Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Availability of Analgesic and Anti-Inflammatory Medicines in Primary Health Care
Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2022 Objective: To describe and analyze the availability and factors related to the presence of analgesics and non-steroidal anti-inflammatory drugs in the Brazilian public primary healthcare system.
Jacqueline Silva Santos +3 more
doaj
Journal of Lumbini Medical College, 2019 Introduction: Drug utilization research is an important tool to facilitate rational use of drugs. In low income countries irrational use of drugs is a common problem like overuse of drugs and inappropriate use of antibiotics, leading to poor treatment ...
Naresh Karki +3 more
doaj +1 more source
The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery [PDF]
, 2007 Lori Buetow +3 more
openalex +1 more source
Efecto del aceite esencial de Minthostachys verticillata sobre la respuesta inmune de pacientes alérgicos a ácaros del polvo [PDF]
, 2009 El aceite esencial de hojas de M. verticillata fue obtenido por destilación en corriente de vapor y analizado por cromatografía gaseosa. Células mononucleares de sangre periférica de pacientes alérgicos, fueron estimuladas con aceite esencial.
Andrada, Melisa +6 more
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Conservation of gene essentiality in Apicomplexa and its application for prioritization of anti-malarial drug targets [PDF]
, 2017 Gajinder Pal Singh
openalex +1 more source
Prospects and Challenges of Medicinal Plants Conservation and\ud Traditional Medicine in Tanzania [PDF]
, 2013 A qualitative study was carried to assess prospects and challenges of medicinal plants conservation and\ud traditional medicine in Tanzania. The study shows that TRM and medicinal have great prospects in healthcare\ud delivery worldwide.
Kayombo, Edmund J +2 more
core
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source