Results 181 to 190 of about 204,995 (239)

Prognostic Value of an Early Response to Tolvaptan and Its Clinical Implications in Patients With Cirrhosis and Hepatic Edema: A Nationwide Multicenter Cohort Study

open access: yesHepatology Research, EarlyView.
In a nationwide multicenter cohort, an early response to tolvaptan (≥ 1.5‐kg weight loss within 7 days) was independently associated with improved long‐term survival in patients with cirrhosis and hepatic edema. Early initiation before renal impairment or hyponatremia may optimize treatment response and prognosis. ABSTRACT Aim Hepatic edema indicates a
Kaori Koyano   +22 more
wiley   +1 more source

Precision medicine in cutaneous melanoma—A comprehensive review

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Precision medicine tailors treatment to each patient, beginning with detailed diagnostics. In melanoma, it has advanced considerably: Some methods are in practice and guidelines, while others are commercially available but not routine. This review highlights current and emerging approaches, including molecular profiling, imaging, biomarkers and AI ...
Markus Reitmajer, Lukas Flatz
wiley   +1 more source

Clinicopathological Analysis and Survival Outcomes of Radiation‐Induced Oral Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis

open access: yesJournal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Radiotherapy‐induced malignancies are well‐documented, but the clinicopathological profile and prognostic factors of radiation‐induced oral squamous cell carcinoma (R‐OSCC) remain unclear. Methods The present review was conducted in accordance with the PRISMA guidelines and has been registered in the PROSPERO (registration number ...
Anne Evelyn Oliveira Moura   +9 more
wiley   +1 more source

Defining Pharyngeal and Upper Esophageal Sphincter Disorders on High‐Resolution Manometry‐Impedance: The Leuven Consensus

open access: yesNeurogastroenterology &Motility, EarlyView.
The Leuven Consensus provides a classification scheme for the diagnosis of pharyngeal and upper esophageal sphincter (UES) motor disorders using metrics derived from pharyngeal high‐resolution manometry‐impedance (P‐HRM‐I). These recommendations complement routine instrumental investigations and provide a standardized process, criteria, and ...
Taher I. Omari   +25 more
wiley   +1 more source

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

open access: yesAnnals of the New York Academy of Sciences, EarlyView.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge   +5 more
wiley   +1 more source

The prognostic significance of FMR1 expression and its immunomodulatory implications in esophageal carcinoma. [PDF]

open access: yesAm J Clin Exp Immunol
Tang Q   +8 more
europepmc   +1 more source

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