Results 31 to 40 of about 1,279 (113)

Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis

Frontiers in Immunology, 2019
Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course.
Leyre Mestre, Leyre Mestre, Francisco Javier Carrillo-Salinas, Miriam Mecha, Miriam Mecha, Ana Feliú, Ana Feliú, Carmen Espejo, Carmen Espejo, Carmen Espejo, José Carlos Álvarez-Cermeño, José Carlos Álvarez-Cermeño, Luisa María Villar, Luisa María Villar, Carmen Guaza, Carmen Guaza   +15 more
doaj   +1 more source

A guide to treating gait impairment with prolonged-release fampridine (Fampyra®) in patients with multiple sclerosis

Neurología (English Edition), 2018
Introduction: Gait impairment, a frequent sign in multiple sclerosis (MS), places a major burden on patients since it results in progressive loss of personal and social autonomy, along with work productivity. This guide aims to provide recommendations on
L. Ramió-Torrentà, J.C. Álvarez-Cermeño, R. Arroyo, B. Casanova-Estruch, O. Fernández, J.A. García-Merino, M.A. Hernández, G. Izquierdo, S. Martínez-Yélamos, J. Meca, E. Moral, J. Olascoaga, J.M. Prieto, A. Saiz   +13 more
doaj   +1 more source

Guía de tratamiento del deterioro de la marcha con fampridina de liberación prolongada (Fampyra®) en pacientes con esclerosis múltiple

Neurología, 2018
Resumen: Introducción: La alteración de la marcha es frecuente en la esclerosis múltiple (EM) y tiene un gran impacto negativo en los pacientes pues conlleva a la pérdida progresiva de autonomía personal y social, y de productividad laboral.
L. Ramió-Torrentà, J.C. Álvarez-Cermeño, R. Arroyo, B. Casanova-Estruch, O. Fernández, J.A. García-Merino, M.A. Hernández, G. Izquierdo, S. Martínez-Yélamos, J. Meca, E. Moral, J. Olascoaga, J.M. Prieto, A. Saiz   +13 more
doaj   +1 more source

Short- and Long-Term Humoral and Cellular Immune Responses to SARS-CoV-2 Vaccination in Patients with Multiple Sclerosis Treated with Disease-Modifying Therapies

Vaccines, 2023
Background: This study aimed to evaluate short- and long-term humoral and T-cell-specific immune responses to SARS-CoV-2 vaccines in patients with multiple sclerosis (MS) treated with different disease-modifying therapies (DMTs).
Susana Sainz de la Maza, Paulette Esperanza Walo-Delgado, Mario Rodríguez-Domínguez, Enric Monreal, Alexander Rodero-Romero, Juan Luis Chico-García, Roberto Pariente, Fernando Rodríguez-Jorge, Rubén Ballester-González, Noelia Villarrubia, Beatriz Romero-Hernández, Jaime Masjuan, Lucienne Costa-Frossard, Luisa María Villar   +13 more
doaj   +1 more source

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, Volume 12, Issue 9, Page 1894-1900, September 2025.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source

Recommendations for using and interpreting magnetic resonance imaging in multiple sclerosis

Neurología (English Edition), 2010
Objective: To establish recommendations for using and interpreting magnetic resonance imaging (MRI) results in the diagnosis and follow up of multiple sclerosis (MS).
A. Rovira, M. Tintoré, J.C. Álvarez-Cermeño, G. Izquierdo, J.M. Prieto   +4 more
doaj   +1 more source

How oral probiotics affect the severity of an experimental model of progressive multiple sclerosis? Bringing commensal bacteria into the neurodegenerative process

Gut Microbes, 2020
A growing number of studies support that the bidirectional interactions between the gut microbiota, the immune system and the CNS are relevant for the pathophysiology of MS.
Leyre Mestre, Francisco J. Carrillo-Salinas, Ana Feliú, Miriam Mecha, Graciela Alonso, Carmen Espejo, Laura Calvo-Barreiro, José L. Luque-García, Héctor Estevez, Luisa María Villar, Carmen Guaza   +10 more
doaj   +1 more source

Recomendaciones para la utilización e interpretación de los estudios de resonancia magnética en la esclerosis múltiple

Neurología, 2010
Resumen: Objetivo: Establecer unas recomendaciones para utilizar e interpretar la resonancia magnética (RM) en el diagnóstico y el seguimiento de la esclerosis múltiple (EM).
A. Rovira, M. Tintoré, J.C. Álvarez-Cermeño, G. Izquierdo, J.M. Prieto   +4 more
doaj   +1 more source

Evaluación de la calidad de vida en Esclerosis Múltiple a través del MSQOL-54 y su relación con la salud de la persona

Enfermería Global, 2021
Objetivo: El objetivo del presente estudio fue evaluar la Calidad de Vida Relacionada con la salud (CVRS) en personas con Esclerosis Múltiple (EM) mediante el cuestionario MSQOL-54 y analizar su relación con la salud de las personas cuidadoras ...
María Dolores Martínez-Espejo, Rosa María Limiñana-Gras, Rosa María Patró-Hernández, José Eustasio Meca Lallana, Encarnación Aznar Robles, María del Carmen Márquez Rebollo   +5 more
doaj   +1 more source

Short‐chain fatty acids in multiple sclerosis: Associated with disability, number of T2 lesions, and inflammatory profile

Annals of Clinical and Translational Neurology, Volume 12, Issue 3, Page 478-490, March 2025.
Abstract Objective An alteration in the composition of the intestinal microbiota has been observed in patients with multiple sclerosis (pwMS) with respect to healthy controls (HC). Microorganism‐derived metabolites such as short‐chain fatty acids (SCFA) have been suggested to play a role in the disease.
Maria Inmaculada Dominguez‐Mozo, Daniel López‐Mecández, Luisa María Villar, Lucienne Costa‐Frossard, Noelia Villarrubia, Yolanda Aladro, Belén Pilo, Xavier Montalbán, Manuel Comabella, Ignacio Casanova‐Peño, Inés González‐Suárez, María Luisa Martínez‐Ginés, Jose Manuel García‐Domínguez, Estefanía García‐Calvo, Andrés Machuca‐Marcos, Jose Luis Luque‐Garcia, María Angel Garcia‐Martinez, Rafael Arroyo, Roberto Alvarez‐Lafuente   +18 more
wiley   +1 more source