Results 31 to 40 of about 9,052 (130)

Evaluating the impact of varenicline shortages and a regulatory mitigation strategy on dispensing patterns of smoking cessation therapies in Australia: A retrospective interrputed time series study

Addiction, EarlyView.
Abstract Background and aims Australia experienced a prolonged varenicline shortage beginning June 2021, disrupting access to a key smoking cessation therapy. Section 19A (S19A) of the Therapeutic Goods Act permitted temporary importation of overseas‐approved products to mitigate this impact.
Chloe Weigall, Lisa Kalisch Ellett, Anna Kemp‐Casey, Nicole Pratt, Jacinta L. Johnson, Stephanie E. Reuter, Jack Luke Janetzki   +6 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Comparison of Efficacy of Fluoxetine with Nortriptyline in Treatment of Major Depression in Children and Adolescents: a double-blind study

Journal of Research in Medical Sciences, 2006
Background: The incidence of depression is 0.9% in preschoolers, 1.9% in school age children, and 4.7% in adolescents. Current antidepressant treatment of mood disorders in children and adolescents is still in the early phases of being validated with ...
A Attari, F Yadollah Moghaddam, A Hasanzadeh, M Soltani, M Mahmoodi   +4 more
doaj  

Adverse Effects of Antidepressants for Chronic Pain: A Systematic Review and Meta-analysis

Frontiers in Neurology, 2017
BackgroundAntidepressants are widely used in the treatment of chronic pain. Applied doses are lower than those needed to unfold an antidepressive effect.
Carina Riediger, Carina Riediger, Tibor Schuster, Kristian Barlinn, Sarah Maier, Sarah Maier, Sarah Maier, Jürgen Weitz, Timo Siepmann, Timo Siepmann   +9 more
doaj   +1 more source

Real‐world diagnosis and treatment of individuals with migraine in the United States: The Migraine Insights in Diagnosis and Treatment (MIND) study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The objective of this study was to describe the real‐world diagnosis and treatment patterns of individuals newly diagnosed with migraine in the United States (US). Background Over 10% of adults in the US are living with migraine.
Fred Cohen, Vincent Martin, Avani Patel, Shelby L. Corman, Katie B. Tellor, Meghan Fajardo, D. Cortney Hayflinger, Simon Dagenais   +7 more
wiley   +1 more source

Monotherapy versus combination therapy in the prophylaxis of episodic migraine: A retrospective study

Cephalalgia Reports
Background Preventive therapy is a key element of migraine management, and there is limited evidence comparing monotherapy and combination regimens of established agents.
Abouch Valenty Krymchantowski, Carla Jevoux, Ana Gabriela Krymchantowski, Yasmine Maria Leódido Fortes, Raimundo Pereira Silva-Néto   +4 more
doaj   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Quantitative analysis of nortriptyline’s analgesic properties: a comparative systematic review and meta-analysis

BMJ Open
Objectives This study aims to quantitatively analyse nortriptyline’s analgesic potency, safety and tolerability.Design Systematic review and meta-analysis.Data sources The systematic search was conducted in Scopus, Web of Science and PubMed in February ...
Soroush Hashemzadeh, Mohammad Mortazavi, Ramin Abdi Dezfouli   +2 more
doaj   +1 more source

A randomized clinical trial of metacognitive therapy and nortriptyline for anxiety, depression, and difficulties in emotion regulation of patients with functional dyspepsia

Research in Psychotherapy, 2020
Functional Dyspepsia (FD) as a psychosomatic disorder is an upper gastrointestinal tract disease without organic pathogenesis causes. The psychopathological nature of this disease and its high correlation with anxiety and depression implies the need for ...
Sepideh Batebi, Abbas Masjedi Arani, Mahdi Jafari, Amir Sadeghi, Mohsen Saberi Isfeedvajani, Mohammad Hasan Davazdah Emami   +5 more
doaj   +1 more source