Results 101 to 110 of about 9,668,529 (318)

Signatures within the esophageal microbiome are associated with host genetics, age, and disease

Microbiome, 2018
The esophageal microbiome has been proposed to be involved in a range of diseases including the esophageal adenocarcinoma cascade; however, little is currently known about its function and relationship to the host. Here, the esophageal microbiomes of 106
Nandan P. Deshpande, S. Riordan, N. Castaño-Rodríguez, M. Wilkins, N. Kaakoush   +4 more
semanticscholar   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Emerging Issues in Esophageal Motility Diseases

The Korean Journal of Gastroenterology, 2019
With the advances in technology and medical knowledge, new diseases are being identified and investigated. Esophageal motility disorders have been re-defined using high-resolution manometry and their pathogenesis are being better understood.
Ga Hee Kim, Kee Wook Jung
doaj   +1 more source

Transcribed ultraconserved noncoding RNAs (T-UCR) are involved in Barrett's esophagus carcinogenesis. [PDF]

, 2014
Barretts esophagus (BE) involves a metaplastic replacement of native esophageal squamous epithelium (Sq) by columnar-intestinalized mucosa, and it is the main risk factor for Barrett-related adenocarcinoma (BAc).
Baffa, R, Bornschein, J, Braconi, C, Croce, CM, D'Angelo, E, Dall'Olmo, L, Fassan, M, Galasso, M, Gasparini, P, Nuovo, GJ, Pizzi, M, Realdon, S, Rugge, M, Souza, RF, Valeri, N, Vicentini, C, Volinia, S, Zaninotto, G   +17 more
core   +4 more sources

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li, Jie Yuan, Min Gao, Jibin Liu, Qinqin Wang, Yaqi Zhang, Mingtao Cao, Xiaolin Hu, Hui Yang, Jun Li, Chen Li, Xiaoguang Li, Hui Wang   +12 more
wiley   +1 more source

Miotomía de Heller por vía laparoscópica: un procedimiento seguro

Revista Colombiana de Cirugía
Introducción. La miotomía de Heller como tratamiento quirúrgico de elección para la acalasia, ofrece de buenos a excelentes resultados a corto y largo plazo, pero, incluso en manos de cirujanos experimentados, pueden presentarse complicaciones. Objetivos.
Bernardo A. Borráez, Marco G. Patti
doaj  

KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF.

PLoS ONE, 2019
Understanding the regulatory mechanisms within esophageal epithelia is essential to gain insight into the pathogenesis of esophageal diseases, which are among the leading causes of morbidity and mortality throughout the world.
Khvaramze Shaverdashvili, Jennie Padlo, Daniel Weinblatt, Yang Jia, Wenpeng Jiang, Divya Rao, Dorottya Laczkó, Kelly A Whelan, John P Lynch, Amanda B Muir, Jonathan P Katz   +10 more
doaj   +1 more source

Esophageal reconstruction results in surgery of pediatric patients with complex esophageal pathology in two high level hospitals of Medellín, Colombia, 2006-2016

Iatreia, 2017
Introduction: complex esophagus represents a final condition that occurs secondary to diseases that require multiple procedures or esophageal replacement surgery, either because it is the only treatment or because others interventions have failed.
Herrera-Toro, Natalia, Arango-Rave, María Elena, Peña-Aguirre, Laura, Silvera-Valera, Michelle Carolina   +3 more
doaj   +1 more source

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

Advanced Science, EarlyView.
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo, Ting Yang, Jiaxin Cao, Qun Chen, Zhenhai Lu, Feiteng Lu, Chaozhuo Lin, Zengfei Xia, Yuanzhong Yang, Peng Li, Wenjuan Ma, Min Luo, Rongxin Zhang   +12 more
wiley   +1 more source

Temporal variations of dietary habits in a high-risk area for upper gastrointestinal cancers: A population-based study from Northern Iran [PDF]

, 2015
Background: Nutrition transition is a global health problem, especially in developing countries. It is known as an important factor for development of different types of health conditions including cancers.
Aboomardani, M., Roshandel, G., Salamat, F., Semnani, S.   +3 more
core   +1 more source