Results 91 to 100 of about 785,637 (307)

RNA editing is induced by type I interferon in esophageal squamous cell carcinoma

open access: yesTumor Biology, 2017
In recent years, abnormal RNA editing has been shown to play an important role in the development of esophageal squamous cell carcinoma, as such abnormal editing is catalyzed by ADAR (adenosine deaminases acting on RNA). However, the regulatory mechanism
Jinyao Zhang   +5 more
doaj   +1 more source

Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus

open access: yes, 2013
AIM: To assess tumour regression grade (TRG) and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS: Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal ...
Kelly, Jamie   +10 more
core   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

open access: yesAdvanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang   +13 more
wiley   +1 more source

The significance of CD4+ and CD8+ T lymphocyte infiltration in esophageal squamous cell carcinoma

open access: yesIndian Journal of Pathology and Microbiology
Purpose: To investigate the relationship between the abundance of CD4+ and CD8+ T cells in the tumor microenvironment and the prognosis of patients with esophageal squamous cell carcinoma, and to analyze their correlation and explore its clinical value ...
Jiang Y. Zhao   +5 more
doaj   +1 more source

Cellular and Molecular Biology of Esophageal Cancer

open access: yes, 2015
Esophageal cancers comprise cancers of different histological types with diverse cellular and molecular bases. The major histological types of esophageal cancers are squamous cell carcinoma and adenocarcinoma.
Lam, AKY   +2 more
core   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

open access: yesAdvanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang   +14 more
wiley   +1 more source

Carrier cell-mediated cell lysis of squamous cell carcinoma by squamous cell carcinoma antigen 1 promoter-driven oncolytic adenovirus [PDF]

open access: yes, 2009
The squamous cell carcinoma antigen (SCCA) serves as a serological marker for squamous cell carcinomas. Molecular cloning of the SCCA genomic region has revealed the presence of two tandemly arrayed genes, SCCA1 and SCCA2.
Yoshiyuki Koyama   +7 more
core  

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

open access: yesAdvanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang   +11 more
wiley   +1 more source

Evaluation of the importance of gastroscopy and analysis of clinical characteristics in hypopharyngeal carcinoma comorbid with esophageal cancer

open access: yesZhongguo aizheng zazhi, 2020
Background and purpose: Esophageal cancer is common malignant tumor of digestive system. The prognosis of hypopharyngeal carcinoma, the most common type of squamous cell carcinoma of the head and neck, comorbid with esophageal cancer is poor.
唐曦平   +3 more
doaj  

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