Results 151 to 160 of about 446,222 (404)

An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission [PDF]

Jiarui Ding, John J. Garber, Amiko M. Uchida, Ariel Lefkovith, Grace T. Carter, Praveen Vimalathas, Lauren Canha, Michael Dougan, Kyle Staller, Joseph C. Yarze, Toni Delorey, Orit Rozenblatt–Rosen, Orr Ashenberg, Daniel B. Graham, Jacques Deguine, Aviv Regev, Ramnik J. Xavier   +16 more
openalex   +1 more source

NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer

Advanced Science, EarlyView.
This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang, Qingling Zhang, Yuhan Zhang, Xinlu Yu, Bo Jia, Yulong Dong, Yalong Wu, Kelong Fan, Xinquan Gu, Lei Ji, Wei Jiang, Bin Liu   +11 more
wiley   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Independent test of a model to predict severe acute esophagitis [PDF]

, 2017
Bradley, Jeffrey D, Deasy, Joseph O, Huang, Ellen X, Molotievschi, Alerson, Oh, Jung Hun, Robinson, Clifford G   +5 more
core   +2 more sources

Chaotic peak propagation in patients with Jackhammer esophagus

, 2019
Yinglian Xiao, Dustin A. Carlson, Zhiyue Lin, John E. Pandolfino   +3 more
openalex   +2 more sources

T Cell Exhaustion and Dendritic Cell‐Mediated Tertiary Lymphoid Structures (TLSs) Modulation Affect Response to Neoadjuvant Chemoradiotherapy in Microsatellite Stable Rectal Cancer

Advanced Science, EarlyView.
Using multi‐omics analysis, this study demonstrates that immune characteristics of the tumor microenvironment, rather than mutational profiles, are more strongly correlated with treatment response. Specifically, early exhausted T cells and tertiary lymphoid structures regulation by LAMP3⁺ dendritic cells emerge as key predictors of favorable outcomes ...
Miao Wang, Jiejun Shi, Kai Xu, Leyi Yu, Xiaomao Yin, Jiexuan Wang, Lin Zhu, Xin Yang, Jingjing Qian, Wenqiang Wang, Liangchen Zhu, Xuan Dai, Zekun Zhao, Jinran Wu, Dongsheng Li, Zhiqian Hu, Qi Huang, Xinxing Li   +17 more
wiley   +1 more source

Lysyl Oxidase Mediates Proliferation and Differentiation in the Esophageal Epithelium

Biomolecules
In homeostatic conditions, the basal progenitor cells of the esophagus differentiate into a stratified squamous epithelium. However, in the setting of acid exposure or inflammation, there is a marked failure of basal cell differentiation, leading to ...
Kanak V. Kennedy, Joshua X. Wang, Emily McMillan, Yusen Zhou, Ryugo Teranishi, Ann Semeao, Leena Mirchandani, Chizoba N. Umeweni, Diya Dhakal, Alyssa Baccarella, Satoshi Ishikawa, Masaru Sasaki, Takefumi Itami, Adele C. Harman, Leonel Joannas, Tatiana A. Karakasheva, Hiroshi Nakagawa, Amanda B. Muir   +17 more
doaj   +1 more source

Surgical approaches to adenocarcinoma of the gastroesophageal junction: the Siewert II conundrum. [PDF]

, 2017
BACKGROUND: The Siewert classification system for gastroesophageal junction adenocarcinoma has provided morphological and topographical information to help guide surgical decision-making.
Berger, Adam C., Brown, Andrew M., Giugliano, Danica N., Palazzo, Francesco, Pucci, Michael J.   +4 more
core   +1 more source

Real‐Time In Vivo Monitoring of Anastomotic Intestinal Ischemia Using Implantable Resorbable Organic Sensors

Advanced Science, EarlyView.
Resorbable impedance sensors are successfully implanted into porcine small intestinal anastomoses. Impedance was recorded for 2 hours prior, and 2 hours following ischemia induction, and a significant drop in tissue impedance was observed. Abstract Anastomotic failure remains one of the most severe complications in gastrointestinal surgery.
Dennis Wahl, Finn Jaekel, Julia Henne, Richard Kantelberg, Daniel C. Freund, Eberhard Grambow, Brigitte Vollmar, Amelie R. Zitzmann, Hans Kleemann, Jochen Hampe, Sebastian Hinz, Clemens Schafmayer, Karl Leo   +12 more
wiley   +1 more source

Cancer of the Esophagus and Esophagogastric Junction: An Eighth Edition Staging Primer

Journal of Thoracic Oncology, 2017
T. Rice, Hemant Ishwaran, M. Ferguson, E. Blackstone, P. Goldstraw   +4 more
semanticscholar   +1 more source