Results 51 to 60 of about 5,972 (165)

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray   +16 more
wiley   +1 more source

Advancements in Mass Spectrometry‐Based Glycomics in Food and Nutritional Science

open access: yesMass Spectrometry Reviews, Volume 45, Issue 4, Page 829-850, July/August 2026.
ABSTRACT This review highlights advancements in mass spectrometry (MS)‐based glycomics in food and nutritional science. Carbohydrates, which are vital for human health, exhibit complex structures, making their analysis challenging. MS has become an indispensable tool for elucidating the structures of carbohydrates, including glycans, through soft ...
JaeHui Song   +3 more
wiley   +1 more source

Mass spectrometry proteomics for studying mitostasis

open access: yesProtein Science, Volume 35, Issue 7, July 2026.
Abstract Maintaining mitochondrial integrity and function is fundamental to cellular homeostasis. Cells rely on coordinated protein quality control (QC) systems—including intricate chaperone‐protease networks, the ubiquitin‐proteasome system, and cytosolic surveillance pathways—that together form a dynamic, cell‐wide mitostasis network governing the ...
Lakshita Sharma   +5 more
wiley   +1 more source

Magnesium as a conformational gatekeeper of KRAS: Structural dynamics and therapeutic implications

open access: yesProtein Science, Volume 35, Issue 7, July 2026.
Abstract Magnesium serves as an essential cofactor for small GTPases, yet its structural role in regulating KRAS conformational dynamics and nucleotide exchange remains poorly understood. Here, we combine hydrogen–deuterium exchange mass spectrometry (HDX‐MS), native mass spectrometry, and functional assays to elucidate how Mg2+ stabilizes the KRAS ...
Bindu Y. Srinivasu   +6 more
wiley   +1 more source

Myth or Merit? A Reassessment of the “Monks From Afar” Effect in Taiwan's Dual‐Track Talent Policy in Higher Education

open access: yesHigher Education Quarterly, Volume 80, Issue 3, July 2026.
ABSTRACT In response to global talent competition and the goal of building world‐class universities, Taiwan's government introduced talent policies to enhance research capacity and international visibility. This study employs a mixed‐methods design to analyse the distribution of four main awardee types in alignment with Taiwan's dual talent policies ...
Angela Yung Chi Hou   +5 more
wiley   +1 more source

Inhibition of jasmonic acid‐isoleucine conjugating enzyme JAR1 shifts the local and systemic leaf signals and metabolic profiles in Arabidopsis

open access: yesNew Phytologist, Volume 251, Issue 1, Page 424-437, July 2026.
Summary Jasmonates (JAs)‐mediated pathways are central signaling hubs in plant defense responses. However, the identification of mobile and nonmobile signals involved in downstream systemic signaling is still less studied. Here, we investigate the role of the jasmonic acid‐isoleucine (JA‐Ile) conjugating enzyme, JAR1, in shifting wound‐induced local ...
Ming Zeng, Axel Mithöfer
wiley   +1 more source

A CRITICAL REVISION OF THE SALENTO PENINSULA SEISMICITY: THE CASE OF THE FEBRUARY 20, 1743 EARTHQUAKE AND RELATED ENVIRONMENTAL EFFECTS.

open access: yes, 2014
The area of the Salento peninsula (Apulia, Southern Italy) is considered the stable foreland of the Southern Apennines chain (Cinque et al., 1993), although it has been hit by several low energy and a few high energy earthquakes over the last centuries.
Gaudiosi, G.   +4 more
core   +1 more source

Provenance legacies override species effects in shaping oak rhizosphere microbiomes and metabolomes

open access: yesNew Phytologist, Volume 251, Issue 1, Page 488-504, July 2026.
Graphical representation of experimental setup. Quercus spp. seeds were collected at two origins: upper Rhine basin (URB) and north German lowland (NGL). Summary As climate change drives more frequent drought‐heat extremes, selecting drought‐tolerant trees is crucial for future forest resilience. However, the role of tree–microbial associations remains
Sebastian Bibinger   +9 more
wiley   +1 more source

An N‐acetyltransferase‐MAPK fusion protein modulates developmental reprogramming in Physcomitrium patens

open access: yesNew Phytologist, Volume 251, Issue 1, Page 321-339, July 2026.
Summary We discovered a previously uncharacterized moss‐specific protein, Rosetta NATD‐MAPK 1 (RAK1) in Physcomitrium patens, which uniquely integrates MAP kinase (MAPK)‐dependent signaling with N‐acetyltransferase activity. Through phenotypical and biochemical analyses, we characterized RAK1 function in the regulation of the 2D‐to‐3D growth transition.
Cloe de Luxán‐Hernández   +17 more
wiley   +1 more source

Endophyte‐induced systemic spatial reprogramming of metabolism in Populus trichocarpa roots under drought

open access: yesNew Phytologist, Volume 251, Issue 1, Page 438-454, July 2026.
Summary Beneficial, facultative endophytes help plants thrive in challenging environments by altering their host's metabolism, but how these cellular scale metabolic changes propagate to the systems biology scale is unknown. In this work, we employed a high‐resolution chemical imaging approach to map metabolic changes at the Populus trichocarpa root ...
Jayde Aufrecht   +9 more
wiley   +1 more source

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