Results 31 to 40 of about 8,701 (163)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Comparison of Efficacy of Fluoxetine with Nortriptyline in Treatment of Major Depression in Children and Adolescents: a double-blind study

Journal of Research in Medical Sciences, 2006
Background: The incidence of depression is 0.9% in preschoolers, 1.9% in school age children, and 4.7% in adolescents. Current antidepressant treatment of mood disorders in children and adolescents is still in the early phases of being validated with ...
A Attari, F Yadollah Moghaddam, A Hasanzadeh, M Soltani, M Mahmoodi   +4 more
doaj  

Comparison of pharmacogenomic guidance in Australian prescribing resources and international pharmacogenomic guidelines

Internal Medicine Journal, EarlyView.
Abstract Background Pharmacogenomic‐guided medication management optimises drug therapy to enhance patient outcomes. Despite clinical utility, implementation in Australia remains limited, partly due to the lack of clear and consistent guidance. Aim This study evaluated the presence and consistency of pharmacogenomic testing indication categories and ...
Ruby Soueid, Jackson L. A. Thomas, Luke B. Hesson, Stephen Hughes, Sophie L. Stocker   +4 more
wiley   +1 more source

Analgesic Effect of Duloxetine Compared to Nortryptiline in Patients with painful Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Trial

Caspian Journal of Internal Medicine, 2021
Background:  Diabetic neuropathic pain (DNP) is a common complication of diabetes and has a profound effect on patients quality of life. Therefore. The purpose of the present study was to compare the analgesic effects of duloxetine and nortryptiline in ...
Mohammadali Bayani, Babak Moazammi, Farshad Fadaee-Jouybari, Mansour Babaei, Alijan Ahmadi-Ahangar, Payam Saadat   +5 more
doaj  

A randomized clinical trial of metacognitive therapy and nortriptyline for anxiety, depression, and difficulties in emotion regulation of patients with functional dyspepsia

Research in Psychotherapy, 2020
Functional Dyspepsia (FD) as a psychosomatic disorder is an upper gastrointestinal tract disease without organic pathogenesis causes. The psychopathological nature of this disease and its high correlation with anxiety and depression implies the need for ...
Sepideh Batebi, Abbas Masjedi Arani, Mahdi Jafari, Amir Sadeghi, Mohsen Saberi Isfeedvajani, Mohammad Hasan Davazdah Emami   +5 more
doaj   +1 more source

Adverse drug events associated with nortriptyline compared with paroxetine and alternative medications in an older adult population: a retrospective cohort study in Southern California

BMJ Open, 2023
Objective Investigate risk for falls, fractures and syncope in older adult patients treated with nortriptyline compared with paroxetine and alternative medications.Design Retrospective cohort study.Setting The electronic medical record and prescription ...
Monique Margaret George, Robert Louis Deamer, Duy Do   +2 more
doaj   +1 more source

Monotherapy versus combination therapy in the prophylaxis of episodic migraine: A retrospective study

Cephalalgia Reports
Background Preventive therapy is a key element of migraine management, and there is limited evidence comparing monotherapy and combination regimens of established agents.
Abouch Valenty Krymchantowski, Carla Jevoux, Ana Gabriela Krymchantowski, Yasmine Maria Leódido Fortes, Raimundo Pereira Silva-Néto   +4 more
doaj   +1 more source

Quantitative analysis of nortriptyline’s analgesic properties: a comparative systematic review and meta-analysis

BMJ Open
Objectives This study aims to quantitatively analyse nortriptyline’s analgesic potency, safety and tolerability.Design Systematic review and meta-analysis.Data sources The systematic search was conducted in Scopus, Web of Science and PubMed in February ...
Soroush Hashemzadeh, Mohammad Mortazavi, Ramin Abdi Dezfouli   +2 more
doaj   +1 more source

Depression-Associated Gene Negr1-Fgfr2 Pathway Is Altered by Antidepressant Treatment

Cells, 2020
The Negr1 gene has been significantly associated with major depression in genetic studies. Negr1 encodes for a cell adhesion molecule cleaved by the protease Adam10, thus activating Fgfr2 and promoting neuronal spine plasticity.
Lucia Carboni, Francesca Pischedda, Giovanni Piccoli, Mario Lauria, Laura Musazzi, Maurizio Popoli, Aleksander A. Mathé, Enrico Domenici   +7 more
doaj   +1 more source