Results 61 to 70 of about 22,136 (209)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

A rare presentation of escitalopram overdose-induced bradycardia and arrhythmia in a patient with severe depression

Telangana Journal of Psychiatry
Escitalopram is the most commonly used selective serotonin reuptake inhibitor. Escitalopram toxicity leads to serotonin syndrome, seizures, and cardiac side effects which include QTc prolongation, arrhythmias, and bradycardia.
Anand Bhogaraju, Yasaswi Kadaru, Tabitha Jezreel   +2 more
doaj   +1 more source

Escitalopram-induced spasmodic torticollis in an early psychosis service: a case report

Escitalopram-induced dystonia is a rare but clinically important occurrence.
Kelbrick, Marlene, Mustafa, Feras Ali, Walker, Jonny, Elhardlu, Hala   +3 more
core   +1 more source

Superiority of escitalopram to paroxetine in the treatment of depression

, 2009
Post-hoc pooled analysis of data from two 6-month randomised controlled trials in patients with major depressive disorder (MDD) revealed superior efficacy and tolerability of escitalopram when compared with paroxetine.
Kasper, Siegfried, Boulenger, Jean-Philippe, Lönn, Sara Larsson, Baldwin, David S.   +3 more
core   +1 more source

Comparison of the Effect of Sertraline and Escitalopram on the Treatment of Major Depressive Disorder in Hemodialysis Patients: A Randomized Controlled Trial

Novelty in Biomedicine
Background: We decided to compare the effects of sertraline and escitalopram in the treatment of major depressive disorder in hemodialysis patients. Materials and Methods: In this single-blind randomized clinical trial, 100 patients with End-Stage ...
Tahereh Sabaghian, Roya Vaziri-Harami, Seyed Alireza Ebadi, Minoo Heidari Almasi, Azadeh Ahmadi Koomleh, Amir Behnam Kharazmi, Ehsan Farhadi, Mahdiyeh Miri, Amir Ahmad Nassiri   +8 more
doaj   +1 more source

Escitalopram induced peripheral edema: A case report

Psychiatry and Clinical Psychopharmacology, 2021
Escitalopram, a selective serotonin reuptake inhibitor (SSRI) which is widely prescribed by both psychiatrists and other physicians because of its minimal adverse effects.
Hayriye Baykan, Lütfi İlhan Yargıç
doaj  

Are old-old patients with major depression more likely to relapse than young-old patients during continuation treatment with escitalopram?

BMC Geriatrics, 2011
Background Escitalopram has shown efficacy and tolerability in the prevention of relapse in elderly patients with major depressive disorder (MDD). This post-hoc analysis compared time to relapse for young-old patients (n = 197) to that for old-old ...
Katona Cornelius, Weiller Emmanuelle, Lyketsos Constantine G, Gorwood Phillip   +3 more
doaj   +1 more source

Comparing the Efficacy of Escitalopram with and without Crocin in Restoring I/O Functions and LTP within the Hippocampal CA1 Region of Stressed Rats

Advanced Biomedical Research
Background: Escitalopram, a pharmacological compound, and crocin, the active compound of saffron, influence brain functions and serotonin levels. This study examined the efficacy of escitalopram with and without crocin in restoring the input-output (I/O)
Mehran Joodaki, Maryam Radahmadi, Hojjatallah Alaei   +2 more
doaj   +1 more source

Integrating Pharmacogenomic Testing Within the 4Ms Framework for Management of Behavioral Symptoms in Advanced Vascular Dementia: A Case Study

Journal of the American Geriatrics Society, EarlyView.
Pharmacogenomic‐guided managment of behavioral symptoms within the 4Ms framework.
Gianna Franco, Collins Njoku, Mary L. Wagner, Fred A. Kobylarz   +3 more
wiley   +1 more source