Results 251 to 260 of about 337,805 (303)

Advancing gambogic acid for translational oncology: Redox–proteostasis collapse, multidrug resistance reversal, nanodelivery and biomarker‐guided development

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Gambogic acid exerts anticancer effects through reactive oxygen species‐mediated apoptosis, suppression of nuclear factor kappa B and phosphatidylinositol‐3‐kinase–protein kinase B signalling, multidrug resistance modulation and tumour microenvironment effects.
Uttam Singh Baghel, Kajal Gurow, Geetanjali Mehara, Priyanka Kriplani, Neelam M. Patel, Abhay Sharma, Deeksha Singh, Atamjit Singh, Suchi Dave, Bhawani Singh, Lashyn N. Kiyekbayeva, William N. Setzer, Javad Sharifi‐Rad, Cheryl Grace Pratiwi Rumahorbo, Daniela Calina   +14 more
wiley   +1 more source

Immunotherapy-based adjuvant treatment after neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma according to pathological response. [PDF]

Front Immunol
Wang C, Geng X, Cheng X, Ren R, Jin L, Sheng Z, Li S, Zang M, Zhang Y.   +8 more
europepmc   +1 more source

Different Pattern of Treatment Failure After Chemoradiation Between p16+ and p16− Patients Affected by Oropharyngeal Carcinoma

Head &Neck, Volume 48, Issue 8, Page 2048-2056, August 2026.
ABSTRACT Background Oropharyngeal cancer (OPC) exhibits distinct clinical behaviors according to HPV/p16 status and smoking exposure. While HPV‐positive OPC generally shows superior survival, differences in recurrence patterns remain unclear. Methods A retrospective multicenter analysis of 674 AJCC VII edition Stage III–IVa/b OPC patients treated with ...
Riccardo Gili, Paolo Bossi, Luca Lalli, Lisa Francesca Linda Licitra, Marta Maddalo, Almalina Bacigalupo, Liliana Belgioia, Jon Cacicedo, Nadia Facchinetti, Almudena Garcia Castano, Marc Oliva, Pierluigi Bonomo, Giuseppe Sanguineti, Pierfrancesco Franco, Athanassios Argiris, Amanda Psyrri, Ester Orlandi   +16 more
wiley   +1 more source

Silencing of small nuclear ribonucleoprotein polypeptide B inhibits the progression of esophageal squamous cell carcinoma. [PDF]

Oncol Lett
Guo H, Zuo J, Hu G, Tang Y, Lu L, Luo Z, Chen X, Wang X, Wang X.   +8 more
europepmc   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

Identification and validation of prognostic genes related to mitochondrial dynamics and mitochondrial autophagy in esophageal squamous cell carcinoma. [PDF]

J Thorac Dis
Lin H, Zhuang FN, Chen WJ, Wei WW, Gao PQ, Wang PY, Wang F, Shi S.   +7 more
europepmc   +1 more source

Preoperative Circulating Tumor DNA Detection and Risk Stratification in Esophageal Squamous Cell Carcinoma.

JAMA Surg
Hong TH, Jeong JG, Park SY, Park BJ, Kyung D, Kim HP, Zhu J, Yang YH, Kim HE, Lee CY, Lee JG, Jeon YJ, Lee J, Cho JH, Choi YS, Shim YM, Lee SH, Kim DJ, Kim HK.   +18 more
europepmc   +1 more source

A combined immune-nutritional score as a prognostic indicator in neoadjuvant-treated esophageal squamous cell carcinoma. [PDF]

Front Immunol
Xie Q, Zhan J, Ye X, Huang C, Chen C, Zheng B, Xu G, Yang Z, Zhu Y.   +8 more
europepmc   +1 more source

Response to nivolumab as an immune checkpoint inhibitor rechallenge for esophageal squamous cell carcinoma with <i>PD-L1</i> amplification: a case report. [PDF]

Ther Adv Med Oncol
Kodama H, Masuishi T, Ishizuka Y, Sakakida T, Honda K, Narita Y, Taniguchi H, Kadowaki S, Ando M, Hosoda W, Muro K.   +10 more
europepmc   +1 more source

Peroxiredoxin 4 suppresses ferroptosis in esophageal squamous cell carcinoma by activating the phosphoinositide 3-kinase  signaling pathway. [PDF]

Biomed Rep
Li K, Xu S, Liu H, Fan T, Li Y, Ren R, Xu Y, Li S, Liu Y.   +8 more
europepmc   +1 more source