Results 131 to 140 of about 349,688 (259)

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Impact of dietary essential fatty acids on phospholipid composition and mitochondrial function in aged mares. [PDF]

Sci Rep
Fresa K, Catandi GD, Gonzalez-Castro R, Omar A, Whitcomb LA, Cheng MH, Chen TW, Carnevale EM, Chicco AJ.   +8 more
europepmc   +1 more source

Elevated temperature and browning increase dietary methylmercury, but decrease essential fatty acids at the base of lake food webs. [PDF]

Sci Rep, 2021
Wu P, Kainz MJ, Valdés F, Zheng S, Winter K, Wang R, Branfireun B, Chen CY, Bishop K.   +8 more
europepmc   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

Association between enteral essential fatty acids and plasma phospholipid essential fatty acids related immune response in critically ill adults with COVID-19: A prospective cohort study. [PDF]

JPEN J Parenter Enteral Nutr
Mazurak VC, Rivas-Serna IM, Parsons SR, Monirujjaman M, Maybank KE, Rewa OG, Cave AJ, Richard C, Clandinin MT.   +8 more
europepmc   +1 more source

Engineering Nanoplatforms for Alzheimer's Disease Detection via Biomolecular Corona Proteomic and Lipidomic Profiling

Advanced Healthcare Materials, EarlyView.
Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco, Roberto Baretta, Andrea Di Fonzo, Andrea Armirotti, Stefano Cinti, Mara Mirasoli, Marco Frasconi, Claudia Corbo   +7 more
wiley   +1 more source

Expression of free fatty acid receptors in the liver of periparturient dairy cows supplemented with essential fatty acids and conjugated linoleic acid. [PDF]

JDS Commun
Michelotti TC, Imbert A, Veshkini A, Durand G, Hammon HM, Bonnet M.   +5 more
europepmc   +1 more source

The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia. [PDF]

Biomedicines, 2020
Rog J, Błażewicz A, Juchnowicz D, Ludwiczuk A, Stelmach E, Kozioł M, Karakula M, Niziński P, Karakula-Juchnowicz H.   +8 more
europepmc   +1 more source

A Modular Liver–Microbial Microfluidic Platform to Evaluate Therapeutic and Adverse Effects of Microbial Metabolites

Advanced Healthcare Materials, EarlyView.
This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan, In Young Hwang, Nanthini Jayabalan, Hui Ling Lee, Louis Jun Ye Ong, Chwee Teck Lim, Matthew Wook Chang, Yi‐Chin Toh   +7 more
wiley   +1 more source

Essential fatty acids and Barratt impulsivity in gambling disorder. [PDF]

BMC Psychiatry, 2020
Sanchez-Paez P, Perez-Templado J, Saiz-Ruiz J, Pastor O, Ibañez A.   +4 more
europepmc   +1 more source