Results 91 to 100 of about 4,835,110 (353)

Role of photodynamic therapy in the treatment of esophageal cancer

Digestive Endoscopy, 2019
Photodynamic therapy (PDT), a treatment of choice for cancer, induces a photochemical reaction, thereby eradicating tumor cells. This is achieved through the administration of a photosensitizer drug, which is activated with a laser after localization to ...
Hao Wu, T. Minamide, T. Yano
semanticscholar   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Endoscopic screening for esophageal squamous cell carcinoma [PDF]

, 2013
Esophageal cancer (EC) is the eighth common cancer and the sixth most common cause of death from cancer worldwide. Esophageal squamous cell carcinoma (ESCC) remains the most common type of EC in the developing world and an important health problem in ...
Amiriani, T., Khoshnia, M., Merat, S., Nouroozi, A., Pourshams, A., Roshandel, G., Semnani, S.   +6 more
core  

Assessment of body composition and sarcopenia in patients with esophageal cancer: a systematic review and meta-analysis.

Diseases of the esophagus, 2018
There has recently been increased interest in the assessment of body composition in patients with esophageal cancer for the purpose of nutritional evaluation and prognostication.
P. Boshier, Rachel E. Heneghan, S. Markar, Vickie E. Baracos, Donald E. Low   +4 more
semanticscholar   +1 more source

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo. [PDF]

, 2015
BACKGROUND: Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency.
Alder, Hansjuerg, Chen, Hongping, Croce, Carlo M., Di Leva, Gianpiero, Fadda, Paolo, Farber, John L., Fong, Louise, Garofalo, Michela, Jiang, Yubao, Middleton, Justin, Naidu, Srivatsava, Selmi, Tommaso, Smalley, Karl J., Taccioli, Cristian, Tagliazucchi, Guidantonio Malagoli   +14 more
core   +1 more source

Surgical treatment combined with preoperative concentrated irradiation for esophageal cancer [PDF]

, 1967
K Nakayama, Hideo Orihata, Keizo Yamaguchi   +2 more
openalex   +1 more source

Esophageal Cancer: Esophageal Cancer Drug Therapy

Annals of Oncology, 2012
ABSTRACT For resectable esophageal cancer (stage II/II, non-T4), two courses of pre-operative chemotherapy with 5-fluorouracil (5-FU) plus cisplatin (CDDP) (FP) showed a significant survival benefit compared with post-operative chemotherapy with the same regimen in JCOG9907 trial (5-year survival rate; 60% versus 38%).
openaire   +2 more sources

From Tumor Immunology to Immunotherapy in Gastric and Esophageal Cancer

International Journal of Molecular Sciences, 2018
Esophageal and gastric cancers represent tumors with poor prognosis. Unfortunately, radiotherapy, chemotherapy, and targeted therapy have made only limited progress in recent years in improving the generally disappointing outcome.
D. Vrána, M. Matzenauer, Č. Neoral, R. Aujeský, R. Vrba, B. Melichar, N. Rušarová, M. Bartoušková, J. Jankowski   +8 more
semanticscholar   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source