Results 131 to 140 of about 4,637,538 (347)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Growth Spaces on Circular Domains Taking Values in a Banach Lattice, Embeddings and Composition Operators

open access: yesMathematics
We introduce the space of holomorphic growth spaces with values in a Banach lattice. We provide norm and essential norm estimates of the embedding operator, and we completely characterize the bounded and compact embeddings of the growth spaces using ...
Nihat Gökhan Göğüş
doaj   +1 more source

THE STUDY OF BIOLOGICAL VALUE OF QUINOA SEEDS (CHENOPODIUM QUINOA WILLD.) TO CREATE SPECIALIZED FOOD PRODUCTS [PDF]

open access: yesТехника и технология пищевых производств, 2016
Nowadays, an important part of the world food problem is a shortage of protein in the diet. This is a complicated problem, the significance of which is related to the special role of protein in a human life. The negative dynamics of protein value changes
Shchekoldina T.V.   +2 more
doaj  

Composition Operators on Cesàro Function Spaces

open access: yesJournal of Function Spaces, 2014
The compact, invertible, Fredholm, and closed range composition operators are characterized. We also make an effort to compute the essential norm of composition operators on the Cesàro function spaces.
Kuldip Raj, Suruchi Pandoh, Seema Jamwal
doaj   +1 more source

The essential norm of an operator and its adjoint [PDF]

open access: yesTransactions of the American Mathematical Society, 1980
Allen L. Shields   +2 more
openaire   +1 more source

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