Results 51 to 60 of about 19,804 (171)

Virus‐specific alterations in placental structure and transporter expression following maternal arbovirus infection

The Journal of Physiology, EarlyView.
Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade, Enrrico Bloise, Natália L. Silva, Jair R. S. Braga, Sharton V. A. Coelho, Veronica M. O. Nascimento, Guinever E. Imperio, Camila O. S. Nunes, Antônio J. L. A. Cunha, Marcelo A. Pascoal‐Xavier, Luciana B. Arruda, Arnaldo Prata‐Barbosa, Kristin L. Connor, Tania M. Ortiga‐Carvalho   +13 more
wiley   +1 more source

Enantiomeric Analysis of Citalopram in Human Plasma by SPE and Chiral HPLC Method

International Journal of Electrochemical Science, 2011
Citalopram is a serotonin transporter (SERT) inhibitor and is used as a potent anti-depressant drug. S-(+)-Citalopram is twice therapeutically active than its racemic mixture. The present article describes effective, selective and reproducible methods of
V.K. Gupta, Imran Ali, Shilpi Agarwal
doaj   +1 more source

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 731-744, September 2026.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Long‐Term Therapy Experiences in Post‐suicidal Men: Safety, Gender and Iatrogenic Harm

MultiPsych, Volume 1, Issue 3, September 2026.
Men who have survived a suicide attempt and engaged in long‐term psychotherapy describe the therapeutic relationship as the primary agent of recovery—not technique, but sustained relational presence. Gender dynamics, developmental history and institutional failure all shape engagement. These findings challenge short‐term service models and carry direct
Alastair Coomes, Joel Vos, Ron Roberts
wiley   +1 more source

Evaluation of Typical Antipsychotic Augmentation with Citalopram in Reduction of Negative Symptoms in Inpatient Schizophrenia in Ahvaz Golestan Hospital

Majalah-i ̒ilmī pizishkī-i jundī/shapūr, 2012
Background and Objective: The aim of this study was to evaluate the efficacy of citalopram added to typical antipsychotic for the treatment of negative symptoms of inpatients with schizophrenia disorder in Ahvaz Golestan hospital.
Masome Nazari Nasab, Nilofar Khajeddin, Abdol Amin Shanesaz Abbas Pezeshki   +2 more
doaj  

Synergistic effect between citalopram and muscimol upon induction of anxiolytic- and antidepressant-like effects in male mice: An isobologram analysis

IBRO Neuroscience Reports
Background: There is evidence that both the GABAergic system and serotonin reuptake inhibitor (SSRI) such as citalopram are involved in the modulation of anxiety and depression processes. In this research, we examined the effects of GABAA receptor agents
Elnaz Amini, Taha Shokrnejad-namin, Mohammad-Reza Zarrindast, Fatemeh Khakpai   +3 more
doaj   +1 more source

Multi‐Modal AI Approach in Depression Detection and Treatment: A Systematic Review of Last Decade

WIREs Data Mining and Knowledge Discovery, Volume 16, Issue 3, September 2026.
Overview of multimodal approaches for depression detection and treatment. ABSTRACT Depression is a common and devastating mental health illness with serious personal and societal consequences. Despite advancing treatment techniques, there are still hurdles in the effective diagnosis and treatment of depression, such as prompt diagnosis, personalized ...
Smith K. Khare, Esmaeil S. Nadimi, U. Rajendra Acharya, Victoria Blanes‐Vidal   +3 more
wiley   +1 more source

Tratamento farmacológico da gagueira: evidências e controvérsias Pharmacologic treatment of stuttering: evidences and controversies

Jornal Brasileiro de Psiquiatria, 2006
OBJETIVO: Este artigo tem por objetivo analisar a situação do tratamento farmacológico da gagueira, mostrando a eficácia de diferentes abordagens baseadas em drogas psiquiátricas, além de evidenciar a utilização de outros fármacos no tratamento dessa ...
Camila Vila-Nova, Fernanda Queirós, Thiago Fortaleza, Rita Lucena   +3 more
doaj   +1 more source

Deprescription of Psychotropics in Children and Adolescents: Systematic Review of Guidelines and Development of a Deprescribing Algorithm

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Background Psychotropics are increasingly prescribed in paediatrics despite limited evidence regarding their benefits and effectiveness. Although deprescribing approaches are established in adults, structured paediatric strategies remain poorly defined.
Paul‐Benoît Fargier, Mark Horowitz, Rodolphe Charles, Valérie Rousselon, Erik Fakra, Marie‐Noëlle Beyens, Marie‐Laure Laroche   +6 more
wiley   +1 more source

Uncovering Modifiable Contributors to Depressive Symptoms During Antidepressant Prescription Renewal: A Primary Care Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Depressive symptoms in primary care often arise from a complex interplay of hormonal, biological, metabolic, psychosocial, and lifestyle factors. We present the case of a 41‐year‐old woman whose depressive symptoms began three months postpartum after her second pregnancy and persisted for approximately five years.
Leonora Muhadri, Hong Phan
wiley   +1 more source