Results 141 to 150 of about 205,049 (282)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Comment on the article: inflammatory mediators' essence in apical periodontitis [Letter to the editor]. [PDF]

Eur Oral Res
Asagry S.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

From Professionalism to Professional Identity: The Emerging Core of Modern Medical Education. [PDF]

Pak J Med Sci
Zaidi SH, Hadi BA.
europepmc   +1 more source

THE ESSENCE AND SPECIFIC FEATURES OF INTERACTION OF PUBLIC ADMINISTRATIVE BODIES WITH DIFFERENT AREAS OF LAW

, 2021
Yu. Yu. Paida
openalex   +1 more source

Essence

The Educational Forum, 1969
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Interpretable Artificial Intelligence Decodes the Chemical Structural Essence of Twisted Intramolecular Charge Transfer and Planar Intramolecular Charge Transfer Fluorophores. [PDF]

Research (Wash D C)
Huang S, Huang W, Fang Y, Zhu Y, Huang J, Chen F, Dong J, Zeng W.   +7 more
europepmc   +1 more source

Protection of ownership right in the court: the essence and particularities

, 2019
В.В. Вапнярчук, Iryna I. Puchkovska, Oleksii V. Tavolzhanskyi, Roman Tashian   +3 more
openalex   +1 more source

The essence of the emergence and realization of the economic interests of business entities [PDF]

Irina Vladimirovna Grigoreva, Liliia Matveevna Parfenchuk   +1 more
openalex   +1 more source