji, Min Young Lee, Hayun Choi, Dong Yun Lee, Min Woo Kim, Yoonmin Jang, Seonghoon Hwang, Jaehyeong Cho, Seok Young Song, Sang Youl Rhee, Jae Myung Cha, Won‐Woo Seo, Chang‐Won Jeong, Seung‐Jin Kwag, Woo Jin Kim, Jaeuk Hwang, Min‐ho Kim, Rae Woong Park, Ju‐Young Shin   +21 more
wiley   +1 more source

Experimental Pharmacological Research Regarding the Potential Antidepressant Activity Induced by Some Newly Synthesised Dibenzo[a,d]cycloheptene Compounds [PDF]

, 2015
Background. Depression is a relatively frequent encountered mental disorder in the general population, affecting both the quality of the individual life and its ability to perform the social tasks; it is generally accepted that new studies related to ...
Junghină, Adrian, Păunică, Ioana, Scutari, Corina, Ștefănescu, Emil   +3 more
core   +4 more sources

Consistency and clarity of pharmacogenomic guidance in UK medicine patient information leaflets: A cross‐sectional analysis

British Journal of Clinical Pharmacology, EarlyView.
Pharmacogenomic (PGx) information has the potential to support the safe and effective use of medicines, yet there is uncertainty about how this information can be best communicated to patients. Summaries of product characteristics (SmPCs) and patient information leaflets (PILs) for all UK‐approved medicines with strong evidence supporting a PGx ...
Parth Narlawar, Chloe Ratcliffe, Videha Sharma, William G. Newman, Munir Pirmohamed, John McDermott   +5 more
wiley   +1 more source

New Pharmacological Agents to Aid Smoking Cessation and Tobacco Harm Reduction: What has been Investigated and What is in the Pipeline? [PDF]

, 2016
A wide range of support is available to help smokers to quit and aid attempts at harm reduction, including three first-line smoking cessation medications: nicotine replacement therapy, varenicline and bupropion.
A Bisaga, A Jackson, A Kukkar, A Lenox-Smith, A Mann, A Parsons, A Sood, A Sood, A Verrotti, AE Evins, AH Glassman, AK Shinn, AM Joseph, AR Buchhalter, AS Rauhut, AV Prochazka, B Gaster, B Pasternak, B Spring, B Westenberger, BA Johnson, BF Grant, BM Kuehn, C Bullen, C Lerman, C Reavill, C Zona, C-Y Yeh, CA Martin, CD Cropp, CE Gartner, CF Koegelenberg, CL Bennett, CL DeVane, CL Strasinger, CT Bolliger, D Gonzales, D Hammond, D Kotz, D Kotz, D Kotz, D Mischoulon, D Moore, DA Baker, DA Baltieri, DA Revicki, Damian M. Cummings, DE Hilleman, DJ Romberger, DK Hatsukami, DK Hatsukami, DK Miller, DP Tashkin, E Beard, E Beard, E Beard, E Gere-Pászti, E Nowakowska, EA Finkelstein, EA Gilpin, EA McClure, EA Zimovetz, EC Westman, ED Levin, EG Guy, EH Cerny, EJ Jensen, EJ Mills, EJ Mills, EJ Wagena, Emma Beard, EW Tuan, F Wang, FT Filippidis, G Addolorato, G Chiara Di, G Cucchiaro, G Sutherland, GA Higgins, GM Keating, H Kitagawa, H McRobbie, H McRobbie, H Minami, H Myrick, H Pine-Abata, H-J Aubin, HM Schuller, I Berlin, J Balmford, J Brown, J Cornuz, J Foulds, J Foulds, J Kaper, J Kay, J Leaviss, J Ollivier, J Rose, J Shearer, J Shearer, J Yang, J-F Etter, J-G Gehricke, JA Dani, JE Henningfield, JE Henningfield, JE Rose, JE Rose, JE Sarginson, JF Rosenbaum, JM Ramon, JM Samet, JN Liberman, JO Ebbert, JO Ebbert, JR DiFranza, JR Hughes, JR Hughes, JS Ballon, JS Brown, JS Fowler, JW Lockner, K Bolin, K Demyttenaere, K Hara, K Ogita, K Silla, KA Holes-Lewis, KA Kasza, KA Perkins, KA Sacco, KC Waterman, KE Dunn, KE Farsalinos, KH Thomas, KP Garnock-Jones, KS Paudel, L Annemans, L Kozlowski, L Leggio, L Lima De, L Schmaal, L Shahab, L Shahab, LF Gaal Van, LH Ferry, Lion Shahab, LS Brose, LS Brose, LS Covey, M Farrell, M Harrison-Woolrych, M Hoogendoorn, M Khalifa, M Lader, M Mahmoudi, M McCarty, M Mugnaini, M Mula, M Neovius, M Ng, M Pravetoni, M Pravetoni, M Raw, M Raw, M Sofuoglu, M Sofuoglu, M Sofuoglu, M Sofuoglu, M Williams, M Wimbiscus, MA Jacobs, MA Russell, MA Russell, MC Fiore, ME Hadwiger, ME Jarvik, ME Jarvik, ME Mooney, ME Page, ME Thase, MFG Murphy, MG LeSage, MG LeSage, MH Ebell, MH Rapaport, ML Goniewicz, MM Moran, MY Bertram, N Benowitz, N Lindblom, N Walker, N Woolacott, NB Edwards, NF Woolacott, NL Benowitz, P Aveyard, P Farid, P Franks, P Gerrard, P Hajek, P Hajek, P Hajek, P Hajek, P Jha, P Maurer, P Popik, PH Hoogsteder, PH Silverstone, PM Bet, PM Cinciripini, PS Masand, R Benyamin, R Freedman, R Niaura, R Niaura, R Ray, R Richmond, R Shytle, R Taylor, R West, R West, R West, R West, R West, R West, R West, RA Brown, RA Schnoll, RA Schnoll, RB Barlow, RC Smith, RD Hurt, RD Hurt, RE Fahim, RF Yoshimura, RM Anthenelli, RM Pinder, Robert West, S Brimijoin, S Denford, S Greenland, S Leonard, S Shiffman, S Shiffman, S Shiffman, S Shiffman, S Singh, S Thornley, S Tonstad, S Tonstad, S Wanwimolruk, SA Ornish, SC Licata, SD Hall, SD Satoskar, SE Adkison, SH Villiers de, SL McElroy, SM Boekholdt, SM Holliday, SP Lakshmi, SS Hecht, Susan Michie, T Blondal, T Green, T Paparrigopoulos, T Raupach, TB Johnstone, TE Langley, TE Meyer, TJ Meine, TL Awtry, TM Luger, TR Franklin, U Eckstein-Ludwig, U Perngparn, V Butterweck, V Gligorijevic, V Klimek, V Varga, V Vengeliene, VS Kumar, W Berrettini, W Hao, W Pichayakorn, W Qiumei, WI Najm, WR Hiatt, X Shen, Y Buggy, Y Khazaal, Y-S Kim   +293 more
core   +1 more source

Depression-Associated Gene Negr1-Fgfr2 Pathway Is Altered by Antidepressant Treatment

Cells, 2020
The Negr1 gene has been significantly associated with major depression in genetic studies. Negr1 encodes for a cell adhesion molecule cleaved by the protease Adam10, thus activating Fgfr2 and promoting neuronal spine plasticity.
Lucia Carboni, Francesca Pischedda, Giovanni Piccoli, Mario Lauria, Laura Musazzi, Maurizio Popoli, Aleksander A. Mathé, Enrico Domenici   +7 more
doaj   +1 more source

Drug Critical Limits for Urgent Physician Notification

Clinical Pharmacology &Therapeutics, EarlyView.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost   +3 more
wiley   +1 more source