Results 31 to 40 of about 43,016 (203)

The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning

Balkan Medical Journal, 2015
Background: Citalopram is a selective serotonin reuptake inhibitor that requires routine cardiac monitoring to prevent a toxic dose. Prolongation of the QT interval has been observed in acute citalopram poisoning.
Müjgan Büyükdeligöz, Nil Hocaoğlu, Kubilay Oransay, Yeşim Tunçok, Şule Kalkan   +4 more
doaj   +1 more source

Impact of the antidepressant citalopram on the behaviour of two different life stages of brown trout [PDF]

PeerJ, 2020
Background Over the last two decades, there has been a constant increase in prescription rates of antidepressants. In parallel, neuroactive pharmaceuticals are making their way into aquatic environments at increasing concentrations.
Michael Ziegler, Sarah Knoll, Heinz-R. Köhler, Selina Tisler, Carolin Huhn, Christian Zwiener, Rita Triebskorn   +6 more
doaj   +2 more sources

Palladium-catalyzed heteroallylation of unactivated alkenes – synthesis of citalopram [PDF]

, 2013
A palladium-catalyzed difunctionalization of unactivated alkenes with tethered nucleophiles is reported. The versatile reaction occurs with simple allylic halides and can be carried out under air.
Adams, Alcaide, Alexanian, Arai, Balme, Beccalli, Byers, Carruthers, Danishefsky, Deprez, Desai, Doroski, Fries, Fries, Fukuda, Giese, Guo, Hayashi, Hayashi, Heck, Hegedus, Hickman, Hopkins, Ingalls, Jensen, Kang, Keller, Kimura, Koester, Komeyama, Kumar, Larock, Larock, Le Bras, Lei, Li, Lira, Liskin, Liu, Liwosz, Lovering, Lu, Ma, Ma, Ma, Ma, Mai, Manzoni, McDonald, Michael, Minatti, Muñiz, Muñiz, Muñiz, Nadin, Neukom, Newman, Newman, Ney, Ney, Nicolai, Nicolai, Nicolai, Nicolai, Nishimura, Pappo, Ritchie, Rosewall, Schuch, Schultz, Sehnal, Semmelhack, Sibbald, Sibbald, Streuff, Sun, Tietze, Tietze, Trost, Trost, Trost, Tsuji, VanRheenen, Vedantham, Wakabayashi, Weaver, Wolfe, Wolfe, Wolfe, Wolfe, Wu, Xu, Yip, Yip, Yorimitsu, Yorimitsu, Zeni, Zhao, Zhu   +98 more
core   +1 more source

Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension [PDF]

, 2017
Objective: Serotonin can induce human pulmonary artery smooth muscle cell (hPASMC) proliferation through reactive oxygen species (ROS), influencing the development of pulmonary arterial hypertension (PAH). We hypothesise that in PASMCs, serotonin induces
Harvey, Adam P., Hood, Katie Y., MacLean, Margaret R., Mair, Kirsty M., Montezano, Augusto C., Touyz, Rhian M.   +5 more
core   +2 more sources

Citalopram – what you need to know about this proven antidepressant

Psychiatria i Psychologia Kliniczna, 2019
Citalopram is an antidepressant belonging to the group of selective serotonin reuptake inhibitors, a racemate consisting of two enantiomers: R-citalopram and S-citalopram, which show different pharmacological properties.
Piotr Wierzbiński
doaj   +1 more source

Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building. [PDF]

, 2012
A limitation in traditional stepwise population pharmacokinetic model building is the difficulty in handling interactions between model components. To address this issue, a method was previously introduced which couples NONMEM parameter estimation and ...
Belani, Chandra P, Bies, Robert R, Egorin, Merrill J, Ivy, Percy S, Lieberman, Jeffrey A, Manuck, Stephen B, Marder, Stephen R, Muldoon, Matthew F, Pollock, Bruce G, Sale, Mark E, Scher, Howard I, Sherer, Eric A, Solit, David B   +12 more
core   +3 more sources

Changes in QTc interval in the citalopram for agitation in Alzheimer's disease (CitAD) randomized trial. [PDF]

PLoS ONE, 2014
A Food and Drug Administration (FDA) safety communication in August 2011 warned that citalopram was associated with a dose dependent risk of QT prolongation and recommended dose restriction in patients over the age of 60 but did not provide data for this
Lea T Drye, David Spragg, D P Devanand, Constantine Frangakis, Christopher Marano, Curtis L Meinert, Jacobo E Mintzer, Cynthia A Munro, Gregory Pelton, Bruce G Pollock, Anton P Porsteinsson, Peter V Rabins, Paul B Rosenberg, Lon S Schneider, David M Shade, Daniel Weintraub, Jerome Yesavage, Constantine G Lyketsos, CitAD Research Group   +18 more
doaj   +1 more source

Clinical applications of personalized medicine: a new paradigm and challenge [PDF]

, 2017
The personalized medicine is an emergent and rapidly developing method of clinical practice that uses new technologies to provide decisions in regard to the prediction, prevention, diagnosis and treatment of disease.
Borro, Marina, DI SANZO, Mariantonia, Fineschi, Vittorio, Frati, Paola, LA RUSSA, Raffaele, Santurro, Alessandro, Scopetti, Matteo, Simmaco, Maurizio   +7 more
core   +1 more source

Chronic exposure to environmentally relevant levels of citalopram affects crawl-out behavior and morphological antipredator plasticity in a freshwater gastropod

Ecotoxicology and Environmental Safety
Citalopram is a commonly prescribed antidepressant and selective serotonin reuptake inhibitor (SSRI). Low wastewater treatment plant removal rates facilitate its ubiquity in natural surface waters.
Jamal Rahimi, Denis Meuthen
doaj   +1 more source

Effects of prenatal exposure to (es)citalopram and maternal depression during pregnancy on DNA methylation and child neurodevelopment

Translational Psychiatry, 2023
Studies assessing associations between prenatal exposure to antidepressants, maternal depression, and offspring DNA methylation (DNAm) have been inconsistent.
Emilie Willoch Olstad, Hedvig Marie Egeland Nordeng, Geir Kjetil Sandve, Robert Lyle, Kristina Gervin   +4 more
doaj   +1 more source