Results 101 to 110 of about 4,634,175 (249)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Assessment of estrogenic activity in some common essential oil constituents [PDF]

, 2002
M-J R Howes, P.J. Houghton, David J. Barlow, Victoria Pocock, S. R. Milligan   +4 more
openalex   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

An essential role for PNLDC1 in piRNA 3′ end trimming and male fertility in mice [PDF]

, 2017
Yue Zhang, Rui Guo, Yiqiang Cui, Zhi-Ping Zhu, Yingwen Zhang, Hao Wu, Bo Zheng, Qiuling Yue, Shun Bai, Wentao Zeng, Xuejiang Guo, Zuomin Zhou, Bin Shen, Ke Zheng, Mingxi Liu, Lan Ye, Jiahao Sha   +16 more
openalex   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Governance for public health across health and allied sectors: a scoping review

BMJ Public Health
Objectives This study elucidates the status of public health governance, defines the concept and synthesises the evidence to guide stakeholders in enhancing governance for the delivery of essential public health functions (EPHFs).Design A scoping review ...
Yu Zhang, Sohel Saikat, Neil Squires, Gerard Schmets, Duncan Selbie, Anne-Catherine Viso, Redda Seifeldin, Maryjane Nweje, Sabrina Shivji   +8 more
doaj   +1 more source

Introduction: Linkage, Engagement, and Retention in HIV Care: Essential for Optimal Individual- and Community-Level Outcomes in the Era of Highly Active Antiretroviral Therapy [PDF]

, 2010
Kenneth H. Mayer
openalex   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Essential role of β-adrenergic receptor kinase 1 in cardiac development and function

, 1996
Mohamed Jaber, Walter J. Koch, Howard A. Rockman, Bradley R. Smith, Richard A. Bond, Kathleen K. Sulik, John Ross, Robert J. Lefkowitz, Marc G. Caron, Bruno Giros   +9 more
openalex   +2 more sources