Results 61 to 70 of about 21,359 (272)

PD-1 inhibition in patient derived tissue cultures of human gastric and gastroesophageal adenocarcinoma

OncoImmunology, 2021
Emerging immunotherapies quest for better patient stratification in cancer treatment decisions. Moderate response rates of PD-1 inhibition in gastric and esophagogastric junction cancers urge for meaningful human model systems that allow for ...
Marlon Hußtegge, Ngoc Anh Hoang, Jakob Rebstock, Astrid Monecke, Ines Gockel, Arved Weimann, Guido Schumacher, Ingo Bechmann, Florian Lordick, Sonja Kallendrusch, Justus Körfer   +10 more
doaj   +1 more source

Risk of Malignant Progression in Barrett’s Esophagus Patients: Results from a Large Population-Based Study [PDF]

, 2011
BACKGROUND: Barrett’s esophagus (BE) is a premalignant lesion that predisposes to esophageal adenocarcinoma. However, the reported incidence of esophageal adenocarcinoma in patients with BE varies widely.
A. T. Gavin, Avidan, B. T. Johnston, Bani-Hani, Chandrasoma, Chandrasoma, Conio, Cook, D. T. McManus, de Jonge, de Jonge, Dulai, Eloubeidi, F. Yousef, Gatenby, Gatenby, Gopal, H. G. Coleman, Hage, L. J. Murray, Lagergren, Macdonald, Marsman, McGarrity, Murray, Nilsson, Oberg, Provenzale, Riddell, S. Bhat, Sharma, Skacel, Somerville, Steevens, Streitz, van Blankenstein, Wang, Weston, Wright   +38 more
core   +1 more source

Analysis of N6-Methyladenosine Methylome in Adenocarcinoma of Esophagogastric Junction

Frontiers in Genetics, 2022
Background: From previous studies, we found that there are more than 100 types of RNA modifications in RNA molecules. m6A methylation is the most common.
Jia-Bin Huang, Bin-Bin Hu, Rong He, Lian He, Chen Zou, Chang-Feng Man, Yu Fan   +6 more
doaj   +1 more source

Impaired Esophageal Motility and Clearance Post-Lung Transplant: Risk For Chronic Allograft Failure [PDF]

, 2017
Objectives: Gastroesophageal reflux is common in patients post-lung transplantation (LTx) and thus considered a risk factor for aspiration and consequently allograft rejection and the development of chronic allograft failure. However, evidence supporting
Almansa, Atkins, Atkins, Blondeau, Cantu, Davis, Davis, Davis, DOvidio, DOvidio, Fisichella, Fisichella, Frazzoni, Frazzoni, Griffin, Hadjiliadis, Johnson, Kahrilas, Mendez, Meyer, Pegna, Ribolsi, Robertson, Roman, Sato, Shay, Stovold, Tutuian, Verleden, Ward, Young   +30 more
core   +1 more source

Phase I/II Prospective Study on Endoscopic Ultrasound‐Guided Hepaticogastrostomy as Primary Drainage for Unresectable Malignant Hilar Biliary Obstruction

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objectives Various drainage methods have been used for unresectable malignant hilar biliary obstruction (MHBO). However, controlling cholangitis and obstructive jaundice is still challenging. We performed a phase I/II study of endoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS) as primary drainage for MHBO.
Tomoki Ogata, Kazuo Hara, Nozomi Okuno, Shin Haba, Takamichi Kuwahara, Shimpei Matsumoto, Hiroki Koda, Keigo Oshiro   +7 more
wiley   +1 more source

Macroscopic and histomorphometric analysis of the esophagogastric junction region of horses used for traction [PDF]

Biotemas, 2011
The esophagogastric junction was evaluated macroscopically and histologically, seeking to identify adaptive changes in a sample of six adult horses, being four males and two females, used for traction.
Eduardo Maurício Mendes de Lima, Marcelo Ismar Silva Santana, Márcio Botelho de Castro, Hildebrando Gomes Benedicto, Pedro Primo Bombonato, Laura Reis e Silva   +5 more
doaj  

Fate of the esophagogastric anastomosis [PDF]

, 2005
ObjectiveThe study objective was to evaluate histopathology of the esophagogastric anastomosis after esophagectomy, determine time trends of histologic changes, and identify factors influencing those findings.MethodsA total of 231 patients underwent 468 ...
Rice, Thomas W., Goldblum, John R., Rybicki, Lisa A., Rajeswaran, Jeevanantham, Murthy, Sudish C., Mason, David P., Blackstone, Eugene H.   +6 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, Volume 20, Issue 5, Page 1323-1346, May 2026.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Paget’s disease derived in situ from reserve cell hyperplasia, squamous metaplasia, and squamous cell carcinoma of the esophagogastric junction: a case report

Surgical Case Reports, 2018
Background Extramammary Paget’s disease (EMPD) of the esophagus is a rare tumor, with most cases originating from invasive adenocarcinoma of the esophagus.
Akihiko Sano, Shinji Sakurai, Chika Komine, Yuichi Tabe, Kana Saito, Takaharu Fukasawa, Shinsuke Kiriyama, Hideki Yamamoto, Masachika Tani, Hiroshi Naitoh, Ken Shirabe, Hiroyuki Kuwano   +11 more
doaj   +1 more source

Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients. [PDF]

, 2017
BackgroundTopoisomerase I (TOPO1) and topoisomerase IIα (TOP2A) are specific targets of multiple chemotherapy drugs. Increased expression of TOPO1 protein and amplification of the TOP2A gene have been associated with treatment response in colorectal and ...
Arguello, David, Gatalica, Zoran, Heestand, Gregory M, Kurzrock, Razelle, Schwaederle, Maria   +4 more
core   +1 more source